Category: 53562-86-0

Kluson, Petr; Stavarek, Petr; Penkavova, Vera; Vychodilova, Hana; Hejda, Stanislav; Bendova, Magdalena published an article about the compound: (S)-Methyl 3-hydroxybutanoate( cas:53562-86-0,SMILESS:C[C@H](O)CC(OC)=O ).Recommanded Product: (S)-Methyl 3-hydroxybutanoate. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:53562-86-0) through the article.

Homogeneous asym. catalysts represented by organometallics of transition elements reveal very high activity and stereoselectivity in asym. hydrogenation of β-ketoesters. Recently, it appeared efficient to use ionic liquids of the [NR222][Tf2N] type for accommodation of the chiral catalytic complex. Even on the industrial scale it is becoming attractive to carry out hydrogenations with such immobilized complexes in a continuous regime in microreactors. Attention was paid to the stereoselective hydrogenation of methylacetoacetate (MAA) to isomeric (R)-(+) or (S)-(-)-methyl-3-hydroxybutanoates over a chiral ([RuCl((R)-BINAP)(p-cymene)]Cl) complex immobilized in the mixed [N8222][Tf2N]/methanol/water solvent phase, and performed inside of a microfluidic chip reactor. It was shown that the reaction could be successfully carried out in such an arrangement with a very high enantioselectivity (above 99%) and at very high conversion of MAA (above 97%). It was proven that the participation of a specific solvent (methanol or the mixture [N8222][Tf2N]/methanol/water) essentially influences the mechanism of the reaction. The solvents actively participate in the re-coordination of the catalytic complex in a series of reactions which is reflected in the values of reaction enthalpies. The specific process output was also evaluated.

From this literature《Microfluidic chip reactor and the stereoselective hydrogenation of methylacetoacetate over (R)-Ru-BINAP in the [N8222][Tf2N]/methanol/water mixed phase》,we know some information about this compound(53562-86-0)Recommanded Product: (S)-Methyl 3-hydroxybutanoate, but this is not all information, there are many literatures related to this compound(53562-86-0).

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Challenging the scope of continuous, gas-phase reactions with supported ionic liquid phase (SILP) catalysts-Asymmetric hydrogenation of methyl acetoacetate.Quality Control of (S)-Methyl 3-hydroxybutanoate.

A supported ionic liquid phase (SILP) catalyst was tested in continuous gas phase asym. hydrogenation of Me acetoacetate (MAA); the catalyst is dibromo[3-(2,5-(2R,5R)-dimethylphospholanyl-1)-4-di-o-tolylphosphino-2,5-dimethylthiophene] ruthenium (RuLBr2). The ionic liquid is 1-ethyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide [EMIMNTf2].

From this literature《Challenging the scope of continuous, gas-phase reactions with supported ionic liquid phase (SILP) catalysts-Asymmetric hydrogenation of methyl acetoacetate》,we know some information about this compound(53562-86-0)Quality Control of (S)-Methyl 3-hydroxybutanoate, but this is not all information, there are many literatures related to this compound(53562-86-0).

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-Methyl 3-hydroxybutanoate( cas:53562-86-0 ) is researched.Formula: C5H10O3.Kobayashi, Yuichi; Kumar, G. Biju; Kurachi, Tomoaki; Acharya, Hukum P.; Yamazaki, Takashi; Kitazume, Tomoya published the article 《Furan Ring Oxidation Strategy for the Synthesis of Macrosphelides A and B》 about this compound( cas:53562-86-0 ) in Journal of Organic Chemistry. Keywords: furan ring oxidation macrosphelide A B synthesis. Let’s learn more about this compound (cas:53562-86-0).

By using the convenient protocol for conversion of 2-substituted furans into 4-oxo-2-alkenoic acids ((i) NBS, (ii) NaClO2), macrosphelide B (I, R = H) was synthesized from furyl alc. II (>98% ee) and (S)-Me3CSiMe2OCHMeCH2CO2H (99% ee). Key steps include condensation of (2E,5S)-5-(4-methoxybenzyloxy)-4-oxo-2-hexenoic acid with the furylmethyl ester III and intramol. cyclization of the adduct IV to I (R = MeOCH2). Transformation of I (R = MeOCH2) to macrosphelide A was then investigated. Although the chelation-controlled reduction of I (R = MeOCH2) should afford the desired anti alc., Zn(BH4)2 at <-90 °C gave a 2∼1:1 mixture of anti/syn alcs. On the contrary, reduction with NaBH4 in MeOH at -15 °C produced the syn isomer with >10:1 diastereoselectivity. Mitsunobu inversion of the resulting C(14)-hydroxyl group and deprotection of the MOM group with TFA afforded macrosphelide A. Similarly, reduction of I (R = H) with NaBH4 afforded the C(14)-epimer of macrosphelide A stereoselectively. The observed stereoselectivity in the reductions of I could be explained on the basis of computer-assisted calculation, which showed presence of the low-energy conformers responsible for the stereoselective reduction In addition, conversion of I (R = H) to macrosphelide A was established, for the first time.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-Methyl 3-hydroxybutanoate( cas:53562-86-0 ) is researched.Safety of (S)-Methyl 3-hydroxybutanoate.Ni, Hongliang; Yao, Shanjing published the article 《Biosynthesis of optically active methyl β-hydroxybutanoate by yeast cells》 about this compound( cas:53562-86-0 ) in Huaxue Fanying Gongcheng Yu Gongyi. Keywords: acetoacetate stereoselective reduction hydroxybutyrate yeast fermentation. Let’s learn more about this compound (cas:53562-86-0).

The Me β-hydroxybutanoate (MHB) with optically activity was synthesized by Me acetoacetate (MAA) over different yeasts in aqueous phase. Effects of reaction time, yeast concentration, glucose concentration, buffer pH, reaction temperature and substrate concentration on the yield and the stereoselectivity of (S)-MHB were investigated. The results showed that bakers’ yeast was effective catalyst. The optimal conditions were reaction time 4 h, bakers’ yeast 50 g/L, glucose 0.6 M, substrate MAA 0.05 M, pH 7, 35°. Me β-hydroxybutanoate yield and enantiomeric excess were 57% and 92%, resp.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-Methyl 3-hydroxybutanoate( cas:53562-86-0 ) is researched.SDS of cas: 53562-86-0.Raval, R.; Baddeley, C. J.; Haq, S.; Louafi, S.; Murray, P.; Muryn, C.; Lorenzo, M. Ortega; Williams, J. published the article 《Complexities and dynamics of the enantioselective active site in heterogeneous catalysis》 about this compound( cas:53562-86-0 ) in Studies in Surface Science and Catalysis. Keywords: copper catalyst surface modified chiral mol activity; hydrogenation ketoester enantioselective site catalyst mechanism; methylacetoacetate hydrogenation stereocontrol chiral catalyst site. Let’s learn more about this compound (cas:53562-86-0).

Stereocontrol mechanisms in chirally modified metals in heterogeneous catalysis for enantioselective reactions were studied. Effective systems were produced by first modifying a metal surface with chiral mols. and, subsequently, conducting the enantioselective reaction on the modified surface. The asym. hydrogenation of β-ketoesters (methylacetoacetate) over R,R-tartaric acid and S-alanine modified Cu(110) surfaces was used as model. The products are S and R-methyl-3-hydroxybutyrates. Surface spectroscopy methods were used to characterize modified surfaces created under ultra-clean and controlled environments; the adsorbed modifiers, R,R-tartaric acid and S-alanine, display rich and complex phase diagrams in which the chem. nature and 2-dimensional organization of the chiral units varies considerably as a function of surface coverage and temperature The models suggested for stereocontrol involving one-to-one interaction between the adsorbed chiral modifier and the reactant (substrate) are, perhaps, too simplistic and careful account needs to be taken of the complexities and dynamic interplay between different modifier phases at a surface to fully understand the nature and scope of stereocontrol.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Kluson, Petr; Stavarek, Petr; Penkavova, Vera; Vychodilova, Hana; Hejda, Stanislav; Bendova, Magdalena published an article about the compound: (S)-Methyl 3-hydroxybutanoate( cas:53562-86-0,SMILESS:C[C@H](O)CC(OC)=O ).Recommanded Product: (S)-Methyl 3-hydroxybutanoate. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:53562-86-0) through the article.

Homogeneous asym. catalysts represented by organometallics of transition elements reveal very high activity and stereoselectivity in asym. hydrogenation of β-ketoesters. Recently, it appeared efficient to use ionic liquids of the [NR222][Tf2N] type for accommodation of the chiral catalytic complex. Even on the industrial scale it is becoming attractive to carry out hydrogenations with such immobilized complexes in a continuous regime in microreactors. Attention was paid to the stereoselective hydrogenation of methylacetoacetate (MAA) to isomeric (R)-(+) or (S)-(-)-methyl-3-hydroxybutanoates over a chiral ([RuCl((R)-BINAP)(p-cymene)]Cl) complex immobilized in the mixed [N8222][Tf2N]/methanol/water solvent phase, and performed inside of a microfluidic chip reactor. It was shown that the reaction could be successfully carried out in such an arrangement with a very high enantioselectivity (above 99%) and at very high conversion of MAA (above 97%). It was proven that the participation of a specific solvent (methanol or the mixture [N8222][Tf2N]/methanol/water) essentially influences the mechanism of the reaction. The solvents actively participate in the re-coordination of the catalytic complex in a series of reactions which is reflected in the values of reaction enthalpies. The specific process output was also evaluated.

From this literature《Microfluidic chip reactor and the stereoselective hydrogenation of methylacetoacetate over (R)-Ru-BINAP in the [N8222][Tf2N]/methanol/water mixed phase》,we know some information about this compound(53562-86-0)Recommanded Product: (S)-Methyl 3-hydroxybutanoate, but this is not all information, there are many literatures related to this compound(53562-86-0).

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Challenging the scope of continuous, gas-phase reactions with supported ionic liquid phase (SILP) catalysts-Asymmetric hydrogenation of methyl acetoacetate.Quality Control of (S)-Methyl 3-hydroxybutanoate.

A supported ionic liquid phase (SILP) catalyst was tested in continuous gas phase asym. hydrogenation of Me acetoacetate (MAA); the catalyst is dibromo[3-(2,5-(2R,5R)-dimethylphospholanyl-1)-4-di-o-tolylphosphino-2,5-dimethylthiophene] ruthenium (RuLBr2). The ionic liquid is 1-ethyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide [EMIMNTf2].

From this literature《Challenging the scope of continuous, gas-phase reactions with supported ionic liquid phase (SILP) catalysts-Asymmetric hydrogenation of methyl acetoacetate》,we know some information about this compound(53562-86-0)Quality Control of (S)-Methyl 3-hydroxybutanoate, but this is not all information, there are many literatures related to this compound(53562-86-0).

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis of the dibenzofuran-based diphosphine ligand BIFAP and its water-soluble derivative BIFAPS and their use in ruthenium-catalyzed asymmetric hydrogenation., published in 1999-09-30, which mentions a compound: 53562-86-0, Name is (S)-Methyl 3-hydroxybutanoate, Molecular C5H10O3, Application of 53562-86-0.

The syntheses of both enantiomers of the novel diphosphine ligand 2,2′-bis(diphenylphosphino)-1,1′-bidibenzofuranyl (BIFAP) and the water-soluble analog (-)-2,2′-bis(diphenylphosphino)-1,1′-bidibenzofuranyl-8,8′-disulfonic acid dipotassium salt (BIFAPS) are reported. Advantage is taken of the very high regioselectivity in ring functionalization of the 1,1′-bidibenzofuranyl backbone. These ligands were used in the Ru-catalyzed hydrogenation of Me acetoacetate and (Z)-acetamidocinnamic acid in MeOH and H2O. In MeOH both BIFAP and BIFAPS give the products in very high enantiomeric excess. With BIFAPS in H2O a slight drop in the ee of the products is observed When BIFAPS was used with either H2O or MeOH as the solvent the addition of a small amount of acid turns out to be essential for a fast reaction and high asym. induction.

There is still a lot of research devoted to this compound(SMILES：C[C@H](O)CC(OC)=O)Application of 53562-86-0, and with the development of science, more effects of this compound(53562-86-0) can be discovered.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 53562-86-0, is researched, Molecular C5H10O3, about Acclimatization of Baker’s Yeast for Asymmetric Reduction at High Substrate Concentration, the main research direction is Saccharomyces stereoselective reduction acclimatization high substrate.HPLC of Formula: 53562-86-0.

By gradually adding a low content of Me acetoacetate into a solid medium, a new yeast strain, called MAA yeast, was separated from com. baker’s yeast. The new yeast was used for catalyzing asym. reduction of Me acetoacetate in the aqueous phase, and results showed that it was more efficient than regular baker’s yeast in the asym. reduction of Me acetoacetate. The influence of external environment, pH, and temperature on MAA yeast was the same as on baker’s yeast. The yield of Me β-hydroxybutanoate with the new strain was about 13% higher than with baker’s yeast at 0.05 M Me acetoacetate. Similar results were also obtained in experiments, when MAA yeast was used to catalyze other systems, such as reducing Et 4-chloro-3-oxobutanoate to (S)-4-chloro-3-hydroxybutanoate and reducing Et acetoacetate to Et (S)-3-hydroxybutyrate. In addition, the main product was (S)-Me β-hydroxybutanoate at low substrate concentration; however, (R)-Me β-hydroxybutanoate would be obtained when the concentration of substrate exceeded 0.4 M. The morphol. of the new strain is the same as that of baker’s yeast.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthetic Route of C5H10O3. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about High Enantioselectivity and Broad Substrate Specificity of a Carbonyl Reductase: Toward a Versatile Biocatalyst.

A carbonyl reductase isolated from bakers’ yeast shows high stereoselectivity and chemoselectivity in the reduction of carbonyl compounds in the presence of an ester group or a second carbonyl group. The results are compared with those obtained with whole cell reduction with bakers’ yeast.

There is still a lot of research devoted to this compound(SMILES：C[C@H](O)CC(OC)=O)Synthetic Route of C5H10O3, and with the development of science, more effects of this compound(53562-86-0) can be discovered.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics