Category: 38216-72-7

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.38216-72-7,1-tert-Butylpiperazine,as a common compound, the synthetic route is as follows.

A. Synthesis of l-(4-(4-fert-butylpiperazin-l-yl)(phenyl)methyl)piperidin-l-yl)ethanone; [0092] 1-tert-butylpiperazine (4.48 g, 20.8 mmol), l-(4-(chloro(phenyl)methyl)piperidin-l-yl)ethanone (5.77 g, 22.9 mmol), K2CO3 (7.2 g, 52.1 mmol), and KI (22.9 mmol) were combined in dry DMF (150 mL). The reaction was refluxed overnight. Upon completion of the reaction, the DMF was removed under reduced pressure. The resulting crude was taken up in water (75 mL) and washed with EtOAc (3 x 100 mL). The organic portions were combined, dried (Na2SO4) and concentrated. The product was purified by silica gel chromatography (2.5:2.5:95 Et3N/MeOH/EtOAc, Rf 0.4) and isolated as a red oil (2.66 g, 36%).

38216-72-7, 38216-72-7 1-tert-Butylpiperazine 3530572, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; NEUROMED PHARMACEUTICALS LTD.; WO2008/31227; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

38216-72-7, 1-tert-Butylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

INTERMEDIATE 5 [TERT-BUTYL 4-(6-BROMOQUINOLIN-4-YL) PIPERAZINE-1-CARBOXYLATE] [6-BROMO-4-CHLOROQUINOLINE] (5.0 g, 20.6 mmol), [TERT-BUTYL-L-PIPERAZINE] (4.1 g, 22 mmol), triethylamine (3 mL, 22 mmol) and DMSO (20 [ML)] were mixed and heated overnight in an oil bath at [100C.] The reaction was cooled and diluted with diethyl ether and washed with water [(5X),] dried [(MGS04)] and evaporated. The residue was filtered through a short column of silica (2.5-5 %) MeOH in CH2C12 and evaporated. Yield 8.02 g. (97 %). Brown liquid. HPLC 98 %, [RT=3.] 01 (System [AL,] 10-97 % [MECN] over 3 [MIN). 1H] NMR (400 MHz, [CDC13)] 8 ppm 1.52 (s, 9 H) 3.12-3. 17 (m, 4 H) 3.69-3. 75 (m, 4 H) 6.86 (d, [J=5.] 0 Hz, 1 H) 7.72 [(DD,] [J=9.] 0,2. 26 Hz, 1 H) 7.92 [(D,] [J=8.] 8 Hz, 1 H) 8.14 (d, [J=2.] 3 Hz, 1 H) 8.73 (d, J=5.0 Hz, 1 H). MS (ESI+) for [C18H22BRN302] m/z 392.2 (M+H+)

38216-72-7, As the paragraph descriping shows that 38216-72-7 is playing an increasingly important role.

Reference：
Patent; BIOVITRUM AB; WO2004/828; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

38216-72-7, 1-tert-Butylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

INTERMEDIATE 5 [TERT-BUTYL 4-(6-BROMOQUINOLIN-4-YL) PIPERAZINE-1-CARBOXYLATE] [6-BROMO-4-CHLOROQUINOLINE] (5.0 g, 20.6 mmol), [TERT-BUTYL-L-PIPERAZINE] (4.1 g, 22 mmol), triethylamine (3 mL, 22 mmol) and DMSO (20 [ML)] were mixed and heated overnight in an oil bath at [100C.] The reaction was cooled and diluted with diethyl ether and washed with water [(5X),] dried [(MGS04)] and evaporated. The residue was filtered through a short column of silica (2.5-5 %) MeOH in CH2C12 and evaporated. Yield 8.02 g. (97 %). Brown liquid. HPLC 98 %, [RT=3.] 01 (System [AL,] 10-97 % [MECN] over 3 [MIN). 1H] NMR (400 MHz, [CDC13)] 8 ppm 1.52 (s, 9 H) 3.12-3. 17 (m, 4 H) 3.69-3. 75 (m, 4 H) 6.86 (d, [J=5.] 0 Hz, 1 H) 7.72 [(DD,] [J=9.] 0,2. 26 Hz, 1 H) 7.92 [(D,] [J=8.] 8 Hz, 1 H) 8.14 (d, [J=2.] 3 Hz, 1 H) 8.73 (d, J=5.0 Hz, 1 H). MS (ESI+) for [C18H22BRN302] m/z 392.2 (M+H+)

38216-72-7, As the paragraph descriping shows that 38216-72-7 is playing an increasingly important role.

Reference：
Patent; BIOVITRUM AB; WO2004/828; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

38216-72-7, 1-tert-Butylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of l-fluoro-4-nitro-benzene (314mg, 2.23mmol) and 4-tert-butyl- piperazine (Ig, 3.34mmol) in dioxane (15mL) is added K2CO3 (1.65mg, 11.9mmol) and the reaction is stirred at 13O0C overnight. The solvent is evaporated under vacuum and the residue is partitioned between ethyl acetate and water. The organic layer is washed with brine, dried over MgSO4, filtered and concentrated to give a crude compound. Purification by silica gel column chromatography eluting with DCM followed by 99:1 DCM:NH3 (7M in MeOH) affords the title compound (348mg, 55.4%). LCMS: Rt 3.87min (99%)., 38216-72-7

The synthetic route of 38216-72-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; GALAPAGOS N.V.; WO2007/138072; (2007); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.38216-72-7,1-tert-Butylpiperazine,as a common compound, the synthetic route is as follows.

A. Synthesis of l-(4-(4-fert-butylpiperazin-l-yl)(phenyl)methyl)piperidin-l-yl)ethanone; [0092] 1-tert-butylpiperazine (4.48 g, 20.8 mmol), l-(4-(chloro(phenyl)methyl)piperidin-l-yl)ethanone (5.77 g, 22.9 mmol), K2CO3 (7.2 g, 52.1 mmol), and KI (22.9 mmol) were combined in dry DMF (150 mL). The reaction was refluxed overnight. Upon completion of the reaction, the DMF was removed under reduced pressure. The resulting crude was taken up in water (75 mL) and washed with EtOAc (3 x 100 mL). The organic portions were combined, dried (Na2SO4) and concentrated. The product was purified by silica gel chromatography (2.5:2.5:95 Et3N/MeOH/EtOAc, Rf 0.4) and isolated as a red oil (2.66 g, 36%).

38216-72-7, 38216-72-7 1-tert-Butylpiperazine 3530572, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; NEUROMED PHARMACEUTICALS LTD.; WO2008/31227; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics