Category: 53562-86-0

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Proceedings of the National Academy of Sciences of the United States of America called Remarkably diastereoselective synthesis of a chiral biphenyl diphosphine ligand and its application in asymmetric hydrogenation, Author is Qiu, Liqin; Wu, Jing; Chan, Shusun; Au-Yeung, Terry T.-L.; Ji, Jian-Xin; Guo, Rongwei; Pai, Cheng-Chao; Zhou, Zhongyuan; Li, Xingshu; Fan, Qing-Hua; Chan, Albert S. C., which mentions a compound: 53562-86-0, SMILESS is C[C@H](O)CC(OC)=O, Molecular C5H10O3, Application of 53562-86-0.

Essentially complete atropdiastereoselectivity was realized in the preparation of biaryl diphosphine dioxide by asym. intramol. Ullmann coupling and oxidative coupling with central-to-axial chirality transfer. A bridged C2-sym. biphenylphosphine ligand possessing addnl. chiral centers on the linking unit of the biphenyl groups was synthesized. No resolution step was required for the preparation of the enantiomerically pure chiral ligand. These findings offer a general and practical tool for the development of previously uninvestigated atropdiastereomeric biaryl phosphine ligands. The diphosphine ligand was highly effective in the asym. hydrogenation of α- and β-keto esters, 2-(6′-methoxy-2′-naphthyl)propenoic acid, β-(acylamino)acrylates, and enol acetates.

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Piperazine – Wikipedia,
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Application of 53562-86-0. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Highly Enantioselective Hydrogenation of β-Keto Esters under Mild Conditions. Author is Burk, Mark J.; Harper, T. Gregory P.; Kalberg, Christopher S..

New bis(phospholane)-Ru catalysts have been developed and shown to allow the highly enantioselective hydrogenation of β-keto esters under mild conditions. In particular, the catalyst derived from i-Pr-BPE-RuBr2 [i-Pr-BPE = 1,2-bis(trans-2,5-diisopropylphospholano)ethane] performs efficiently under 60 psig hydrogen and provides a variety of β-hydroxy esters with enantioselectivities in the range 98-99% ee. Enantiomerically pure β-hydroxy esters are key intermediates in the synthesis of chiral phospholane ligands. On this basis, rare examples of “”asym. ligand breeder”” processes have been developed for the self-generative synthesis of the i-Pr-BPE and Cy-BPE ligands.

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Piperazine – Wikipedia,
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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Hirose, Akane; Maeda, Hayato; Tonouchi, Akio; Nehira, Tatsuo; Hashimoto, Masaru researched the compound: (S)-Methyl 3-hydroxybutanoate( cas:53562-86-0 ).Application of 53562-86-0.They published the article 《Neomacrophorin I, II, and III, novel drimenyl cyclohexanes with hydroxylated butanoates from Trichoderma sp. 1212-03》 about this compound( cas:53562-86-0 ) in Tetrahedron. Keywords: neomacrophorin Trichoderma. We’ll tell you more about this compound (cas:53562-86-0).

Neomacrophorins I (1), II (2), and III (3) were isolated from the culture broth of Trichoderma sp. 1212-03 that was collected at Shirakami Mountainous area in Japan. Structural analyses disclosed that these resemble known macrophorins but possess axial-hydroxy group at C3 as well as different side chains at C7′. These are diastereomeric forms of macrophorins for 5′,6′-epoxide functionality. The NMR analyses suggested their relative configurational relationship between the C1-C15 drimene and C1′-C7′ epoxyquinone moieties. ECD spectral discussions verified them particularly for C5′,C6′-epoxyquinone (1), C5′,C6′-epoxysemiquinone (2 and 3), and 2″”,3″”-dihydroxybutanoate moiety in 1 and 2. The configuration of C3″”-stereocenter of 3 was determined by chiral GC-MS after converting into Me (S)-3″”-hydroxybutanoate by basic of 3 methanolysis. Biol. assays disclosed that 1 induces hyphal branching of Cochliobolus miyabeanus as well as cytotoxicity against human colorectal cancer COLO 201.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Reference of (S)-Methyl 3-hydroxybutanoate. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about A new efficient synthesis of both enantiomers of macrosphelide core: A potential precursor for functionalized macrosphelides. Author is Matsuya, Yuji; Kawaguchi, Takanori; Nemoto, Hideo; Nozaki, Hiroshi; Hamada, Hiroki.

The asym. synthesis of a macrosphelide core (I) and its enantiomer was achieved from (S)- or (R)-3-hydroxybutyrate in excellent yields. These compounds are potentially useful precursors for the preparation of biol. important macrosphelide analogs.

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Piperazine – Wikipedia,
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Electric Literature of C5H10O3. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Total synthesis of macrosphelides B and A.

An efficient total synthesis of macrosphelide B (I; R1R2 = O) has been developed in which the C(5)-O(10) and the C(11)-O(16) fragments were prepared from (S)-1-(2-furyl)ethanol of >98% ee via oxidation of the furan part. In addition, macrosphelide B was transformed stereoselectively into macrosphelide A (I; R1 = H, R2 = OH) by reduction followed by Mitsunobu inversion.

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Piperazine – Wikipedia,
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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Practical asymmetric hydrogenation of β-keto esters at atmospheric pressure using chiral Ru(II) catalysts.HPLC of Formula: 53562-86-0.

New practical conditions of asym. hydrogenation of β-keto esters with chiral Ru(II) catalysts are described. It is now possible to carry out the reaction at atm. pressure. Under these conditions, β-keto esters are hydrogenated to β-hydroxy esters with excellent enantiomeric excesses (up to 99%) using chiral ruthenium (II) catalysts easily prepared in situ by treatment of com. available (COD)Ru(2-methylallyl)2 in the presence of the appropriate chiral ligands such as Binap, MeO-Biphep and Me-Duphos.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

HPLC of Formula: 53562-86-0. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Inversion of cpADH5 Enantiopreference and Altered Chain Length Specificity for Methyl 3-Hydroxyalkanoates. Author is Ensari, Yunus; Dhoke, Gaurao V.; Davari, Mehdi D.; Bocola, Marco; Ruff, Anna Joelle; Schwaneberg, Ulrich.

Expanding the substrate scope of enzymes opens up new routes for synthesis of valuable chems. Ketone-functionalized fatty acid derivatives and corresponding chiral alcs. are valuable building blocks for the synthesis of a variety of chems. including pharmaceuticals. The alc. dehydrogenase from Candida parapsilosis (cpADH5) catalyzes the reversible oxidations of chiral alcs. and has a broad substrate range; a challenge for cpADH5 is to convert alcs. with small substituents (Me or ethyl) next to the oxidized alc. moiety. Mol. docking studies revealed that W286 is located in the small binding pocket and limits the access to substrates that contain aliphatic chains longer than Et substituent. In the current manuscript, we report that positions L119 and W286 are key residues to boost oxidation of medium chain Me 3-hydroxy fatty acids; interestingly the enantiopreference toward Me 3-hydroxybutyrate was inverted. Kinetic characterization of W286A showed a 5.5 fold increase of Vmax and a 9.6 fold decrease of Km values toward Me 3-hydroxyhexanoate (Vmax: 2.48 U mg- and Km: 4.76 mM). Simultaneous saturation at positions 119 and 286 library yielded a double mutant (L119M/W286S) with more than 30-fold improved activity toward Me 3-hydroxyoctanoate (WT: no conversion; L119M/W286S: 30 %) and inverted enantiopreference (S-enantiomer ≥99 % activity decrease and R-enantiomer >20-fold activity improvement) toward Me 3-hydroxybutyrate.

If you want to learn more about this compound((S)-Methyl 3-hydroxybutanoate)HPLC of Formula: 53562-86-0, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(53562-86-0).

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics