Category: 50606-32-1piperazines

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50606-32-1,Butyl piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.,50606-32-1

Example 11: (lalpha,5alpha,6beta)-3-{6-[(S)-l-(4-Butoxycarbonyl-piperazine-l-carbonyl)-2- methyl-propylcarbamoyll^-phenyl-pyrimidin^-ylJ-S-aza-bicyclop.l.Olhexane– carboxylic acid:11.1. 4-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyryl)-piperazine-l-carboxylic acid butyl ester:To a solution of Boc-(L)-Val-OH (400 mg) in DCM (12 mL) were added DIPEA (0.991 mL), DMAP (22 mg), HOBT hydrate (298 mg), EDCI hydrochloride (423 mg) and intermediate 1.4 (343 mg). The mixture was stirred at RT for 6 h. An aq. NaHCO3 solution was added to the mixture and the phases were separated. The org. phase was washed with brine, dried (MgStheta4) and evaporated off to afford 844 mg of the desired compound as beige oil. LC-MS: tR = 1.02 min; [M+H]+: 386.42.

The synthetic route of 50606-32-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ACTELION PHARMACEUTICALS LTD; CAROFF, Eva; HILPERT, Kurt; HUBLER, Francis; MEYER, Emmanuel; RENNEBERG, Dorte; WO2010/116328; (2010); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

50606-32-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50606-32-1,Butyl piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

8.3. 4-[(R)-2-tert-Butoxycarbonylamino-3-(diethoxy-phosphoryl)-propionyl]-piperazine-l- carboxylic acid butyl esterTo a solution of intermediate 8.2 (7.37 g) in CH2Cl2 (95 mL), THF (24 mL) and DIPEA (16.3 mL) were added HOBT (3.83 g) and EDCI-HCl (4.78 g), and the reaction mixture was stirred at RT for 10 min. Subsequently, piperazine- 1 -carboxylic acid butyl ester (5.31 g) was added and the mixture stirred at RT for 2.5 h. The reaction mixture was diluted with CH2Cl2, the org. phase washed with sat. aq. NaHCO3 and the aq. phase re-extracted with CH2Cl2. The combined org. phases were washed with brine, dried over Na2SO^ and concentrated to dryness. Purification by CC (EtOAc/MeOH 1 :0 to 9: 1) gave 7.66 g of the desired product. LC-MS: tR = 0.94 min; [M+H]+: 494.00.

As the paragraph descriping shows that 50606-32-1 is playing an increasingly important role.

Reference£º
Patent; ACTELION PHARMACEUTICALS LTD; CAROFF, Eva; HILPERT, Kurt; HUBLER, Francis; LEHMANN, David; MEYER, Emmanuel; RENNEBERG, Dorte; WO2010/122504; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

50606-32-1, Butyl piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50606-32-1, 56.2. 4-[2-Benzyloxycarbonylamino-2-(dimethoxy-phosphoryl)-acetyl]-piperazine-l- carboxylic acid butyl ester: To a solution of intermediate 56.1 (1.5 g) in DCM (5 mL) was added DIPEA (3.4 mL) and HATU (2.2 g). After stirring at RT for 10 min, intermediate 2.2 (1.1 g) was added. The reaction mixture was stirred overnight at RT and H2O was added. The phases were separated, the org. phase was washed with sat NaCl solution, dried (MgStheta4) and evaporated off. The crude was purified by CC (Hept/EA 2/8) to afford the desired compound (1.1 g). LC-MS (A): tR = 0.95 min; [M+H]+: 486.01.

The synthetic route of 50606-32-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ACTELION PHARMACEUTICALS LTD; WO2009/69100; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics