Category: 511254-92-5

Sep 2021 News Some tips on (S)-1-Benzyl-2-methylpiperazine

511254-92-5 (S)-1-Benzyl-2-methylpiperazine 28406010, apiperazines compound, is more and more widely used in various fields.

511254-92-5, (S)-1-Benzyl-2-methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

511254-92-5, Step 3: (S)-1-benzyl-2-methyl-4-(1-methylpiperidin-4-yl)piperazine (S)-1-Benzyl-2-methylpiperazine (6.84 g, 36 mmol), 1-methyl-4-piperidone (4.87 g, 43 mmol), and glacial acetic acid (4.32 g, 72 mmol) were successively added to anhydrous ethanol (100 mL). The resultant was stirred for 1 hour, and then cooled to 0C. Sodium triacetoxyborohydride (31.6 g, 150 mmol) was added in portions. The resultant was reacted at room temperature for 6 hours. The solvent was evaporated, and the residue was dissolved by adding ethyl acetate. The resultant was washed by water, dried, concentrated, and purified by silica gel column chromatography to give (S)-1-benzyl-2-methyl-4-(1-methylpiperidin-4-yl)piperazine (7.86 g, 76% yield). MS m/z [ESI]: 288.2 [M+1].

511254-92-5 (S)-1-Benzyl-2-methylpiperazine 28406010, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Chia Tai Tianqing Pharmaceutical Group Co.,Ltd; Centaurus BioPharma Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.; XIAO, Dengming; XU, Xinhe; LIU, Xijie; HU, Yuandong; YU, Honghao; LIU, Zhihua; PENG, Yong; SUN, Yinghui; LUO, Hong; KONG, Fansheng; HAN, Yongxin; SUN, Jian; EP2952510; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

Brief introduction of 511254-92-5

The synthetic route of 511254-92-5 has been constantly updated, and we look forward to future research findings.

511254-92-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.511254-92-5,(S)-1-Benzyl-2-methylpiperazine,as a common compound, the synthetic route is as follows.

Step 3. (S)-tert-Butyl 4-(4-benzyl-3-methylpiperazin-1-yl)-4-cyanopiperidine-1-carboxylate (24). To a stirred solution of 22 (21.22 g, 111.52 mmol) in dichloromethane (65 mL) was added 1-Boc-4-piperidone (23) (22.22 g, 111.52 mmol) in one portion. Titanium tetraisopropoxide (45.75 mL, 44.38 g, 156.13 mmol) was added dropwise over 30 minutes while the mixture was agitated with a mechanical stirrer at room temperature. After 21 hours, tetrahydrofuran (115 mL) was added. A 1.0 M solution of diethylaluminum cyanide (117.10 mL, 117.10 mmol) was added dropwise over 20 minutes. The mixture was stirred at room temperature for 20 hours then cooled to 0 C. Ethyl acetate (113 mL) was added dropwise over 10 minutes. Celite (11 g) was added, followed by sodium bicarbonate (47 g) and saturated aqueous sodium sulfate solution (11 mL) over 20 minutes. Methanol (70 mL) was added and the mixture was filtered through Celite and concentrated under reduced pressure to give 36.94 g (83%) of 24 as a beige, waxy solid.

The synthetic route of 511254-92-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CoNCERT Pharmaceuticals, Inc.; US2009/270336; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics