Category: 55121-99-8

55121-99-8, (4-Aminophenyl)(4-methylpiperazin-1-yl)methanone is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

55121-99-8, 4-(4-(4-methyl piperazine-1-carbonyl) phenyl) amino-6- […] (intermediate 1-c) weighing 4-chloro-6- […] (1-a, 0 . 16g, 0.58mmol) in isopropanol (5 ml), add 4-(4-methyl piperazine-1-carbonyl) aniline (0.14g, 0 . 64mmol), to reflux temperature under nitrogen for 5h, cooling to room temperature, filter, the white solid obtained 1-c (0.18g, 73%).

As the paragraph descriping shows that 55121-99-8 is playing an increasingly important role.

Reference£º
Patent; Xi’an Jiaotong University; Xin, Minghang; Zhang, Sanqi; Zhang, Hao; Xie, Xiaoxiao; Hei, Yuanyuan; Zuo, Saijie; Mao, Shuai; (40 pag.)CN105237484; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

55121-99-8, (4-Aminophenyl)(4-methylpiperazin-1-yl)methanone is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

55121-99-8, Compound 6 A flask was charged with intermiediate 1 (150mg, 0.5 mmol), l-(4-aminobenzoyl)-4-m ethyl piperazine (109 mg, 0.5 mmol), TFA (50uL), isopropanol (3mL). The reaction was heated to 100C for 4h. The reaction mixture was basified with a saturated aqueous sodium bicarbonate solution and then was extracted with DCM/ (10 mlx3). The combined organic was washed by brine, dried over sodium sulfate and concentrated. The crude product was purified with flash chromatography (0-10% MeOH-in DCM) to afford the desired product as light yellow solids (160 mg, 66% yield). 1H MR (400 MHz, DMSO-d6) delta 11.36 (br, 1H), 10.17 (br, 1H), 8.34 (s, 1H), 7.63 (d, J = 8.8 Hz, 2H), 7.39 (d, J = 8.8 Hz, 2H), 7.13 (d, J = 8.4 Etazeta, IotaEta), 6.96 (t, J = 7.6 Hz, 1H), 6.24 (s, 1H), 3.80-3.40 (br, 4H), 2.40 (s, 3H), 2.36-2.24 (br, 4H), 2.19 ( s, 3H); ESI-MS: calcd for (C26H24FN702) 485, found 486 (MH+).

55121-99-8 (4-Aminophenyl)(4-methylpiperazin-1-yl)methanone 231408, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; NANTBIOSCIENCE, INC.; TAO, Chunlin; POLAT,, Tulay; WEINGARTEN, Paul; NALLAN, Laxman; ARP, Forrest; WANG, Qinwei; HO, David; (129 pag.)WO2016/138527; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

55121-99-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55121-99-8,(4-Aminophenyl)(4-methylpiperazin-1-yl)methanone,as a common compound, the synthetic route is as follows.

(11) methyl 3-(Z)-[1-{4-[(4-methyl-piperazin-1-yl)-carbonyl]-phenylamino}-1-phenyl-methylidene]-2-indolinone-6-carboxylate Prepared from 1-acetyl-3-(1-ethoxy-1-phenylmethylene)-6-methoxycarbonyl-2-indolinone and 4-(4-methyl-piperazin-1-yl-carbonyl)-aniline. Yield: 0.1 g (23% of theoretical), Melting point: 196-197 C.

As the paragraph descriping shows that 55121-99-8 is playing an increasingly important role.

Reference£º
Patent; Roth, Gerald Juergen; Heckel, Armin; Lehmann-Lintz, Thorsten; Kley, Joerg; Hilberg, Frank; Van Meel, Jacobus; US2003/92756; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

55121-99-8, (4-Aminophenyl)(4-methylpiperazin-1-yl)methanone is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

55121-99-8, A solution of 4-(4-methylpiperazine-1-carbonyl)aniline (1.03g, 4.56 mmol) in THF (50 mL) was cooled to 0C and LiAlH41 M in THF (14 mL, 14 mmol) was added dropwise. The mixture was let to warm to room temperature, and then refluxed for 3 h. After cooling to 0C Na2SO4.10H2O was added and the solution was filtered off. The solution was concentrated and purified by silica flash chromatography with 0 to 5% MeOH in DCM to give 4-[(4- methylpiperazin-1-yl)methyl]aniline (500 mg, 53% yield). MS found for C12H19N3 as (M+H)+ 206.3.

The synthetic route of 55121-99-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PHARMACYCLICS LLC.; ATALLAH, Gordana, Babic; CHEN, Wei; JIA, Zhaozhong, J.; POZZAN, Alfonso; RAVEGLIA, Lucal, Francesco; ZANALETTI, Riccardo; (815 pag.)WO2016/196776; (2016); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

55121-99-8, (4-Aminophenyl)(4-methylpiperazin-1-yl)methanone is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

55121-99-8, Example No. 131Preparation of 5- (3-methoxyphenyl) -N- (4- ( (4-methylpiperazin-l- yl) methyl) phenyl) -IH-pyrazolo [4 , 3-d] pyrimidin-7-amine7-chloro-2- (4-methoxybenzyl) -5- (3-methoxyphenyl) -2H- pyrazolo [4 , 3 -d] pyrimidine (0.16 mmol) and 4 -Amino-phenyl) – (4 – methyl-piperazin-l-yl) -methanone (0.3 mmol 2 eq. , ) were suspended in MeOH (dry, 3mL) in a microwave vial (2-5mL) , HCl in dioxane (4M, 3 drops) was added. The reaction mixture was irradiated in a microwave reactor for 5 min at 140C. The reaction mixture was evaporated and used without further purification. The residue was dissolved in TFA (3mL) . The reaction mixture was irradiated in a microwave reactor for 5 min at 140 C. The reaction mixture was concentrated and dissolved in THF (dry) LiAlH4 powder was added (excess, 2 by 2 eq) until completion of reaction is observed (by LCMS) . The reaction was quenched with water (lmL per gram LiAlH4) , then NaOH (ca. 15% aq. , lmL per g LiAlH ) , water (3mL per gram LiAlH4) . The mixture was filtered, washed with THF, MeOH, MeCN (ca. 10ML each) . The reaction mixture was concentrated and purified by semi-preparative HPLC-MS and freeze dried from water/t-BuOH 4/1. exact mass: 429.27 g/molHPLC-MS: analytical method Art: 2.239 min – found mass: 430 (m/z+H)

The synthetic route of 55121-99-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ORIGENIS GMBH; ALMSTETTER, Michael; THORMANN, Michael; TREML, Andreas; TRAUBE, Nadine; WO2012/143144; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55121-99-8,(4-Aminophenyl)(4-methylpiperazin-1-yl)methanone,as a common compound, the synthetic route is as follows.

General procedure: An aqueous solution of sodium bicarbonate (0.57g, 6.78mmol) (20mL) was stirred at r.t. for 10min, and then compound 5a (0.50g, 2.26mmol) in dichloromethane (10mL) was added under ice-cooling. Thiophosgene (0.39g, 3.39mmol) in dichloromethane solution (5mL) was added dropwise for 0.5h. Reaction was stirred under ice-cooling for 6h. The aqueous phase was extracted with dichloromethane (20mL¡Á3). The combined organic phase was washed twice with saturated brine (20mL¡Á2) and dried over anhydrous MgSO4. After filtration, the solvent of filtrate was removed in vacuo, and the residue was purified by silica gel column chromatography (DCM : MeOH=100 : 1) to afford compound 6a as a pale-yellow solid; Yield: 63%, 55121-99-8

The synthetic route of 55121-99-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Heng, Hao; Wang, Zhijie; Li, Hongmei; Huang, Yatian; Lan, Qingyuan; Guo, Xiaoxing; Zhang, Liang; Zhi, Yanle; Cai, Jiongheng; Qin, Tianren; Xiang, Li; Wang, Shuxian; Chen, Yadong; Lu, Tao; Lu, Shuai; European Journal of Medicinal Chemistry; vol. 176; (2019); p. 248 – 267;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55121-99-8,(4-Aminophenyl)(4-methylpiperazin-1-yl)methanone,as a common compound, the synthetic route is as follows.

55121-99-8, General Procedure for Synthesis of Examples 8 – 42; EPO EPO EPO The starting pyrimidyl chloride (54 mg, 0.15 mmol) was placed in a 2-5 mL microwave reaction vessel from Personal Chemistry, suspended in iPrOH (2 mL), and treated with concentrated HCI (0.075 mL) and an aniline monomer (0.3 mmol). The vial was sealed and the reaction was heated in the Smith Synthesizer at 170 0C for 20 minutes. The cap was removed and Et3N (0.5 mL) and CH2CI2 (2 mL) were added. The solvent was evaporated and the residue purified by reverse phase mass directed prep HPLC [conditions: 4 x 20 mm Phenomenex Luna C18(2) 3 micron column, eluted with 10-100% Methanol (0.075% Formic Acid) / Water (0.1% Formic Acid), 3 minute gradient time, 4 minute run, 2 ml/minute]. The appropriate fractions were combined and concentrated to give the final products. Compounds with greater than 80% purity by peak area were submitted for screening and are shown in the table below.

55121-99-8 (4-Aminophenyl)(4-methylpiperazin-1-yl)methanone 231408, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2007/18941; (2007); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55121-99-8,(4-Aminophenyl)(4-methylpiperazin-1-yl)methanone,as a common compound, the synthetic route is as follows.

55121-99-8, A mixture of 0.3 g (1.12 mmol) of the product prepared in step 2.6 and 491 mg (2.24 mmol) of the product prepared in step 2.2 in 6 mL of NMP is placed in a 10 mL microwave tube. The sealed tube is placed in a microwave oven (CEM machine, Discover model) and the mixture is heated under pressure at 120 C. for 60 minutes at a power of 75 W, and then cooled to room temperature. 15 mL of water and then 5 mL of saturated aqueous NaHCO3 are added and the precipitate formed is drained by suction and then dried in an oven. The crude solid is purified by chromatography on a column of silica, eluting with a dichloromethane/methanol gradient (100/0 to 90/10). 0.055 g of the expected product is obtained in the form of an orange powder. m.p.=281 C. %. M+H+=451. Yield=11%. 1H NMR (DMSO-d6, 400 MHz): delta 11.8 (broad s, 1H); 10.3 (s, 1H); 10.2 (d, 1H); 9.0 (s, 1H); 8.0 (broad s, 1H); 7.8 (d, 2H); 7.40 (d, 2H); 7.2 (d, 1H); 4.4 (q, 2H); 3.5 (m, 4H); 3.30 (s, 3H); 2.30 (m, 4H); 1.3 (t, 3H).

The synthetic route of 55121-99-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SANOFI; US2012/277220; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics