Category: 30459-17-7piperazines

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A dichloromethane solution (6mL) of an appropriate piperazine (1 eq) and triethylamine (3 eq) was added drop wise to a suspension of 2-chloro-N-(5-nitrothiazol-2-yl)acetamide (1) in 5mL CH2Cl2 and the reaction was kept at room temperature under a nitrogen atmosphere and stirring for 48h. The reaction solvent was evaporated and the residue was redissolved in ethyl acetate. The inorganic salts were filtered away and the residue was chromatographed on preparative TLC silica gel plates with ethyl acetate/petroleum ether as eluent to obtain the desired pure product as a powder or crystals. Purity was also checked by HPLC and it was ?95%. Orange powder (55%): mp 173-175C; 1H NMR (400MHz, (CDCl3) delta: 8.33 (s, 1H), 7.51 (d, J=8.4Hz, 2H), 6.96 (d, J=8.4Hz, 2H), 3.40 (s, 2H), 3.38 (t, J=5.2Hz, 4H), 2.82 (t, J=5.2Hz, 4H). HRESIMS calcd for C16H16N8O4S m/z [M+H]+ 416.1010, found 416.1005, 30459-17-7

The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Papadopoulou, Maria V.; Bloomer, William D.; Rosenzweig, Howard S.; Wilkinson, Shane R.; Szular, Joanna; Kaiser, Marcel; European Journal of Medicinal Chemistry; vol. 117; (2016); p. 179 – 186;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

EXAMPLE 7 9-{4-[4-(4-Trifluoromethyl-phenyl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoroethyl)-amide Prepared analogously to Example 2 b from 1-(4-trifluoromethyl-phenyl)-piperazine and 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoroethyl)-amide. Yield: 0.23 g (48.7% of theoretical). Melting point: 176 C., 30459-17-7

As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference£º
Patent; Boehringer Ingelheim Pharm GmbH & Co, KG; US6818644; (2004); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 2. Preparation of 4-[4-(4-trifluoromethyl-phenyl)-piperazin-l- yl]-butyric acid ethyl ester intermediate.Ethyl-4-bromobutyrate (390 mg, 2.00 mmol) and triethylamine (280 muL; 2.00 mmol) were added to a solution of l-(4-trifluoromethylphenyl)-piperazine (460 mg; 2.00 mmol) in tetrahydrofuran (3 mL). Potassium iodide (332 mg; 2.00 mmol) was added and the resulting suspension is irradiated in a mono-mode microwave oven for 2 hours at 1000C. The suspension is then diluted with dichloromethane (15 mL) and washed twice with water (5 mL). The organic phase is then dried over sodium sulphate and is concentrated under reduced pressure to afford the desired product (660 mg; 1.96 mmol)., 30459-17-7

As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference£º
Patent; INTERVET INTERNATIONAL B.V.; CHASSAING, Christophe Pierre Alain; MEYER, Thorsten; WO2010/115688; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: To the stirred solution of 3-(3-oxo-2H-benzo[b][1,4]thiazin-4(3H)-yl)propanoic acid (100mg, 0.448 mol) in DMF, N-phenyl piperzine derivatives (0.538 mol) or 3-(4-phenylpiperazin-1-yl)propan-1-amine derivatives (0.538 mol) was added at room temperature, followed by the addition of EDC:HCl (102 mg) and HOBt (60.5 mg), the stirring was continued for 12h. After completion of the reaction (TLC analysis), small amount of ice cold water (10 mL) was added to the reaction mixture and then extracted with chloroform (2 x 10 mL). The chloroform layer was separated, dried over Na2SO4 and evaporated under vacuum to give corresponding derivatives 8a-i and 10a-g in good yields., 30459-17-7

30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Venkatesh, Ramineni; Kasaboina, Suresh; Bidayat, Deepthi; Nikhil Kumar; Jain, Nishant; Tangeda, Saritha Jostna; Bantu, Rajashaker; Janardhan, Sridhara; Nagarapu, Lingaiah; Bioorganic and Medicinal Chemistry Letters; vol. 27; 2; (2017); p. 354 – 359;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

EXAMPLE 74 (2-Cyclopent-1-enyl-5-methanesulfonyl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone Following procedure E, (2-Cyclopent-1-enyl-5-methanesulfonyl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone is prepared from 2-cyclopent-1-enyl-5-methanesulfonyl-benzoic acid (Example H) and 1-(4-trifluoromethyl-phenyl)-piperazine: colourless foam, MS (ISP): 479.5 (M+H+).

30459-17-7, As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference£º
Patent; Alberati-Giani, Daniela; Jolidon, Synese; Narquizian, Robert; Nettekoven, Matthias Heinrich; Norcross, Roger David; Pinard, Emmanuel; Stalder, Henri; US2005/59668; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

To a solution of II-B-3 from Step 2 in THF (2 mL), was added N-(alpha,alpha,alpha-trifluoro-p-tolyl)piperazine (187 mg, 0.81 mmol, 1.0 equiv.), followed by Et3N (1.61 mmol, 2.0 equiv.). The reaction mixture was stirred at room temperature overnight. The solvent was evaporated and the residue was purified by chromatography. 1H NMR (400 MHz, CDCl3) delta ppm: 7.75 (m, 2H), 7.58 (m, 2H), 7.48 (d, 2H), 6.90(d, 2H), 3.76 (s, 3H), 3.74 (s, 2H), 3.65 (m, 4H), 3.22 (m, 4H)., 30459-17-7

The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Kalypsys, Inc.; US2005/234046; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of 4 (100 mg, 0.23 mmol) in acetonitrile (CH3CN, 10 mL) was added the corresponding arylpiperazines (1.2 equiv) and potassium carbonate (6.0 equiv). The reaction mixture was stirred at reflux for 16 h. After cooling to ambient temperature, the reaction mixture was filtered through a Buchner funnel. After filtration the filtrate was concentrated in vacuo and the residue was purified by silica gel column chromatography using ethyl acetate/petroleum ether (1:4, v/v) as eluent to afford the corresponding products, and all compounds were recrystallized from trichloromethane and n-hexane.

30459-17-7, As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference£º
Article; Xu, Fang; Chen, Hong; Xu, Jingyi; Liang, Xue; He, Xuelan; Shao, Binhao; Sun, Xianqiang; Li, Bing; Deng, Xiaoliang; Yuan, Mu; Bioorganic and Medicinal Chemistry; vol. 23; 24; (2015); p. 7735 – 7742;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 0.31 mmol 2-isopropylsulfanyl-5-nitro-benzoic acid in 5 ml tetrahydrofuran were added successively 0.31 mmol TBTU, 0.84 mmol N-ethyldiisopropylamine and 0.22 mmol 1-(4-trifluoromethylphenyl)-piperazine (commercially available, e.g. from Fluorochem). The reaction mixture was stirred at 35 C. for 16 h and then concentrated in vacuo. Chromatography (SiO2, ethyl acetate/heptane) followed by trituration in pentane afforded the title compound as a yellow solid (yield 83%). MS (m/e): 454.4 (M+H+, 100%)., 30459-17-7

The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Jolidon, Synese; Narquizian, Robert; Norcross, Roger David; Pinard, Emmanuel; US2006/149062; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

At 0C under nitrogen, 366mg of commercially available 2-chloropyridine-4-carbonyl chloride dissolved in 2ml of dichloromethane were added dropwise to a solution of 530mg of commercially available 4-(1 -piperazinyl)-2-trifluoromethylbenzonitrile in 5ml ofdichloromethane and 630mg of Et3N. The reaction mixture was stirred overnight at room temperature, poured over a stirred mixture of 100ml EtOAc and 40ml of water. The aqueous layer was extracted with EtOAc. The combined organic layers were washed with brine, dried over MgS04, filtered, concentrated under vacuum and purified by column chromatography on silica gel to isolate 620mg of 4-{4-[(2-chloropyridin-4-yl)carbonyl]piperazin-1 -yl}-2- (trifluoromethyl)benzonitrile. 99mg of this material were then added to a degased mixture of 85mg of commercially available 1 -(4-trifluoromethylphenyl)piperazine, 6mg of Pd(OAc)2, 23mg of RuPhos, 163mg of Cs2C03, and 1 .5ml of ie/f-Butanol then, heated to 85 C overnight. The reaction mixture was then poured at room temperature over a stirred mixture of 50ml of EtOAc and 10ml of water. The aqueous layer was extracted with 10ml EtOAc. The combined organic layers were washed with brine, dried over MgS04, filtered, concentrated under vacuum and purified by column chromatography to isolate 60mg of compound No. 32 in Table 2., 30459-17-7

30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; NOVARTIS TIERGESUNDHEIT AG; GAUVRY, Noelle; PAUTRAT, Francois; WO2015/71417; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

EXAMPLE 46 5-(3,4-Dimethoxybenzylamino)-2-(2-furyl)-8-[4-(4-trifluoromethylphenyl)piperazin-1-ylmethyl][1,2,4]triazolo[1,5-c]pyrimidine (Compound 46) The subject compound (quantitative) was obtained as a pale brown oily matter from 5-(3,4-dimethoxybenzylamino)-8-formyl-2-(2-furyl)[1,2,4]triazolo[1,5-c]pyrimidine and 1-(4-trifluoromethylphenyl)piperazine in a manner similar to that in Example 1. 1H NMR (CDCl3, delta, ppm): 2.75 (t, J=5.0 Hz, 4H), 3.31 (t, J=5.0 Hz, 4H), 3.88 (s, 3H), 3.88 (s, 3H), 3.90 (s, 2H), 4.76 (d, J=5.6 Hz, 2H), 6.44 (t, J=5.6 Hz, 1H), 6.57 (dd, J=1.7, 3.3 Hz, 1H), 6.85 (d, J=8.0 Hz, 1H), 6.90 (d, J=8.9 Hz, 2H), 6.95 (s, 1H), 6.96 (d, J=8.0 Hz, 1H), 7.22 (d, J=3.3 Hz, 1H), 7.45 (d, J=8.9 Hz, 2H), 7.60 (d, J=1.7 Hz, 1H), 7.96 (s, 1H)

30459-17-7, As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference£º
Patent; Uesaka, Noriaki; Imma, Hironori; Kashima, Hajime; Kurokawa, Masako; Nonaka, Hiromi; Kanda, Tomoyuki; Kuwana, Yoshihisa; Toki, Shinichiro; Shimada, Junichi; US2004/110826; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics