Category: 34770-60-0piperazines

34770-60-0, 4-Methylpiperazin-2-one is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0209] Step 1. To a solution of N-(l-(lH-indol-3-yl)hexan-2-yl)-2-bromothiazole-5- carboxamide (0.10 g, 0.24 mmol) and 4-methylpiperazin-2-one (0.03 g, 0.29 mmol) in dioxane (7 mL), Cs2C03 (0.23 g, 0.72 mmol) and 2-(dicyclohexylphosphino)3,6-dimethoxy-2′,4′,6′- triisopropyl-l,l’-biphenyl (BrettPhos precatalyst; 0.02 g, 0.02 mmol) were added. The reaction vessel was purged with argon for 20 min and the mixture was then heated at 110 C for 16 h. The reaction mixture was filtered through diatomaceous earth, washing with 5% MeOH in DCM (2 x 10 mL). The filtrate was concentrated, and the crude obtained was purified by column chromatography (silica, 100-200 mesh, 1 to 4% MeOH in DCM) and preparative HPLC to afford the title compound (0.03 g, 14%) as a white solid. HPLC Purity: 99.4%; MS (ESI) m/e [M+H]+/Rt/%: 440.00/2.69/98.0%; 1H NMR (400 MHz, DMSO-d6) delta 0.81 (t, 7 = 6.8 Hz, 3H), 1.19-1.35 (m, 4H), 1.47-1.63 (m, 2H), 2.31 (s, 3H), 2.81 (t, 7 = 5.4 Hz, 2H), 2.85-2.97 (m, 2H), 3.34 (s, 2H), 4.03 (t, 7 = 5.6 Hz, 2H), 4.16 (m, 1H), 6.92-6.98 (m, 1H), 7.04 (t, 7 = 7.6 Hz, 1H), 7.11 (d, 7 = 1.5 Hz, 1H), 7.31 (d, 7 = 8.3 Hz, 1H), 7.58 (d, 7 = 7.8 Hz, 1H), 8.13 (s, 1H), 8.24 (d, 7 = 8.8 Hz, 1H), 10.75 (brs, 1H).

34770-60-0, The synthetic route of 34770-60-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NEUROPORE THERAPIES, INC.; WRASIDLO, Wolfgang; STOCKING, Emily, M.; HALL, Adrian; MACCOSS, Malcolm; (139 pag.)WO2017/20010; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34770-60-0,4-Methylpiperazin-2-one,as a common compound, the synthetic route is as follows.

General procedure: A mixture of aryl bromide (1.0 mmol), 4-methylpiperazin-2-one (for compounds 15-17)/morpholin-3-one (for compounds 18-20) (2.0 mmol), N,N0-dimethylethylene diamine (0.1 mmol), K2CO3 (2.0 mmol) and CuI (0.05 mmol) in anhydrous toluene was heated to reflux with stirring for 6 h. Then the reaction mixture was cooled to room temperature, poured into water, stirred vigorously and extracted thrice with ethyl acetate, dried over anhydrous Na2SO4, concentrated under reduced pressure and purified by flash chromatography to afford compounds 14a-f in 54-68% yields. 6.1.16 4-Methyl-1-(4-vinylphenyl)piperazin-2-one (14a) A mixture of 1-bromo-4-vinylbenzene 9 (1.0 g, 5.46 mmol), 4-methylpiperazin-2-one (1.24 g, 10.93 mmol), N,N’-dimethylethylene diamine (0.04 g, 0.54 mmol), K2CO3 (1.51 g, 10.93 mmol) and CuI (0.05 g, 0.27 mmol) in anhydrous toluene was heated to reflux and the reaction was continued as described in general procedure IV to afford 14a (0.7 g) in 60% yield. 1H NMR (400 MHz, CDCl3): delta 7.39-7.48 (m, 2H), 7.24-7.27 (m, 2H), 6.70 (dd, J = 17.6, 10.9 Hz, 1H), 5.73 (dt, J = 17.6, 0.9 Hz, 1H), 5.26 (dt, J = 10.9, 0.9 Hz, 1H), 3.65-3.75 (m, 2H), 3.28 (s, 2H), 2.75-2.83 (m, 2H), 2.41 (s, 3H); LC-MS: 217 (M++1)., 34770-60-0

As the paragraph descriping shows that 34770-60-0 is playing an increasingly important role.

Reference£º
Article; Rakesh; Bruhn, David; Maddox, Marcus; Lee, Robin B.; Yang, Lei; Lee, Richard E.; Madhura, Dora B.; Trivedi, Ashit; Meibohm, Bernd; Scherman, Michael S.; Gilliland, Janet C.; Gruppo, Veronica; McNeil, Michael R.; Lenaerts, Anne J.; Bioorganic and medicinal chemistry; vol. 20; 20; (2012); p. 6063 – 6072,10;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics