Category: 50606-32-1

50606-32-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50606-32-1,Butyl piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

1.5. 4-((S)-2-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyryl)-piperazine-l- carboxylic acid butyl ester: CbZ-(L)GIu(OtBu)-OH (10 g), HOBT hydrate (5 g), EDCI hydrochloride (6.3 g), intermediate 1.4 (6 g) and DIPEA (10 mL) were dissolved in DCM/THF (1/1, 84 mL). The mixture was stirred at RT for 1 h. DCM and an aq. NaHCO3 solution were added to the mixture and the phases were separated. The org. phase was washed with a M NaHStheta4 solution, dried (Na2SO^ and evaporated off. CC of the crude (EA/Hept 1/2) offered 13.8 g of the desired compound.LC-MS: tR = 1.04 min; [M+H]+: 506.49.

50606-32-1 Butyl piperazine-1-carboxylate 21963126, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ACTELION PHARMACEUTICALS LTD; CAROFF, Eva; HILPERT, Kurt; HUBLER, Francis; MEYER, Emmanuel; RENNEBERG, Dorte; WO2010/116328; (2010); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

50606-32-1, Butyl piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50606-32-1, PREPARATION 8: Preparation of piperazine-1-carboxylic acid methylamide 11 g (59 mmol) of N-butyloxycarbonylpiperazine was dissolved in 250 ml of anhydrous tetrahydrofuran, and then 20.6 ml (118 mmol) of N,N-diisopropylethylamine and 13.1 g (64.9 mmol) of 4-nitrophenylchloroformate were added thereto, followed by stirring under reflux for 1 hour. 177 ml of methylamine (2 M tetrahydrofuran solution) was added to the reaction, followed by stirring under reflux for 30 minutes. After completion of the reaction, the reaction solution was concentrated, after addition of 100 ml of water, and then extracted twice with 100 ml of dichloromethane. 30 ml of 4 N hydrochloric acid/l,4-dioxane solution was added thereto, followed by stirring for 5 hours at room temperature. A solid, which was produced from completion of the reaction, was filtered off and dried to obtain 9.53 g (53 mmol, yield of 90%) of the title compound as hydrochloride salt.1H NMR (DMSOd6, ppm); delta 9.28 (IH, bs), 7.94 (IH, bs), 3.52 (4H, m), 3.01 (4H, m), 2.57 (3H, s)FAB MS(m/e) = 144 [M+l]

The synthetic route of 50606-32-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; LG LIFE SCIENCES, LTD.; WO2007/58482; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

50606-32-1, Butyl piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50606-32-1, Example 33: (lalpha,5alpha,6beta)-3-{6-[2-(4-Butoxycarbonyl-piperazin-l-yl)-2-oxo- ethylcarbamoyl]-2-phenyl-pyrimidin-4-yl}-3-aza-bicyclo[3.1.0]hexane-6-carboxylic acid:33.1 4-(2-tert-Butoxycarbonylamino-acetyl)-piperazine-l-carboxylic acid butyl ester:To a solution of Boc-Glycine (2351 mg) in DCM (150 mL) were added HOBT hydrate (2358 mg) and EDCI hydrochloride (3100 mg) and the mixture was stirred for 30 min at RT. Intermediate 1.4 (2500 mg) was then added and the reaction mixture was stirred at RT overnight. A IN NaHStheta4 aqueous solution was added to the mixture, the formed solid was filtered off and the 2 phases of the filtrate were separated. The org. phase was washed with sat. Na2CO3 solution, dried (MgSO^ and evaporated off to afford 4620 mg of the desired compound as white solid. LC-MS: tR = 0.92 min; [M+H]+: 344.27.

As the paragraph descriping shows that 50606-32-1 is playing an increasingly important role.

Reference£º
Patent; ACTELION PHARMACEUTICALS LTD; CAROFF, Eva; HILPERT, Kurt; HUBLER, Francis; MEYER, Emmanuel; RENNEBERG, Dorte; WO2010/116328; (2010); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50606-32-1,Butyl piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

50606-32-1, 3.2. 4-((S)-2-tert-Butoxycarbonylamino-4-ethoxycarbonyl-butyryl)-piperazine-l-carboxylic acid butyl ester To a solution of intermediate 3.1 (8.75 g) in CH2Cl2 (50 mL) / THF (20 mL) was added HOBT (4.94 g). After 15 min, was added EDCI-HCl (6.70 g) and the reaction mixture further stirred for 20 min. Piperazine-1-carboxylic acid butyl ester (6.22 g, prepared as described in WO2008044217) was added and the reaction mixture stirred until reaction completion at RT. The mixture was poured onto an ice-cold aq. citric acid solution (5%), and the precipitate filtered off. The filtrate was extracted with Et2O (3×200 mL), the org. phase washed with aq. citric acid (5%, 4×50 niL), sat. aq. Na2CO3 solution and brine. The combined org. layers were dried over MgSO4 and evaporated to give 13.O g of the desired product. LC-MS: tR = 1.01 min; [M+H]+: 444.49.

50606-32-1 Butyl piperazine-1-carboxylate 21963126, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ACTELION PHARMACEUTICALS LTD; CAROFF, Eva; HILPERT, Kurt; HUBLER, Francis; LEHMANN, David; MEYER, Emmanuel; RENNEBERG, Dorte; WO2010/122504; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

50606-32-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50606-32-1,Butyl piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

-Methyl^^tmethyKS.ej.S-tetrahydro-S-quinolinyOaminolmethylJ-IH-benzimidazole-4-carboxylic acid (100 mg, 0.29 mmol), bis(2-oxo-3-oxazolidinyl)phosphinic chloride(109 mg, 0.43 mmol), W-butoxycarbonylpiperizine (80, 0.43 mmol), and N,N-diisopropyl-ethylamine

As the paragraph descriping shows that 50606-32-1 is playing an increasingly important role.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2006/23400; (2006); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics