Category: 412293-98-2

In ,Physical Chemistry Chemical Physics included an article by Sauter, Eric; Nascimbeni, Giulia; Trefz, Daniel; Ludwigs, Sabine; Zojer, Egbert; von Wrochem, Florian; Zharnikov, Michael. Recommanded Product: 412293-98-2. The article was titled 《A dithiocarbamate anchoring group as a flexible platform for interface engineering》. The information in the text is summarized as follows:

The mol. organization and electronic properties of dithiocarbamate (DTC) anchored self-assembled monolayers (SAMs) linked to Au(111) substrates are studied by a combination of XPS, near-edge X-ray absorption fine structure (NEXAFS) spectroscopy, and state-of-the-art d. functional theory calculations For that, several piperidine/piperazine precursors with different architecture and substitution patterns are selected. The presented data show that the DTC anchor provides a useful building block for monomol. self-assembly on coinage metals with both sulfur atoms bonded to the substrate in a way similar to what is usually observed for the more commonly applied thiolate docking group. The combination of the DTC group with the quite flexible piperidine/piperazine cyclic linkers results in a dense mol. packing with an upright orientation of the terminal moieties. The latter comprise Ph rings bearing various substituents, which enables tuning the interfacial dipole over a wide range. Simulations on two prototypical DTC-docked SAMs help to better understand the exptl. observations and provide insight into the local origin of the SAM-induced shifts in the electrostatic energy. In particular, a comparison of measured and simulated XP spectra reveals the significant contribution of the DTC group to the interfacial dipole. In the experiment, the researchers used 1-(Phenylsulfonyl)piperazine hydrochloride(cas: 412293-98-2Recommanded Product: 412293-98-2)

1-(Phenylsulfonyl)piperazine hydrochloride(cas: 412293-98-2) belongs to piperazines. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Recommanded Product: 412293-98-2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

《A Simplified Protocol for Routine Chemoselective Syntheses of Piperazines Substituted in the 1-Position by an Electron Withdrawing Group》 was written by Nemeckova-Herova, Dana; Pazdera, Pavel. Electric Literature of C10H15ClN2O2S And the article was included in Current Organic Synthesis on April 30 ,2015. The article conveys some information:

A simplified protocol for the routine direct chemoselective preparation of various piperazines substituted in the 1-position by an electron withdrawing group were reported. These synthesis were based on the reaction of piperazine-1-ium cation with different electrophilic reagents, such as acyl chlorides, anhydrides, sulfonyl chlorides, carbamoyl chlorides, and nitrourea as well. Piperazine-1-ium cation was chosen because the reactions of piperazine with electrophilic reagents in different solvents at usual temperatures were not chemoselective and provide mixtures, e.g., I, comprising 1-substituted, 1,4-disubstituted and unsubstituted piperazine as well. It was found that for in situ generating of starting piperazine-1-ium cation from piperazine the application of acetic acid as reaction medium or the chemisorption of piperazine on weakly acidic cation exchanger resin were highly acceptable in terms of both reaction times and yields. The usage of resin supported piperazine-1-ium cation in reaction with carboxylic anhydrides or nitrourea is an example of the solid phase synthesis with ionically bonded substrate. Furthermore, synthesis in acetic acid medium were effectively catalyzed by Cu+, Cu2+ or Al3+ ions supported on weakly acidic cation-exchanger resin as well. Finally, it was observed that application of the solid support metal catalysis afforded target products in shortened reaction times and in 82-95% yields. The experimental part of the paper was very detailed, including the reaction process of 1-(Phenylsulfonyl)piperazine hydrochloride(cas: 412293-98-2Electric Literature of C10H15ClN2O2S)

1-(Phenylsulfonyl)piperazine hydrochloride(cas: 412293-98-2) belongs to piperazines. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Electric Literature of C10H15ClN2O2S

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

《A Simplified Protocol for Routine Chemoselective Syntheses of Piperazines Substituted in the 1-Position by an Electron Withdrawing Group》 was written by Nemeckova-Herova, Dana; Pazdera, Pavel. Electric Literature of C10H15ClN2O2S And the article was included in Current Organic Synthesis on April 30 ,2015. The article conveys some information:

A simplified protocol for the routine direct chemoselective preparation of various piperazines substituted in the 1-position by an electron withdrawing group were reported. These synthesis were based on the reaction of piperazine-1-ium cation with different electrophilic reagents, such as acyl chlorides, anhydrides, sulfonyl chlorides, carbamoyl chlorides, and nitrourea as well. Piperazine-1-ium cation was chosen because the reactions of piperazine with electrophilic reagents in different solvents at usual temperatures were not chemoselective and provide mixtures, e.g., I, comprising 1-substituted, 1,4-disubstituted and unsubstituted piperazine as well. It was found that for in situ generating of starting piperazine-1-ium cation from piperazine the application of acetic acid as reaction medium or the chemisorption of piperazine on weakly acidic cation exchanger resin were highly acceptable in terms of both reaction times and yields. The usage of resin supported piperazine-1-ium cation in reaction with carboxylic anhydrides or nitrourea is an example of the solid phase synthesis with ionically bonded substrate. Furthermore, synthesis in acetic acid medium were effectively catalyzed by Cu+, Cu2+ or Al3+ ions supported on weakly acidic cation-exchanger resin as well. Finally, it was observed that application of the solid support metal catalysis afforded target products in shortened reaction times and in 82-95% yields. The experimental part of the paper was very detailed, including the reaction process of 1-(Phenylsulfonyl)piperazine hydrochloride(cas: 412293-98-2Electric Literature of C10H15ClN2O2S)

1-(Phenylsulfonyl)piperazine hydrochloride(cas: 412293-98-2) belongs to piperazines. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Electric Literature of C10H15ClN2O2S

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics