393781-70-9, (R)-1-Boc-2-Ethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
The 3 – ((2,4-dioxo -3,4-dihydrochinazolines having antiviral properties -1 (2H)-yl) methyl) benzoic acid (250 mg, 0 . 80mmol), EDC (307 mg, 1 . 6mmol), HOBT (217 mg, 1 . 6mmol) and DIEA (162 mg, 1 . 60mmol) into the reaction bottle in, addition of about 3 ml of the dissolution of water-free DMF, r.t. The lower stirring 15 min, then dropwise (R)-N-Boc-2-ethyl piperazine (258 mg, 1 . 20mmol) in the DMF solution to the reaction solution, r.t. The lower stirring overnight, the reaction solution is poured into 100 ml water, using 100mLDCM extraction, an organic layer for sequentially 1MHCl (100 ml), saturated NaCl (100 ml) and water (100 ml) washing, vacuum concentration, silica gel column chromatography, to obtain 236 mg solid, yield 58.1%., 393781-70-9
The synthetic route of 393781-70-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Institute Of Materia Medica Chinese Academy Of Medical Sciences; Xu, Bailing; Chen, Xiaoguang; Yao, Haiping; Ji, Ming; Jin, Jing; Zhou, Jie; Wang, Ke; Zhao, Dalong; (55 pag.)CN105461697; (2016); A;,
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