Category: 31166-44-6

31166-44-6, 1-Cbz-Piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of benzyl piperazine- l-carboxylate (400 mg, 1.818 mmol), l-bromo-2-(2- (2-methoxyethoxy)ethoxy)ethane (620 mg, 2.727 mmol) and K2CO3 (501 mg, 3.636 mmol) in ACN (20 mL) was stirred at 70 C overnight under a N2 atmosphere. The mixture was cooled to rt, then concentrated in vacuo, and water (10 mL) was added to the residue and the mixture was extracted with EtOAc (15 mL x 3), the combined organic phases were washed with brine (50 mL). The organic layer was dried over anhydrous Na2S04 and then concentrated in vacuo. The residue was purified by column chromatography on silica gel (PE:EtOAc = 10: 1 ~ 6: 1) to give a colorless oil (500 mg, 82%)., 31166-44-6

As the paragraph descriping shows that 31166-44-6 is playing an increasingly important role.

Reference£º
Patent; CAMP4 THERAPEUTICS CORPORATION; BUMCROT, David, A.; SEHGAL, Alfica; HERTZOG, Donald L.; (172 pag.)WO2019/195789; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

31166-44-6, 1-Cbz-Piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 1-Cbz piperazine (1 g, 4.55 mmol),2-bromo-2-methylpropionamide (751 mg, 4.55 mmol),potassium carbonate (942 mg, 6.83 mmol) and acetonitrile (10 mE) was stirred at 80¡ã C. overnight. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel colunm chromatography to obtain 57-c (1.05 g, 76percent). EC-MS (ESI): mlz 306.3 (M+H)., 31166-44-6

The synthetic route of 31166-44-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SHANGHAI YINGLI PHARMACEUTICAL CO., LTD; XU, Zusheng; (174 pag.)US2016/214994; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31166-44-6,1-Cbz-Piperazine,as a common compound, the synthetic route is as follows.

4.1.14 (3-Trifluoromethyl-1-phenyl-1H-pyrazol-5-yl)piperazine (12e) To a solution of 10a (19.0 g, 86.3 mmol) in pyridine (150 mL) was added acetic anhydride (9.0 mL, 95 mmol) at room temperature. The mixture was stirred for 18 h, and then concentrated under reduced pressure. The residue was poured into a 10percent aqueous citric acid solution and extracted with ethyl acetate. The extract was washed with brine, dried and concentrated under reduced pressure to give 4-acetyl-1-benzyloxycarbonylpiperazine (22.6 g, 100percent) as an oil. 1H NMR (300 MHz, DMSO-d6): delta 2.78 (2H, s), 3.35-3.68 (8H, m), 5.10 (2H, s), 7.28-7.42 (5H, m).

31166-44-6, As the paragraph descriping shows that 31166-44-6 is playing an increasingly important role.

Reference£º
Article; Yoshida, Tomohiro; Akahoshi, Fumihiko; Sakashita, Hiroshi; Kitajima, Hiroshi; Nakamura, Mitsuharu; Sonda, Shuji; Takeuchi, Masahiro; Tanaka, Yoshihito; Ueda, Naoko; Sekiguchi, Sumie; Ishige, Takayuki; Shima, Kyoko; Nabeno, Mika; Abe, Yuji; Anabuki, Jun; Soejima, Aki; Yoshida, Kumiko; Takashina, Yoko; Ishii, Shinichi; Kiuchi, Satoko; Fukuda, Sayaka; Tsutsumiuchi, Reiko; Kosaka, Keigo; Murozono, Takahiro; Nakamaru, Yoshinobu; Utsumi, Hiroyuki; Masutomi, Naoya; Kishida, Hiroyuki; Miyaguchi, Ikuko; Hayashi, Yoshiharu; Bioorganic and Medicinal Chemistry; vol. 20; 19; (2012); p. 5705 – 5719;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

31166-44-6, 1-Cbz-Piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of tetrahydro-pyran-4-carboxylic acid (0.477 g, 2.27 mmol, 1.0 eq. ) EDCA (0.480 g, 2.50 mmol, 1.1 eq. ) and HOBt (0. 340 g, 2. 50 mmol, 1.1 eq. ) in THF/DMF (8 mL/2 mL) is kept under magnetic stirring at room temperature for about I hour. PIPERAZINE-L-CARBOXYLIC acid benzyl ester (0.438 mL, 2.27 mmol, 1. 0 eq. ) is then added and the resulting reaction mixture is left to react for 14 hours. AcOEt (10 mL) and a 10percent solution OF NAHCO3 (10 mL) are added and the phases are separated. The organic phase is then washed with water (2×10 mL) and brine (10 mL), dried on N2aSO4, filtered and the solvent removed by evaporation under reduced pressure. 4-(Tetrahydr-pyran-4-carbonyl)- piperazine-1-carboxylic acid benzyl ester (32) is obtained as an ivory coloured solid (0. 613 g, I. 85 mmol, yield = 81percent) which does not require further purification. HPLC (method A): Rt=7.71 min., 31166-44-6

The synthetic route of 31166-44-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MENARINI RICERCHE S.P.A.; WO2004/94412; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

31166-44-6, 1-Cbz-Piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,31166-44-6

Step 1 Preparation of Compound 132To a suspension of NaOt-Bu (3.73 g, 38.9 mmol), Pd(dba)2 (0.298 g, 0.518 mmol), RuPhos (0.484 g, 1.036 mmol) and 2-bromo-l,4-difluorobenzene (5 g, 25.9 mmol) in Toluene (50 ml) was added benzyl piperazine-l-carboxylate (6.00 ml, 31.1 mmol) at r.t. under N2.The mixture was stirred at 100¡ãC under N2 for 1 hr. The reaction mixture was diluted with H20 and AcOEt at r.t., then the resulting solid was filtered, rinsed with AcOEt and H2O.The filtrate was extracted with AcOEt x 2. The organic layers were combined and washed with brine. The organic layer was dried over MgS04, filt and cone. The crude product was added to a silica gel column and was eluted with AcOEt-Hexane. Collected fractions were evaporated. The residual oil was triturated with CH2C12-Hexane, then filtered, rinsed with Hexane to afford compound 132 (3.7 g, 43.0 percent) as a white solid.1H-NMR (CDC13) delta: 7.40-7.29 (5H, m), 7.01-6.89 (1H, m), 6.66-6.56 (2H, m), 5.16 (2H, s), 3.67 (4H, t, J= 5.1 Hz), 3.11-2.97 (4H, m).

As the paragraph descriping shows that 31166-44-6 is playing an increasingly important role.

Reference£º
Patent; Shionogi & Co., Ltd.; KUROSE, Noriyuki; WO2011/162409; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31166-44-6,1-Cbz-Piperazine,as a common compound, the synthetic route is as follows.

N-(4-Bromophenyl)-4-methoxybenzamide (2 g, 6.53 mmol), Cbz-piperazine (1.38 g, 7.18 mmol), XPhos (623 mg, 1.31 mmol) and NaO/Bu (1.38 g, 14.4 mmol) were suspended in dioxane (20 ml) and degassed with nitrogen for 30 minutes. [Pd2(dba)3] (598 mg, 0.65 mmol) was then added and the reaction mixture was heated to 90 C for 2 h under N2. The re action was allowed to cool to rt and diluted with H20. The precipitate formed was collected by filtration and washed with H20. The dry residue (3.7 g) was triturated with diethyl ether to afford the title compound (2.85 g, 98%) as a brown solid. NMR (400 MHz, DMSO): d 9.92 (s, 1H), 7.94 (d, J=8.9 Hz, 2H), 7.62 (d, J=9.2 Hz, 2H), 7.40 (d, J=4.5 Hz, 4H), 7.38 – 7.31 (m, 1H), 7.05 (d, J=8.9 Hz, 2H), 6.95 (d, J=9.2 Hz, 2H), 5.12 (s, 2H), 3.84 (s, 3H), 3.59 – 3.56 (m, 4H), 3.09 (dd, J=5.0, 5.0 Hz, 4H). LC-MS: Rt = 1.69 min, m/z = 446, [M+H]+.

31166-44-6, 31166-44-6 1-Cbz-Piperazine 643495, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BORRONI, Edilio; GOBBI, Luca; HONER, Michael; EDELMANN, Martin; MITCHELL, Dale; HARDICK, David; SCHMIDT, Wolfgang; STEELE, Christopher; MULLA, Mushtaq; (151 pag.)WO2019/121661; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31166-44-6,1-Cbz-Piperazine,as a common compound, the synthetic route is as follows.

In a 250 ml round bottomed flask 5-(3-(1-hydroxyethyl)-1-oxo-1H-isochromen-4- yl)thiophene-2-carbaldehyde (Intermediate B37) (780 mg, 2.60 mmol) was dissolved in 30 ml of DCM then acetic acid (0.446 ml, 7.79 mmol) and benzyl piperazine-1-carboxylate (1.503 ml, 7.79 mmol) were added. After few minutes SODIUM TRIACETOXYHYDROBORATE (2.75 g, 12.99 mmol) was added and the mixture was stirred at r.t. The mixture was poured into 100 ml of DCM and 100 NaHCO3 sat. sol. then phases were separated and the organic one was concentrated to dryness to leave a brown oil that was immediately purified by chromatography eluting with HexaneEtOAcmixtures to leave the title compound (903 mg, 1.790 mmol, 68.9 percent yield) as a yellow oil.UPLC-MS: 0.79 mm, 505.12 [M+H]+, method 9, 31166-44-6

31166-44-6 1-Cbz-Piperazine 643495, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; CHIESI FARMACEUTICI S.P.A.; BIAGETTI, Matteo; CAPELLI, Anna Maria; ACCETTA, Alessandro; CARZANIGA, Laura; WO2015/91685; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

31166-44-6, 1-Cbz-Piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

IBenzyl piperazine-1-carboxylate (1.05 mL, 5.25 mmol) and potassium carbonate (1.38 g, 10 mmol) were added to a solution of 4-fluoro-2-methyl-1-nitro-benzene (776 mg, S mmol) in DMF (10 mL) and the resulting mixture was stirred at 100 ¡ãC for 18 h. Water was added to the reaction mixture and extraction performed with ethyl acetate. The combinedorganic layers were washed with brine, dried over sodium sulfate and concentrated in vacuo. The crude product was purified by silica column chromatography (heptane/ethyl acetate = 1/0 to 6/4 v/vpercent) to yield the title compound (1.7S g, 98percent)., 31166-44-6

31166-44-6 1-Cbz-Piperazine 643495, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; NETHERLANDS TRANSLATIONAL RESEARCH CENTER B.V.; DE ROOS, Jeroen; UITDEHAAG, Joost, Cornelis, Marinus; DE MAN, Adrianus, Petrus, Antonius; BUIJSMAN, Rogier, Christiaan; ZAMAN, Guido, Jenny, Rudolf; (79 pag.)WO2016/166255; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

31166-44-6, 1-Cbz-Piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: General method for the peptide coupling step (C) Under inert atmosphere and at room temperature, to a solution of the previously obtained piperazine (1 .85 mmol, 1 eq.) in dichloromethane (DCM, 15 ml) were successively added: N-(3-Dimethylaminopropyl)-N’-ethylcarbodiimide (EDC, 1.85 mmol, 1 eq.), 1- hydroxybenzotriazole (0.37 mmol, 0.2 eq.), the corresponding Boc-protected aminoacid (1.85 mmol, 1 eq.) and N-methylmorpholine (5.55 mmol, 3 eq.). After 12 hours of stirring, the reaction mixture was diluted by addition of 75 ml of DCM and washed with citric acid (aq soln. 10percent, 3 x 50 ml) and then with brine. The organic phase was subsequently dried over magnesium sulfate, filtered and the solvent evaporated under vacuum. The crude product was purified by flash-chromatography to give the desired coupling product. (a) benzyl 4-[2-(tert-butoxycarbonylamino)acetyl]piperazine-1-carboxylate (3a) The crude derivative obtained following the general protocol described before was purified by flash-chromatography (eluent: EtOAc/PE 5/5). C19H27N3O5; yield 95percent; white solid; m.p. 66-67 ¡ãC; M = 377.43 g/mol; IR (ATR): v = 3329 (w), 2971 (w), 1691 (s), 1627 (m), 1527 (m), 1420 (m), 1223 (s), 1153 (m), 756 (m), 695 (m) cm ; H NMR (250 MHz, CDCI 3) delta 7.40-7.32 (m, 5H), 5.48 (as, 1 H), 5.14 (s, 2H), 3.96 (d, J = 4.4 Hz, 2H), 3.69-3.60 (m, 2H), 3.53-3.49 (m, 4H), 3.45-3.47 (m, 2H), 1.44 (s, 9H); C NMR (63 MHz, CDCI 3) delta 167.2 (C q), 155.9 (Cq), 155.2 (C q), 136.4 (C q), 128.7 (2CH), 128.4 (CH), 128.2 (2CH), 79.9 (C q), 67.7 (CH 2), 44.3 (CH 2), 43.7 (CH 2), 43.6 (CH 2), 42.4 (CH 2), 41.8 (CH 2), 28.5 (3CH 3); MS: m/z = 400 [M + Na] ;

31166-44-6, The synthetic route of 31166-44-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTON UNIVERSITY; GRIFFIN, Martin; RATHBONE, Daniel; BADARAU, Leonas Eduard; WO2014/57266; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31166-44-6,1-Cbz-Piperazine,as a common compound, the synthetic route is as follows.

31166-44-6, Dissolve compound 13 (500 g, 2.27 mol) in concentrated hydrochloric acid (1250 mL) And water (1250 mL),Then add sodium nitrite (469.89 g, 6.81 mol) dropwise at 25-30C within one hour.Dissolved in water (1000 mL) solution.The reaction was stirred at 25 C for 1 hour.TLC (petroleum ether: ethyl acetate = 1:1) showed complete reaction. The reaction was poured into ethyl acetate (2 L), the layers were separated and the aqueous layer was extracted with ethyl acetate (1 L x 2). The organic layers were combined, washed with 1 L of saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated to give the title compound 14 (yellow oil, 560 g, yield: 94.58%). It was used in the next step without purification.

31166-44-6 1-Cbz-Piperazine 643495, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; CHANGZHOU YINSHENG PHARMACEUTICAL CO., LTD.; FU, ZHIFEI; ZHANG, YANG; CHEN, SHUHUI; (29 pag.)TW2017/34011; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics