Category: 4318-42-7

4318-42-7,4318-42-7, 1-Isopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step B: r5-(4-lsopropyl-piperazine-1 -carbonvD-benzoribithiophen-3-yli- piperidin-1 -yl-methanone; . To a suspension of (5-bromo-benzo[iotab]thiophen-3-yl)- piperidin-1 -yl-methanone (370 mg, 1.2 mmol), 1 -isopropyl-piperazine (147 mg, 1.2 mmol), Na2CO3 (607 mg, 5.7 mmol), and Hermann’s catalyst (54 mg, 0.06 mmol) in H2O (2 ml_) was added Mo(CO)6 (151 mg, 0.57 mmol) and the reaction mixture was sealed and heated at 130 0C with microwave irradiation for 10 min. The solution was concentrated and the resulting residue was partitioned betweenEtOAc and 1 N NaOH (50 ml_). The organic layer was washed with brine (50 ml_), dried, and concentrated. The resulting residue was purified by FCC to provide 193 mg (41 percent) of the title compound as a tan foam. LC/MS: Rt = 4.43. MS (ESI): mass calcd. for C22H29N3O2S, 399.56; m/z found, 400.2 [M+H]+. 1H NMR (CDCI3): 7.87 (d, J = 8.3, 1 H), 7.86 (s, 1 H), 7.57 (s, 1 H), 7.38 (d, J = 8.3, 1 H), 3.79 (br s, 4H), 3.59 (br s, 2H), 3.55 (br s, 2H), 2.71 (h, J = 6.5, 1 H), 2.58 (br s, 2H), 2.42 (br s, 2H), 1.66 (br s, 4H), 1.56 (br s, 2H), 1.02 (d, J = 6.5, 6H).

4318-42-7 1-Isopropylpiperazine 78013, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; JANSSEN PHARMACEUTICA N.V.; WO2008/109333; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4318-42-7,1-Isopropylpiperazine,as a common compound, the synthetic route is as follows.

Intermediate B58: 4-[4-(1 -methylethyl)-1 -piperazinyl]-2,5-bis(methyloxy)aniline; Step A/Intermediate B59: 1-[2,5-bis(methyloxy)-4-nitrophenyl]-4-(1- methylethyl)piperazine; 1-chloro-2,5-bis(methyloxy)-4-nitrobenzene (3.25g, 15 mmol, TCI America), isopropylpiperizine (3.84g, 30 mmol, Oakwood Products), cesium carbonate (9.8g, 30 mmol), Pd2dba3 (1.37g, 1.5 mmol), and XANTPHOS (1.3g, 2.25 mmol) were added to degassed dioxane (80 mL) and heated to 1000C under a water cooled reflux condenser for 12 hours. The dioxane was removed under reduced pressure and the solids were partitioned between methylene chloride (500 mL) and water (500 mL). The organic layer was dried over sodium sulfate, taken to a residue under reduced pressure, and purified by chromatography on SiO2 to give 1-[2,5- bis(methyloxy)-4-nitrophenyl]-4-(1-methylethyl)piperazine as a yellow solid (3.5g, 11.3 mmol, 76percent yield). 1 H NMR (400 MHz, CDCI3) delta ppm 1.09 (d, J=6.60 Hz, 6 H), 2.69 – 2.73 (m, 4 H), 2.75 (d, J=6.60 Hz, 1 H), 3.23 – 3.32 (m, 4 H), 3.88 (s, 3 H), 3.94 (s, 3 H), 6.48 (s, 1 H), 7.55 (s, 1 H)., 4318-42-7

The synthetic route of 4318-42-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2009/20990; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

4318-42-7, 1-Isopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4318-42-7

(1H-Indol-5-yl)-(4-isopropyl-piperazin-1-yl)-methanone A mixture of 3.23 g (20 mmol) indole-5-caboxylic acid (commercially available), 3.07 g (24 mmol) 1-(2-propyl)-piperazine (commercially available), 8.03 g (25 mmol) TBTU and 10.3 mL (60 mmol) DIPEA in 50 mL DMF was stirred for 2 h (hours) at room temperature. After evaporation of all volatiles the residue was extracted with ethyl acetate, the combined organic layers dried with MgSO4 and evaporated to dryness. The residue was subsequently purified by flash column chromatography eluding with a mixture formed from DCM, MeOH, and NH3 aq. to yield after evaporation of the combined product fractions 5.1 g (94percent) of the title compound as light brown foam. MS(m/e): 272.3 (MH+).

The synthetic route of 4318-42-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nettekoven, Matthias Heinrich; Roche, Olivier; US2007/270423; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics