Category: 53562-86-0

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (S)-Methyl 3-hydroxybutanoate(SMILESS: C[C@H](O)CC(OC)=O,cas:53562-86-0) is researched.Quality Control of 2-(Thiophen-3-yl)-1,3-dioxolane. The article 《Difluorphos, an electron-poor diphosphane: A good match between electronic and steric features》 in relation to this compound, is published in Angewandte Chemie, International Edition. Let’s take a look at the latest research on this compound (cas:53562-86-0).

Both enantiomers of difluorphos I were synthesized and their stereoelectronic features were evaluated in theor. and exptl. studies. The unusual π acidity of I explains the excellent results obtained with it in ruthenium-mediated asym. hydrogenation of fluorinated β-functionalized ketones. These results are better than those obtained with other biphenyl-based diphosphines.

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Product Details of 53562-86-0. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Microreactors and microfluidic reactors for synthesis of fine chemicals. Author is Kluson, P.; Stavarek, P.; Hejda, S.; Penkavova, V.; Bendova, M.; Vychodilova, H..

The primary intention of this work was to bring information on the research, development, and construction of advanced microreactor platforms for the syntheses of fine chems. A brief overview was provided on the systems used for practical gas and liquid phase reactions, homogeneous and heterogeneous catalytic reactions, polymerizations, and also for reactions with involvement of light. Then an attention was paid to the tubular continuous microreactors, especially to those which are usually referred to as microfluidic chips. In the past, these microfluidic reactors have been used for various organic reactions in the field of fine chem. Finally, an algorithm has been described for a validation of the microtluidic reactor platform for flow conditions of specific solvents mixtures used in stereoselective hydrogenation of β-ketoesters with chiral metal complexes, and in the presence of specific ionic liquids

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 53562-86-0, is researched, Molecular C5H10O3, about Enantioselective hydrogenation of β-keto esters with monodentate ligands, the main research direction is keto ester hydrogenation ruthenium chiral monodentate phosphine; hydroxy ester asym preparation; ruthenium chiral monodentate phosphine asym hydrogenation catalyst.Product Details of 53562-86-0.

Efficient and stable chiral monodentate phosphine ligands can be used in the ruthenium-catalyzed enantioselective hydrogenation of β-keto esters. The catalysts were remarkably temperature-tolerant, and high enantioselectivities were possible, even at 100-120°C.

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Piperazine – Wikipedia,
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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Herzberg, Gene R.; Rogerson, Minda researched the compound: (S)-Methyl 3-hydroxybutanoate( cas:53562-86-0 ).Application In Synthesis of (S)-Methyl 3-hydroxybutanoate.They published the article 《Use of alcohol oxidase to measure the methanol produced during the hydrolysis of D- and L-methyl-3-hydroxybutyric acid》 about this compound( cas:53562-86-0 ) in Analytical Biochemistry. Keywords: methanol enzymic determination alc oxidase; alc primary enzymic determination oxidase; methyl hydroxybutyrate hydrolysis alc oxidase. We’ll tell you more about this compound (cas:53562-86-0).

An enzymic assay for the measurement of MeOH was developed. The assay uses alc. oxidase and peroxidase coupled to the oxidation of 2,2′-azino-di-(3-ethyl)-benzthiazoline-6-sulfonic acid as the chromogen. The assay is linear up to 50 nmol MeOH in a 200-μL sample and sensitive; 1.25 nmol of MeOH in a 200-μL sample can be measured. The assay is rapid and measurements can be made at any convenient time between 15 min and 4 h after initiation of the reaction. The assay shows highest activity with MeOH but significant activity with other primary alcs. up to 1-butanol. Little activity is shown with secondary alcs. and diols. This assay was used to follow the hydrolysis of the 2 isomers of the Me ester of 3-hydroxybutyric acid.

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Genet, J. P.; Pinel, C.; Ratovelomanana-Vidal, V.; Mallart, S.; Pfister, X.; Bischoff, L.; Cano De Andrade, M. C.; Darses, S.; Galopin, C. published an article about the compound: (S)-Methyl 3-hydroxybutanoate( cas:53562-86-0,SMILESS:C[C@H](O)CC(OC)=O ).Application of 53562-86-0. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:53562-86-0) through the article.

The new class of 2-methylallyl ruthenium chiral diphosphines (P*P)RuII(2-methylallyl)2 (1, P*P = chiral diphosphine) are efficient in asym. hydrogenation of α,β unsaturated acids and allylic alcs. The related chiral halogen-containing ruthenium catalysts (P*P)RuIIX2 (X = halogen) are prepared from 1 or in situ from (COD)Ru[η3-(CH2)2CHCH3]2 by ligand exchange with the chelating diphosphine followed by protonation (HX) in acetone. This procedure allows rapid screening of chiral phosphines, such as Diop, Chiraphos, Cbd, Bppm, Binap, β-glucophos, Biphemp, MeO-Biphep, Me-Duphos, in ruthenium mediated hydrogenations of prochiral substrates. A high efficiency is displayed by Ru-catalysts having atropisomeric ligands (e.e. up to 99%) and a C2 sym. bis(phospholane) has also emerged as a valuable ligand (Me-Duphos, e.e. up to 87% not optimized). Asym. hydrogenation of β-keto esters can be conducted under quite mild conditions (4 atm. of H2, 50°, e.e. up to 99%). β-Keto esters having a disubstituted double bond are also hydrogenated chemoselectively to unsaturated chiral alcs. under controlled conditions with excellent optical purities.

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Quality Control of (S)-Methyl 3-hydroxybutanoate. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Analysis of optical rotatory dispersion and circular dichroism of the helical conformation of poly(β-hydroxybutyrate) in solution. Author is Delsarte, J.; Weill, G..

The rotary strengths of the n-π* transition of the carbonyl chromophore of poly(β-hydroxybutyrate) in trifluoroethanol was at least twice as intense as that in model compounds, and the π-π transition was split into 2 bands. The use of ORD and CD measurements for the determination of the conformation of the polymer was discussed.

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Computed Properties of C5H10O3. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about CH-stretching vibrational circular dichroism of α-hydroxy acids and related molecules.

A conference; Vibrational CD (VCD) spectra of chiral α-hydroxy acids and related mols. have been investigated in the hydrogen stretching and mid-IR regions to probe factors influencing the VCD intensity of methine and hydroxyl stretching and bending motions. Ab initio calculations were carried out to identify low energy conformers and to calculate VCD intensity with the vibronic coupling VCD theory, utilizing DFT normal modes and geometry. Large methine stretching VCD intensity was correlated with the presence of an oxygen at the chiral center in conjunction with an O=C-C*-O dihedral angle near 0°. Vibrational transition CD plots for the methine stretch in deuterated Me lactate reveal angular and circulatory charge flow consistent with the pos. rotational strength for the S-enantiomer.

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Piperazine – Wikipedia,
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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-Methyl 3-hydroxybutanoate( cas:53562-86-0 ) is researched.Formula: C5H10O3.Kobayashi, Yuichi; Kumar, G. Biju; Kurachi, Tomoaki; Acharya, Hukum P.; Yamazaki, Takashi; Kitazume, Tomoya published the article 《Furan Ring Oxidation Strategy for the Synthesis of Macrosphelides A and B》 about this compound( cas:53562-86-0 ) in Journal of Organic Chemistry. Keywords: furan ring oxidation macrosphelide A B synthesis. Let’s learn more about this compound (cas:53562-86-0).

By using the convenient protocol for conversion of 2-substituted furans into 4-oxo-2-alkenoic acids ((i) NBS, (ii) NaClO2), macrosphelide B (I, R = H) was synthesized from furyl alc. II (>98% ee) and (S)-Me3CSiMe2OCHMeCH2CO2H (99% ee). Key steps include condensation of (2E,5S)-5-(4-methoxybenzyloxy)-4-oxo-2-hexenoic acid with the furylmethyl ester III and intramol. cyclization of the adduct IV to I (R = MeOCH2). Transformation of I (R = MeOCH2) to macrosphelide A was then investigated. Although the chelation-controlled reduction of I (R = MeOCH2) should afford the desired anti alc., Zn(BH4)2 at <-90 °C gave a 2∼1:1 mixture of anti/syn alcs. On the contrary, reduction with NaBH4 in MeOH at -15 °C produced the syn isomer with >10:1 diastereoselectivity. Mitsunobu inversion of the resulting C(14)-hydroxyl group and deprotection of the MOM group with TFA afforded macrosphelide A. Similarly, reduction of I (R = H) with NaBH4 afforded the C(14)-epimer of macrosphelide A stereoselectively. The observed stereoselectivity in the reductions of I could be explained on the basis of computer-assisted calculation, which showed presence of the low-energy conformers responsible for the stereoselective reduction In addition, conversion of I (R = H) to macrosphelide A was established, for the first time.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-Methyl 3-hydroxybutanoate( cas:53562-86-0 ) is researched.Safety of (S)-Methyl 3-hydroxybutanoate.Ni, Hongliang; Yao, Shanjing published the article 《Biosynthesis of optically active methyl β-hydroxybutanoate by yeast cells》 about this compound( cas:53562-86-0 ) in Huaxue Fanying Gongcheng Yu Gongyi. Keywords: acetoacetate stereoselective reduction hydroxybutyrate yeast fermentation. Let’s learn more about this compound (cas:53562-86-0).

The Me β-hydroxybutanoate (MHB) with optically activity was synthesized by Me acetoacetate (MAA) over different yeasts in aqueous phase. Effects of reaction time, yeast concentration, glucose concentration, buffer pH, reaction temperature and substrate concentration on the yield and the stereoselectivity of (S)-MHB were investigated. The results showed that bakers’ yeast was effective catalyst. The optimal conditions were reaction time 4 h, bakers’ yeast 50 g/L, glucose 0.6 M, substrate MAA 0.05 M, pH 7, 35°. Me β-hydroxybutanoate yield and enantiomeric excess were 57% and 92%, resp.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-Methyl 3-hydroxybutanoate( cas:53562-86-0 ) is researched.SDS of cas: 53562-86-0.Raval, R.; Baddeley, C. J.; Haq, S.; Louafi, S.; Murray, P.; Muryn, C.; Lorenzo, M. Ortega; Williams, J. published the article 《Complexities and dynamics of the enantioselective active site in heterogeneous catalysis》 about this compound( cas:53562-86-0 ) in Studies in Surface Science and Catalysis. Keywords: copper catalyst surface modified chiral mol activity; hydrogenation ketoester enantioselective site catalyst mechanism; methylacetoacetate hydrogenation stereocontrol chiral catalyst site. Let’s learn more about this compound (cas:53562-86-0).

Stereocontrol mechanisms in chirally modified metals in heterogeneous catalysis for enantioselective reactions were studied. Effective systems were produced by first modifying a metal surface with chiral mols. and, subsequently, conducting the enantioselective reaction on the modified surface. The asym. hydrogenation of β-ketoesters (methylacetoacetate) over R,R-tartaric acid and S-alanine modified Cu(110) surfaces was used as model. The products are S and R-methyl-3-hydroxybutyrates. Surface spectroscopy methods were used to characterize modified surfaces created under ultra-clean and controlled environments; the adsorbed modifiers, R,R-tartaric acid and S-alanine, display rich and complex phase diagrams in which the chem. nature and 2-dimensional organization of the chiral units varies considerably as a function of surface coverage and temperature The models suggested for stereocontrol involving one-to-one interaction between the adsorbed chiral modifier and the reactant (substrate) are, perhaps, too simplistic and careful account needs to be taken of the complexities and dynamic interplay between different modifier phases at a surface to fully understand the nature and scope of stereocontrol.

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Piperazine – Wikipedia,
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