Category: 438049-91-3

Brief introduction of 438049-91-3

The synthetic route of 438049-91-3 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.438049-91-3,(3R,5R)-tert-Butyl 3,5-dimethylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.,438049-91-3

To a solution of 1 -bromo-4-fluoro-2-methoxybenzene (910 mg, 4.4 mmol) and 1 M KHMDS (18 ml_, 18 mmol) in 1 ,4-dioxane (9 mL) was added tert- butyl (3R,5R)- 3,5- dimethylpiperazine-1 -carboxylate (950 mg, 4.4 mmol). The reaction mixture was stirred at 100 C for 3 h. The solvent was removed and the residue was purified by column chromatography (petroleum ether/EtOAc = 20:1 ) to provide tert- butyl {3R,5R)- 4-(3-fluoro-5- methoxyphenyl)-3,5-dimethylpiperazine-1 – carboxylate. LC-MS (ESI): m/z 339.0 [M+H]+.

The synthetic route of 438049-91-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; KEZAR LIFE SCIENCES; JOHNSON, Henry; (166 pag.)WO2019/178510; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

Simple exploration of (3R,5R)-tert-Butyl 3,5-dimethylpiperazine-1-carboxylate

438049-91-3 (3R,5R)-tert-Butyl 3,5-dimethylpiperazine-1-carboxylate 51670829, apiperazines compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.438049-91-3,(3R,5R)-tert-Butyl 3,5-dimethylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.,438049-91-3

A mixture of (3S,5R)-tert-butyl 3,5-dimethylpiperazine-l-carboxylate (2.14g, 10.0 mmol), 3-bromopropan-l-ol (2.76 g, 20 mmol) and K2C03(2.76 g, 20 mmol) in DMF (5.0 mL) was heated to 90C for 2 h in a microwave. The reaction mixture was poured into water (30 mL) and extracted with EtOAc. The organic phase was separated, dried and concentrated. The residue was purified by chromatography (DCM:MeOH=30: 1) to provide (3R,5S)-tert-butyl 4-(3- hydroxypropyl)-3,5-dimethylpiperazine-l-carboxylate as a yellow liquid (2.14g, 50%).

438049-91-3 (3R,5R)-tert-Butyl 3,5-dimethylpiperazine-1-carboxylate 51670829, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; PRINCIPIA BIOPHARMA INC.; BRAMELD, Kenneth Albert; VERNER, Erik; (122 pag.)WO2016/191172; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics