Category: 4318-42-7

4318-42-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4318-42-7,1-Isopropylpiperazine,as a common compound, the synthetic route is as follows.

Example 75 N-{2- [3 -Fluoro-5- (4-isopropyl-piperazin- 1 -yl) -phenyl] -3 ,3 -dimethyl- 1 ,2,3 ,4- tetrahydro-quinoline-6-carbonyl}-methanesulfonamideA mixture of 2-(3-bromo-5-fiuoro-phenyl)-3,3-dimethyl-l,2,3,4-tetrahydro-quinoline-6- carboxylic acid methyl ester (0.41 g, 1.0 mmol), 1-isopropyl piperazine (0.64 g, 5.0 mmol), copper (I) iodidie (120 mg, 0.6 mmol), L-proline (69 mg, 0.6 mmol) and potassium hydroxide (33.6 mg, 0.6 mmol) in DMSO (2 mL) was stirred at 120 ¡ãC for 2 hours. Then treated with saturated ammonium chloride (20 mL), extracted with ether (100 mL). After removal of solvent, the residue was purified on flash silica gel chromatography (silica gel from QingDao, 200-300 mesh, glass column from Shanghai SD company)(40percent ethyl acetate/hexanes) to afford 2-[3-fiuoro-5-(4-isopropyl-piperazin-l-yl)-phenyl] -3,3- dimethyl-l,2,3,4-tetrahydro-quinoline-6-carboxylic acid ethyl ester (0.27 g, 60percent) as a white solid: LC/MS m/e calcd for C27H36FN3O2 (M+H)+: 454.6, observed: 454.3.

As the paragraph descriping shows that 4318-42-7 is playing an increasingly important role.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; CHEN, Li; FENG, Lichun; HUANG, Mengwei; LIU, Yongfu; WU, Guolong; WU, Jim, Zhen; ZHOU, Mingwei; WO2011/128251; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4318-42-7,1-Isopropylpiperazine,as a common compound, the synthetic route is as follows.

Step I: (4-bromophenyl)-(4-isopropylpiperazin-1-yl)methanone (1-13) To a stirred solution of 4-bromobenzoic acid 1-12 at 0¡ã C. (2 g, 9.94 mmol) in a mixture of MeCN:DMF (4:1, 20 mL) were added HATU (4.53 g, 11.93 mmol) and 1-isopropylpiperazine (1.91 g, 14.92 mmol). The reaction mixture was allowed to stir for 30 minutes, and then diisopropylethylamine (3.85 g, 5.2 mL, 29.84 mmol) was added thereto. The resulting reaction mixture was stirred for 16 hours at room temperature. After completion of reaction, the reaction mixture was diluted with water and extracted with ethyl acetate (25 mL*3). The combined organic layer was washed with water and brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The obtained residue was purified by silica gel (60-120 mesh size) column chromatography using 0-5percent methanol in dichloromethane as eluent to give the desired product 1-13 (3.0 g, 97percent) as brown solid; LCMS: m/z 312.00 (M++1)., 4318-42-7

The synthetic route of 4318-42-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; KOUL, Summon; KURHADE, Suresh; BHOSALE, Sandeep; NAIK, Keshav; SALUNKHE, Videsh; MUNOT, Yogesh; BHUNIYA, Debnath; (132 pag.)US2017/8885; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

4318-42-7, 1-Isopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step A: r5-(4-lsopropyl-piperazin-1 -yl)-2-(4-methylsulfanyl-phenoxy)- benzyli-methyl-carbamic acid tert-butyl ester.; A mixture of [5-bromo-2-(4- methylsulfanyl-phenoxy)-benzyl]-methyl-carbamic acid tert-butyl ester (300 mg, 0.684 mmol) {prepared in an analogous fashion to Example 1 , Steps A-C}, isopropyl piperazine (132 mg, 1.02 mmol), XPHOS (39 mg, 0.082 mmol), Pd2(dba)3 (62.6 mg, 0.0684 mmol), and t-BuONa (98.0 mg, 1.02 mmol) in toluene was heated in a sealed tube overnight at 120 0C. After cooling to rt, the mixture was filtered through diatomaceous earth and the filtrate was concentrated. Purification by FCC gave the desired product (180 mg, 54percent). MS (ESI): mass calcd. for C27H39N3O3S, 485.27; m/z found, 486.4 [M+H]+. 1H NMR (CDCI3): 7.22 (d, J = 8.5, 2H), 6.86-6.83 (m, 1 H), 6.83-6.80 (m, 4H), 4.42- 4.35 (m, 2H), 3.19-3.16 (m, 4H), 2.87-2.83 (m, 2H), 2.80-2.75 (m, 1 H), 2.75- 2.71 (m, 1 H), 2.71-2.67 (m, 4H), 2.44 (s, 3H), 1.48-1.40 (m, 9H), 1.10 (d, J = 6.5, 6H).

4318-42-7, 4318-42-7 1-Isopropylpiperazine 78013, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; JANSSEN PHARMACEUTICA N.V.; WO2008/2820; (2008); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

4318-42-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4318-42-7,1-Isopropylpiperazine,as a common compound, the synthetic route is as follows.

In N2 Under protection, three-necked flask with stirring and the funnel was added dropwise and THF150ml 100mmol isopropyl piperazine, in an ice bath, was slowly added dropwise through a dropping funnel 100mmol butyllithium dropwise after l to room temperature, the reaction after 1h.Under a 71/92 then cooled to 0¡ãC 100mmol cyclohexyl trimethoxysilane, after the completion of the dropwise addition the reaction at room temperature for 8h, and finally through G4Funnel, the solid residue was washed repeatedly with tetrahydrofuran and filtered, the filtrate was collected.With a rotary evaporator to tetrahydrofuran solvent, vacuum distillation, collecting 136 ~ 139¡ãC / 100pa fraction.Vacuum distillation, collecting 136 ~ 139¡ãC/ 100pa distillate, heavy 5.3g, 98.2percent yield,

As the paragraph descriping shows that 4318-42-7 is playing an increasingly important role.

Reference£º
Patent; Institute of Chemistry Chinese Academy of Sciences; Li, Huayi; Chang, Hefei; Zhang, Liaoyun; Hu, Youliang; (19 pag.)CN102977133; (2016); B;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

4318-42-7, 1-Isopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 2 (General procedure A); 2-(4-lsopropylpiperazin-1-yl)-6-methoxybenzothiazole, hydrochloride; A mixture of 2-chloro-6-methoxybenzothiazole (0.20 g, 1.0 mmol) and 1-isopropylpiperazine (0.26 g, 2.0 mmol) was stirred at 120 0C for 2 h. The reaction mixture was allowed to cool and worked up by extraction with ethyl acetate. The organic extract was washed with a Na- HCO3 solution and water (3 x). The organic phase was extracted with 0.25 M hydrochloric acid (10 ml_). The acidic aqueous extract was concentrated and re-evaporated with ethanol. The residue was crystallized from a mixture of ethanol and ethyl acetate to give 260 mg (80 percent) of 2-(4-isopropylpiperazin-1-yl)-6-methoxybenzothiazole, hydrochloride. 1H-NMR (400MHz, DMSO-d6) delta 11.7 (brs, 1 H), 7.52 (d, 1 H), 7.49 (d, 1 H), 6.97 (dd, 1 H), 4.23-4.15 (m, 2H), 3.88-3.75 (m, 5H), 3.55-3.47 (m, 3H), 3.28-3.15 (m, 2H), 1.32 (d, 6H).

4318-42-7, The synthetic route of 4318-42-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVO NORDISK A/S; WO2007/110364; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

4318-42-7, 1-Isopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4318-42-7

N, N -CARBONYLDIIMIDAZOLE (11. 0G, 67.5 mmol) was added to a solution of D8 (14.9 g, 32.2 mmol) in DMAC (100 mL) at room temp. Vigorous gas evolution was evident. The reaction mixture was stirred for 1 hour forming a yellow ppt after 15 min. Additional DMAC (50 mL) was added to aid stirring. i-Propylpiperazine (9.5 g, 74.0 mmol) was added and the reaction mixture became homogeneous. The reaction mixture was stirred overnight, forming a yellow ppt, then poured into H20 (1000 mL). The solid was collected by filtration, suspended in ETOH (300 mL) and heated to boiling. After cooling slightly, the solid was collected by filtration, rinsed with ETOH (50 mL), then Et2O (100 mL), and dried under vacuum to give D9 (17.4 g, 94 percent yield) as a yellow solid.

4318-42-7 1-Isopropylpiperazine 78013, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; GPC BIOTECH, INC.; WO2004/92139; (2004); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4318-42-7,1-Isopropylpiperazine,as a common compound, the synthetic route is as follows.

To a solution of 2-chloro-5-nitropyridine (2.5g, 15.7mmol) in THF (25mL), are added1 -isopropylpiperazine (2.01g, 15.7mmol) and K2CO3 (3.25g, 23.6mmol). The reaction mixture is stirred at 5O0C for 4 hours and then at 7O0C overnight. The solvent is removed in vacuo and the resultant orange solid is triturated using 10:1 petroleum ether-diethyl ether. The isolated compound (3.7g, 94percent) is used in the next step without further purification.

4318-42-7, As the paragraph descriping shows that 4318-42-7 is playing an increasingly important role.

Reference£º
Patent; GALAPAGOS N.V.; WO2007/138072; (2007); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

4318-42-7, 1-Isopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1To 5-bromo-2-nitropyridine (1.0 g, 4.93 mmol, Eq: 1.00) in DMSO (10.0 ml) was added 1-isopropylpiperazine (632 mg, 4.93 mmol, Eq: 1.00), and the resulting solution was heated at 70¡ã C. for 18 hours.The solution was cooled to room temperature.The solution was diluted with 50 ml water.The resulting solid was filtered.The solid was washed with water and dried under vacuum.The crude material was purified by flash chromatography (silica gel, 80 g, 0percent to 3percent MeOH/DCM gradient) to give 1-isopropyl-4-(6-nitropyridin-3-yl)piperazine (788 mg, 64percent). LC/MS-ESI observed [M+H]+ 251.

4318-42-7, The synthetic route of 4318-42-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Berthel, Steven Joseph; Billedeau, Roland Joseph; Brotherton-Pleiss, Christine E.; Firooznia, Fariborz; Gabriel, Stephen Deems; Han, Xiaochun; Hilgenkamp, Ramona; Jaime-Figueroa, Saul; Kocer, Buelent; Lopez-Tapia, Francisco Javier; Lou, Yan; Orzechowski, Lucja; Owens, Timothy D.; Tan, Jenny; Wovkulich, Peter Michael; US2012/40949; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4318-42-7,1-Isopropylpiperazine,as a common compound, the synthetic route is as follows.

0Example 1 4- [6- (4-ISOPROPYLPIPERAZIN-1-YL)-PYRIDAZIN-3-YL] BENZONITRILE A suspension OF 4- (6-CHLORO-PYRIDAZIN-3-YL)-BENZONITRILE (1 g, 4.64 mmol ; prepared as de- scribed in US patent No. 4,112, 095), isopropylpiperazine (0.654 g, 5.1 MMOL), DIPEA (1.199 g, 9.27 MMOL) and 4- (DIMETHYLAMINO) PYRIDINE (0.057g, 0.464 MMOL) in DMSO (4 mi) was stirred and heated to 100 ¡ãC for 20h. After cooling to room temperature, the mixture was di- luted with DICHLOROMETHANE (25 ml) and water (35 ml) and stirred for 5 min. The organic phase was separated, washed with water (50 ml) and brine (50 ML), and acidified to pH 2 by addition of 1 N hydrochloric acid. The mixture was extracted with water (30 ML), and the aque- ous phase was washed with DICHLOROMETHANE (10 mi) and concentrated in vacuo to give a solid, which was collected and stripped with ethanol to afford the title compound as a crys- talline hydrochloride (1.33 g, 76percent). ‘H NMR (D2O) 51. 30 (d, 6H), 3.26 (broad t, 2H), 3.45-3. 68 (m, 5H), 4.52 (broad d, 2H), 7.75 (d, 1H), 7.77 (d, 2H), 7.87 (d, 2H), 8.12 (d, 1H) ; HPLC-MS: M/Z 308.2 (MH+) ; Rt : 1.76 min., 4318-42-7

The synthetic route of 4318-42-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVO NORDISK A/S; WO2005/9976; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4318-42-7,1-Isopropylpiperazine,as a common compound, the synthetic route is as follows.

Step 1 l-Isopropyl-4-(4-niotatro-phenyl)-piotaperaziotane[00393] To a solution of 4-fluoromtrobenzene (5g, 35 4mmol) m THF (5OmL), 1- lsopropylpiperazme (4 54g, 35 4mmol) and K2CO3 (7 35g, 53 2mmol) are added The reaction mixture is stirred at room temperature overnight The solvent is removed in vacuo and the residue is partitioned between EtOAc and water The organic layer is washed with brine, dpied over MgSO4, filtered and concentrated The crude compound is purified by silica gel column chromatography using 99 1 and 98 2 DCM NH3 (7M in MeOH) to give the title compound (8 2g, 94percent)

4318-42-7, 4318-42-7 1-Isopropylpiperazine 78013, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; GALAPAGOS N.V.; WO2007/131991; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics