Category: 31166-44-6piperazines

31166-44-6, 1-Cbz-Piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0512] Benzyl piperazine-1-carboxylate 23 (27 .3 mL,142.2 mmol) was dissolved in dry THF (313.1 mL) andoxetan-3-one (12.29 g, 10.93 mL, 170.6 mmol) was added.The resulting solution was cooled in an ice-bath. NaBH(Oac )3 (59.99 g, 284.4 mmol) was added portionwise over 30mins, about a quarter was added. Mixture removed from icebath, allowed to warm to room temperature then continuedadding the NaBH(Oac )3 portionwise over 30 mins. On completeaddition, an exotherm from 22¡ã C. slowly to 32¡ã C. wasobserved, whereby the mixture was subsequently cooled onan ice bath until an internal of 22¡ã C. was reached. The icebath was removed and the reaction mixture’s internal tempwas steady at 22¡ã C. The mixture was stirred at room temperatureovernight. [0513] The resulting white suspension was quenched byaddition of 2M sodium carbonate solution (approx 150 mL)(pH=8) and concentrated under reduced pressure to removeTHF. Product was then extracted with EtOAc (3×250 mL).Organics were combined, dried over MgS04 , filtered andconcentrated under reduced pressure to leave product 24 as awhite solid (32.7 g 83percent yield). 1H NMR (500 MHz, DMSOd6)o 7.39-7.30 (m, 5H), 5.07 (s, 2H), 4.52 (t, 2H), 4.42 (t,2H), 3.43-3.39 (m, 5H) and 2.22 (t, 4H). MS (ES+) 276.8., 31166-44-6

As the paragraph descriping shows that 31166-44-6 is playing an increasingly important role.

Reference£º
Patent; Charrier, Jean-Damien; Davis, Christopher John; Fraysse, Damien; Etxebarria I Jardi, Gorka; Pegg, Simon; Pierard, Francoise; Pinder, Joanne; Studley, John; Zwicker, Carl; Sanghvi, Tapan; Waldo, Michael; Medek, Ales; Shaw, David Matthew; Panesar, Maninder; Zhang, Yuegang; Alem, Naziha; US2015/158872; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

31166-44-6, 1-Cbz-Piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Piperazine-1-carboxylic acid benzyl ester (8.00 g; 36.3 mmol), 2-fluoro-4-methyl-l-nitro;benzene (4.70 g; 30.3 mmol) and potassium carbonate (8.5 g; 61.5 mmol) were stirred 3 hours in 50 mL DMSO at 80¡ãC. The reaction mixture was cooled to room temperature and 250 mL water was added. The mixture was extracted with diethyl ether (2 x 250 mL). The organic phase was washed with water (100 mL), 1 N HC1 (2 x 100 mL), brine (2 x 100 mL), dried with MgSC>4 and concentrated in vacuo to give 10.5 g (29.5 mmol; 97.6 percent) 4-(5-methyl-2-nitro-phenyl)-piperazine-l-carboxylic acid benzyl ester.

31166-44-6, As the paragraph descriping shows that 31166-44-6 is playing an increasingly important role.

Reference£º
Patent; H. LUNDBECK A/S; WO2006/7843; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31166-44-6,1-Cbz-Piperazine,as a common compound, the synthetic route is as follows.

31166-44-6, Into a 1 L round-bottom flask was placed benzyl piperazine-l-carboxylate (15 g, 68.10 mmol, 1.00 equiv), 4-(tetramethyl- l,3,2-dioxaborolan-2-yl)benzoic acid (16.9 g, 68.12 mmol, 1.00 equiv), EDC (14.4 g, 75.12 mmol, 1.10 equiv), HOBt (5.8 g, 42.92 mmol, 0.50 equiv), and triethylamine (27.6 g 272.75 mmol, 4.00 equiv) in dichloromethane (300 mL). The resulting solution was stirred for 18 h at RT. The mixture was then washed with 0.5M sodium carbonate (aq, 75 mL). The resulting mixture was then washed with 0.5M HC1 (aq, 75 mL) followed by 0.5M sodium carbonate (aq, 75 mL). The solution was concentrated in vacuo and the crude product was recrystallized from tBME/hexane (1: 1). This afforded the title compound (26 g, 84percent) as a white solid. LC-MS (ES, m/z): 451[M+H]+

31166-44-6 1-Cbz-Piperazine 643495, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; FORMA THERAPEUTICS, INC.; BAIR, Kenneth, W.; LANCIA, David, R.; LI, Hongbin; LOCH, James; LU, Wei; MARTIN, Matthew, W.; MILLAN, David, S.; SCHILLER, Shawn, E.r.; TEBBE, Mark, J.; WO2014/164749; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31166-44-6,1-Cbz-Piperazine,as a common compound, the synthetic route is as follows.

General procedure: N-Cbz piperazine (0.55 g, 2.48 mmol, 1 eq) and carboxylic acid 8c?g (2.48 mmol, 1 eq) were dissolved in dry DMF (10 mL), the reaction mixture flushed with argon and cooled to 0 ¡ãC. N-methyl morpholine (NMM; 7.44 mmol,3 eq), hydroxybenzotriazole hydrate (HOBt; 2.98 mmol,1.2 eq) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimidehydrochloride HCl salt (EDC; 3.22 mmol, 1.3 eq) were slowly added. The reaction mixture was stirred under argon atmosphere for 5 h at 0 ¡ãC and an additional 15 h at room temperature. DMF was evaporated under reduced pressure and the residue redissolved in dichloromethane (10 mL).The dichloromethane phase was washed with H2O (1 x 10 mL), a 1 M HCl solution (3 x 10 mL), saturated aqueous NaHCO3 solution (3 9 10 mL), brine (1 x 20 mL), dried over Na2SO4, filtered, and the solvent evaporated under reduced pressure. The crude product was purified by flash column chromatography using ethyl acetate/hexane solvents as eluents to afford compounds 9c?g.

31166-44-6, As the paragraph descriping shows that 31166-44-6 is playing an increasingly important role.

Reference£º
Article; Juki?, Marko; Frlan, Rok; Chan, Fiona; Kirby, Robert W.; Madge, David J.; Tytgat, Jan; Peigneur, Steve; Anderluh, Marko; Kikelj, Danijel; Medicinal Chemistry Research; vol. 24; 6; (2015); p. 2366 – 2380;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31166-44-6,1-Cbz-Piperazine,as a common compound, the synthetic route is as follows.

31166-44-6, To a solution of benzyl piperazine-1 -carboxylate (1 .10 g, 4.99 mmol) and 1 -bromo-3-diethoxyphosphoryl-propane (1 .29 g, 4.99 mmol) in CH3CN (40.00 mL) was added K2003 (1 .38 g, 9.98 mmol). The reaction mixture was stirred at 75 00 overnight and then EtOAc (50 mL) and water (30 mL) were added. The layers were separated, and the aqueous phase was extracted again with EtOAc (20 mLx2). The combined organic phases were washed with brine (40 mL), dried over anhydrous Mg504, filtered andconcentrated. The residue was purified by flash column chromatography on silica gel to afford Compound 15.la (EtOAc/MeOH=50:1) to afford (1.80 g, 4.52 mmol, 91percent yield) as an oil. 1H NMR (400 M, ODd3), oe7.35 (m, 5H), 5.13 (s, 2H), 4.12 (m, 4H), 3.52 (m, 4H), 2.42 (m, 6H), 1.78 (m, 4H), 1.32 (m, 6H).

31166-44-6 1-Cbz-Piperazine 643495, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; UNITY BIOTECHNOLOGY, INC.; BACKES, Bradley; W. VON GELDERN, Thomas; CHEN, Bing; (121 pag.)WO2017/101851; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31166-44-6,1-Cbz-Piperazine,as a common compound, the synthetic route is as follows.

Compound BB-17-1 (7.0g, 31.78mmol) was dissolved in dilute hydrochloric acid (6M, 150mL) with stirring until homogeneous under nitrogen protectionskid slowly dropwise a solution of sodium nitrite (4N, 30 mL), then stirred at room temperature about one hour, 100mL of water was added with ethylacetate and extracted (100mL ¡Á 3).The combined organic phases were washed with saturated brine (20 mL), dried over anhydrous sodium sulfate, and under reduced pressure to removethe solvent, the resulting target compound BB-17-2 (7.5g, yield: 66%), was used directly in the next step without further purification.

31166-44-6, The synthetic route of 31166-44-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Changzhou Yin Sheng Pharmaceutical Co., Ltd.; Sichuan University; Zhang, Yang; Fu, Zhifei; Li, Jian; Chen, Shuhui; Wei, Yuquan; Tao, Xin; (65 pag.)CN105732602; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics