Category: 314741-39-4piperazines

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.314741-39-4,(S)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate,as a common compound, the synthetic route is as follows.

EXAMPLE 4; (8aS)-N-q,3-Dichlorophenyl)-l,3-dioxo-2-ralphaS,2R)-2- phenylcyclopropyllhexahydroimidazorLS-alpyrazine-TflHVcarboxamide (D3); Step 1 : 1-tert-Butyl 3-methyl (3S)-4-((r(lS.2R)-2-phenylcvclopropyllaminolcarbonvn-1.3- piperazinedicarboxylate (Dl); A solution of l-tert-buty 3-methyl (35)-l,3-piperazinedicarboxylate (AA3) in DCM (0.17 M) was added to a stirred solution of [(li?,25)-2-isocyanatocyclopropyl]benzene (1.0 eq.) in DCM (0.17 M) and the mixture was stirred at RT for 1 h. Solvents were evaporated under reduced pressure to give the title compound that was used as such in next step. MS (ES+) C2iH2gN3theta5 requires 403, found: 404 (M+H)+., 314741-39-4

314741-39-4 (S)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate 1501855, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.; BRANCA, Danila; FERRIGNO, Federica; HERNANDO, Jose, Ignacio, Martin; JONES, Philip; KINZEL, Olaf; MALANCONA, Savina; MURAGLIA, Ester; PALUMBI, Maria, Cecilia; PESCATORE, Giovanna; SCARPELLI, Rita; WO2010/23480; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.314741-39-4,(S)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate,as a common compound, the synthetic route is as follows.

A mixture of (S)-tert-butyl methyl piperazine- 1,3 -dicarboxylate (366 mg, 1.5 mmol) and HC1 in MeOH (20 mL, 2.9 M) was stirred at RT for 1 h. Themixture was concentrated in vacuo to yield the crude product (270 mg) as a yellow solid which was used directly in next step without further purification.

314741-39-4, The synthetic route of 314741-39-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ARAXES PHARMA LLC; JANES, Matthew, Robert; PATRICELLI, Matthew, Peter; LI, Liansheng; REN, Pingda; LIU, Yi; (397 pag.)WO2016/44772; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

314741-39-4, (S)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

314741-39-4, To a solution of (S)-1-tert-butyl 3-methyl piperazine-1,3-dicarboxylate (500 mg, 2.05 mmol) in anhydrous dichloromethane (20 mL) at 0 C. was added triethylamine (311 mg 3.1 mmol) and acetyl chloride (0.16 mL, 2.25 mmol). The mixture was stirred for 30 minutes, and then the mixture was diluted with dichloromethane. The organic layer was washed with H2O, dried with MgSO4, filtered and concentrated under reduced pressure to provide the titled compound.

314741-39-4 (S)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate 1501855, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Altenbach, Robert J.; Liu, Huaqing; Clapham, Bruce; Aguirre, Ana L.; Cowart, Marlon; Koenig, John R.; Sarris, Katerina; Scanio, Marc J.; Swinger, Kerren K.; Vasudevan, Anil; Villamil, Clara I.; Woller, Kevin R.; US2015/210720; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics