Category: 393781-70-9

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.393781-70-9,(R)-1-Boc-2-Ethylpiperazine,as a common compound, the synthetic route is as follows.,393781-70-9

The original compound 82a is4-chloro-N- (1-methyl-1H-pyrazol-4-yl) pyrimidin-2-amine (627 mg, 3.00 mmol)And N, N-dimethylformamide (20 mL)Into a single-mouth bottle,Then compound 90b is(R) -2-Ethylpiperazine-1-carboxylic acid tert-butyl ester(632mg, 3.0mmol)And cesium carbonate (1.95g, 6.0mmol)Into a single-mouth bottle,The reaction was carried out at 90 C for 16 hours.Add the reaction solution after washingEthyl acetate extraction (100mL * 3),Combined organic phases,After washing with water and saturated saline,Dry and concentrated,Purification by column (ethyl acetate / methanol = 20/1) gave compound 90c as a pale yellow solid, namely(R) -2-ethyl-4- (2-((1-methyl-1H-pyrazol-4-yl) amino) pyrimidine-4-yl) piperazine-1-carboxylic acid tert-butyl ester(740 mg, 55% yield).

The synthetic route of 393781-70-9 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Jiaxing Tekeluo Biological Technology Co., Ltd.; Xing Li; Li Guanqun; Wang Xiaolei; Cai Yuting; Jiang Xiang; Pan Xiang; Zhu Wenhao; Wang Yang; Wang Zengquan; (51 pag.)CN110862376; (2020); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.393781-70-9,(R)-1-Boc-2-Ethylpiperazine,as a common compound, the synthetic route is as follows.,393781-70-9

The original compound 82a is4-chloro-N- (1-methyl-1H-pyrazol-4-yl) pyrimidin-2-amine (627 mg, 3.00 mmol)And N, N-dimethylformamide (20 mL)Into a single-mouth bottle,Then compound 90b is(R) -2-Ethylpiperazine-1-carboxylic acid tert-butyl ester(632mg, 3.0mmol)And cesium carbonate (1.95g, 6.0mmol)Into a single-mouth bottle,The reaction was carried out at 90 C for 16 hours.Add the reaction solution after washingEthyl acetate extraction (100mL * 3),Combined organic phases,After washing with water and saturated saline,Dry and concentrated,Purification by column (ethyl acetate / methanol = 20/1) gave compound 90c as a pale yellow solid, namely(R) -2-ethyl-4- (2-((1-methyl-1H-pyrazol-4-yl) amino) pyrimidine-4-yl) piperazine-1-carboxylic acid tert-butyl ester(740 mg, 55% yield).

The synthetic route of 393781-70-9 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Jiaxing Tekeluo Biological Technology Co., Ltd.; Xing Li; Li Guanqun; Wang Xiaolei; Cai Yuting; Jiang Xiang; Pan Xiang; Zhu Wenhao; Wang Yang; Wang Zengquan; (51 pag.)CN110862376; (2020); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.393781-70-9,(R)-1-Boc-2-Ethylpiperazine,as a common compound, the synthetic route is as follows.

Step A: To a solution of (R)-tert-butyl 2-ethylpiperazine-l-carboxylate (0.208 g, 0.971 mmol, Eq: 1.00) and triethylamine (0.135 ml, 0.971 mmol, Eq: 1.00) in DMF (2ml) was added methyl 2,6- dichloronicotinate (0.200 g, 0.971 mmol, Eq: 1.00) and the reaction mixture stirred at 30C for 4.5 hrs. The reaction mixture was diluted with EtOAc and washed with water and brine, the organic phase was dried over Na2S04 and the solvent evaporated. The crude was purified by column chromatography (Si02, EtOAc/Heptane, 1/4) to give 160 mg (43%) of tert-butyl (2R)-4- (6-chloro-5-methoxycarbonyl-2-pyridyl)-2-ethyl-piperazine-l-carboxylate as a white solid. MS (m/e): 384.2 (M+H+)., 393781-70-9

As the paragraph descriping shows that 393781-70-9 is playing an increasingly important role.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GREEN, Luke; PINARD, Emmanuel; RATNI, Hasane; WILLIAMSON, Patrick; (95 pag.)WO2015/197503; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

393781-70-9, (R)-1-Boc-2-Ethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of (R)-2-ethylpiperazine-1-carboxylic acid tert-butyl ester (1 g) and 3,5-dimethylpyridine-N-oxide (546 mg)in tetrahydrofuran (18 mL) were added N,N-diisopropylethylamine (3 mL) and bromotris(pyrrolidino)phosphonium hexafluorophosphate (2.8 g) and the mixture was stirred at room temperature overnight. Water was added to the reaction mixture,and the mixture was extracted with ethyl acetate and chloroform. The solvent was evaporated and the obtained residue was purified by column chromatography (ethyl acetate:hexane)to give (R)-4-(3,5-dimethylpyridin-2-yl)-2-ethylpiperazine-1-carboxylic acid tert-butyl ester (1.11 g)., 393781-70-9

As the paragraph descriping shows that 393781-70-9 is playing an increasingly important role.

Reference£º
Patent; Mitsubishi Tanabe Pharma Corporation; ISHIBUCHI, Seigo; SARUTA, Kunio; HAMADA, Maiko; MATOBA, Nobuatsu; MATSUDAIRA, Tetsuji; SEKI, Maki; TARAO, Akiko; HONJO, Takashi; OGATA, Shingo; KAWATA, Atsushi; MOROKUMA, Kenji; FUJIE, Naoto; AOYAMA, Yukio; (251 pag.)EP3321256; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics