Category: 53562-86-0

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The configurational relationships between α hydroxy acids and β-hydroxy acids and between the latter and secondary alcohols》. Authors are Levene, P. A.; Haller, H. L..The article about the compound:(S)-Methyl 3-hydroxybutanoatecas:53562-86-0,SMILESS:C[C@H](O)CC(OC)=O).Name: (S)-Methyl 3-hydroxybutanoate. Through the article, more information about this compound (cas:53562-86-0) is conveyed.

It is proposed to study the relation between β-HO acids, α-HO acids and the secondary alcs. by means of the reactions RCH(OH)CH2CO2Et → RCH(OH)CH2NH2 → RCH(OH)CH2OH → RCH(OH)CO2H; RCH(OH)CH2NH2 → RCH(OH)CH2Cl → RCH(OH)CH2CH2CO2H → RCH(OH)Et; RCH(OH)CH2Cl → RCH(OH)Me. Levo-3-hydroxybutyric acid (J. Chem. Soc. 81, 1402(1902)) [α]D25 -24.5°, in H2O. Me Levo-3-hydroxybutyrate (cf. Fischer and Scheibler, C. A. 3, 2135), b17 70-2°, [α]D20 -20.9°, without solvent. Levo-3-hydroxybutyrylhydrazide, C4H10O2N2, m. 129-30°, [α]D31 -29.3°, in EtOH. sym-Dextro-2-hydroxypropylurea, C7H16O3N2, [α]D26.5 18.5°. Levo-2-hydroxypropylamine-HCl, C3H10ONCl, [α]D26.5 -31.2° in H2O, much less in N NaOH, (the last 3 substances were prepared according to methods of Levene and Scheidegger, C. A. 19, 1128, for inactive compounds). Levo-1,2-dihydroxypropane, from the amine, AgNO2 and HCl.

Compound(53562-86-0)Name: (S)-Methyl 3-hydroxybutanoate received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((S)-Methyl 3-hydroxybutanoate), if you are interested, you can check out my other related articles.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about A Bis-Steroidal Phosphine as New Chiral Hydrogenation Ligand, the main research direction is asym hydrogenation bissteroidal phosphine ligand preparation; stereoselective reduction ligand bissteroidal phosphine preparation.Synthetic Route of C5H10O3.

The new atropisomeric bissteroidal ligands R- and S-I are synthesized in 4 steps from the steroid precursor equilenin. The diastereomeric ligands are separable by column chromatog. and exhibit mirror image CD spectra. Likewise, they induce in the chiral reduction of acetophenone to enantiomeric 1-phenylethanols. The synthesis of the phosphine ligands R- and S-I is accomplished by a Ni-mediated cross coupling of the corresponding triflates with Ph2PH. The application of this new bissteroidal phosphine in the hydrogenation of Me acetoacetate, phenylcinnamic acid, and tiglic acid show that the in situ prepared chiral catalyst RuCl2(ligand)(DMF)2 is more active in terms of enantiomeric excess and/or conversion than the corresponding BINAP-derived catalyst.

Compound(53562-86-0)Synthetic Route of C5H10O3 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((S)-Methyl 3-hydroxybutanoate), if you are interested, you can check out my other related articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Formula: C5H10O3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about A kinetic study and application of a novel carbonyl reductase isolated from Rhodococcus erythropolis. Author is Zelinski, Thomas; Kula, Maria-Regina.

The newly described carbonyl reductase from Rhodococcus erythropolis (RECR) accepts a broad range of substrates. Based on the kinetic constants of a variety of Me and Et ketones a hypothetical model of the substrate-binding site is proposed. Whether a substrate of interest may be reduced by the RECR can be predicted from this model together with the kinetic data. A study of initial velocities and product inhibition is presented, which shows that the kinetics of the RECR follow a Theorell-Chance mechanism. The pro-R hydride of NADH is transferred by the enzyme to the re face of the carbonyl compounds yielding (S)-alcs. The reduction of Me 3-oxobutanoate and Et 4-chloro-3-oxobutanoate catalyzed by the oxidoreductase lead to the corresponding hydroxy compounds with high enantiomeric purity [enantiomeric excess (e.e.) ≥99%]. The synthesis of Et (2R,3S)-3-hydroxy-2-methylbutanoate was accomplished with high diastereoselectivity (diastereomeric excess = 95%) and enantioselectivity (e.e. ≥95%).

Compound(53562-86-0)Formula: C5H10O3 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((S)-Methyl 3-hydroxybutanoate), if you are interested, you can check out my other related articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Application In Synthesis of (S)-Methyl 3-hydroxybutanoate. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Durability enhancement of chirally modified metallic nickel catalysts for enantioselective hydrogenation. Author is Osawa, Tsutomu; Kizawa, Tomoko; Lee, I-Yin Sandy; Ikeda, Shinji; Kitamura, Takayuki; Inoue, Yoshihisa; Borovkov, Victor.

Metallic Ni catalysts co-modified with (R,R)-tartaric acid and NaBr showed high enantioselectivity and durability upon hydrogenation of Me acetoacetate to give Me 3-hydroxybutyrate. The chirally modified catalyst prepared from 3-μm Ni powder was highly robust to maintain the hydrogenation activity and enantiodifferentiating ability for ca. 3 mo under dry condition, which enables long-term storage and hence facilitates com. distribution and industrial application.

Compound(53562-86-0)Application In Synthesis of (S)-Methyl 3-hydroxybutanoate received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((S)-Methyl 3-hydroxybutanoate), if you are interested, you can check out my other related articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Safety of (S)-Methyl 3-hydroxybutanoate. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Rhizopus arrhizus mediated asymmetric reduction of alkyl 3-oxobutanoates. Author is Salvi, Neeta A.; Chattopadhyay, Subrata.

Alkyl 3-oxobutanoates MeCOCH2CO2R (R = Me, Et, H2C:CHCH2, Me2CHCH2, Me3C) were reduced enantioselectively to the corresponding (S)-alcs. MeCH(OH)CH2CO2R by the fungus Rhizopus arrhizus and other Rhizopus sp. The best result obtained was with t-Bu 3-oxobutanoate, which was reduced by R. arrhizus with 99% enantiomeric excess and in 68% isolated yield.

Compound(53562-86-0)Safety of (S)-Methyl 3-hydroxybutanoate received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((S)-Methyl 3-hydroxybutanoate), if you are interested, you can check out my other related articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Reference of (S)-Methyl 3-hydroxybutanoate. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Highly Stereoselective Reagents for β-Keto Ester Reductions by Genetic Engineering of Baker’s Yeast. Author is Rodriguez, Sonia; Kayser, Margaret M.; Stewart, Jon D..

While whole cells of baker’s yeast (Saccharomyces cerevisiae) are a convenient biocatalytic reducing agent for a wide variety of carbonyl compounds, mixtures of stereoisomeric alcs. are often observed since the organism contains a large number of reductase enzymes with overlapping substrate specificities but differing stereoselectivities. We sought to improve the performance of baker’s yeast for β-keto ester reductions by using recombinant DNA techniques to alter the levels of three enzymes known to play important roles in these reactions (fatty acid synthase, Fasp; aldo-keto reductase, Ypr1p; α-acetoxy ketone reductase, Gre2p). A complete set of “”first-generation”” yeast strains that either lack or overexpress each of these three enzymes was created and tested for improvements in stereoselective reductions of a series of β-keto esters. On the basis of these results, multiply modified (“”second-generation””) strains were created that combined gene knockout and overexpression in single strains. In some cases, these addnl. modifications further improved the stereoselectivities of β-keto ester reductions, thereby making several β-hydroxy ester building blocks readily available by reactions that can be performed by nonspecialists. This work also revealed that addnl. yeast proteins participate in reducing β-keto esters, and further progress using this strategy will require either addnl. genetic manipulations or the expression of yeast reductases in hosts that lack enzymes with overlapping substrate specificity.

Here is just a brief introduction to this compound(53562-86-0)Reference of (S)-Methyl 3-hydroxybutanoate, more information about the compound((S)-Methyl 3-hydroxybutanoate) is in the article, you can click the link below.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

HPLC of Formula: 53562-86-0. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Simplified preparation of chirally modified nickel catalyst for enantioselective hydrogenation: A step forward to industrial use.

A chirally modified nickel catalyst for the enantio-differentiating hydrogenation of β-ketoesters is conventionally prepared by immersing the pre-activated metallic nickel into an aqueous solution of enantiopure tartaric acid (so called “”modification step””). During the pre-activation step, nickel precursor is commonly treated with hydrogen gas at elevated temperatures of up to 473 K. The X-ray photoelectron spectral examinations of chirally modified nickel catalysts obtained under the different modification conditions revealed that the chiral modification process itself plays a major role in activating the nickel surface while the pre-activation procedure is a less important factor. The corresponding enantio-differentiating hydrogenations of Me acetoacetate in the liquid phase using the prepared chiral catalysts unambiguously confirmed this conclusion, providing quant. conversions and high enantioselectivities of up to 90%.

Here is just a brief introduction to this compound(53562-86-0)HPLC of Formula: 53562-86-0, more information about the compound((S)-Methyl 3-hydroxybutanoate) is in the article, you can click the link below.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Recommanded Product: 53562-86-0. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Determination of the absolute stereostructure of seco-macrosphelide E produced by a fungal strain from a sea hare.

Seco-Macrosphelide E (I) has been isolated from a strain of Periconia byssoides originally separated from the sea hare Aplysia kurodai. Its absolute stereostructure, with the same configuration as that of macrosphelide E, have been elucidated on the basis of spectroscopic analyses and unambiguous synthesis.

Here is just a brief introduction to this compound(53562-86-0)Recommanded Product: 53562-86-0, more information about the compound((S)-Methyl 3-hydroxybutanoate) is in the article, you can click the link below.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The configurational relationships between α hydroxy acids and β-hydroxy acids and between the latter and secondary alcohols》. Authors are Levene, P. A.; Haller, H. L..The article about the compound:(S)-Methyl 3-hydroxybutanoatecas:53562-86-0,SMILESS:C[C@H](O)CC(OC)=O).Name: (S)-Methyl 3-hydroxybutanoate. Through the article, more information about this compound (cas:53562-86-0) is conveyed.

It is proposed to study the relation between β-HO acids, α-HO acids and the secondary alcs. by means of the reactions RCH(OH)CH2CO2Et → RCH(OH)CH2NH2 → RCH(OH)CH2OH → RCH(OH)CO2H; RCH(OH)CH2NH2 → RCH(OH)CH2Cl → RCH(OH)CH2CH2CO2H → RCH(OH)Et; RCH(OH)CH2Cl → RCH(OH)Me. Levo-3-hydroxybutyric acid (J. Chem. Soc. 81, 1402(1902)) [α]D25 -24.5°, in H2O. Me Levo-3-hydroxybutyrate (cf. Fischer and Scheibler, C. A. 3, 2135), b17 70-2°, [α]D20 -20.9°, without solvent. Levo-3-hydroxybutyrylhydrazide, C4H10O2N2, m. 129-30°, [α]D31 -29.3°, in EtOH. sym-Dextro-2-hydroxypropylurea, C7H16O3N2, [α]D26.5 18.5°. Levo-2-hydroxypropylamine-HCl, C3H10ONCl, [α]D26.5 -31.2° in H2O, much less in N NaOH, (the last 3 substances were prepared according to methods of Levene and Scheidegger, C. A. 19, 1128, for inactive compounds). Levo-1,2-dihydroxypropane, from the amine, AgNO2 and HCl.

Compound(53562-86-0)Name: (S)-Methyl 3-hydroxybutanoate received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((S)-Methyl 3-hydroxybutanoate), if you are interested, you can check out my other related articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about A Bis-Steroidal Phosphine as New Chiral Hydrogenation Ligand, the main research direction is asym hydrogenation bissteroidal phosphine ligand preparation; stereoselective reduction ligand bissteroidal phosphine preparation.Synthetic Route of C5H10O3.

The new atropisomeric bissteroidal ligands R- and S-I are synthesized in 4 steps from the steroid precursor equilenin. The diastereomeric ligands are separable by column chromatog. and exhibit mirror image CD spectra. Likewise, they induce in the chiral reduction of acetophenone to enantiomeric 1-phenylethanols. The synthesis of the phosphine ligands R- and S-I is accomplished by a Ni-mediated cross coupling of the corresponding triflates with Ph2PH. The application of this new bissteroidal phosphine in the hydrogenation of Me acetoacetate, phenylcinnamic acid, and tiglic acid show that the in situ prepared chiral catalyst RuCl2(ligand)(DMF)2 is more active in terms of enantiomeric excess and/or conversion than the corresponding BINAP-derived catalyst.

Compound(53562-86-0)Synthetic Route of C5H10O3 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((S)-Methyl 3-hydroxybutanoate), if you are interested, you can check out my other related articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics