Category: 30459-17-7

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

3-(2-Thienyl) propanoic acid (50 mg, 0.32 mmol), HOBt (47 mg, 0.35 mmol), TBTU (1 13 mg, 0.35 mmol), anhydrous triethylamine (71 ??, 0.51 mmol) and dry DMF (2 ml) were placed in an oven-dried Schlenk tube under a nitrogen atmosphere. The resulting solution was stirred at room temperature for 15 minutes. A second Schlenk tube was prepared containing 1-(4-trifluoromethyl phenyl) piperazine (81 mg, 0.35 mmol and dry DMF (1 ml) under a nitrogen atmosphere. The resulting solution was stirred until complete dissolution of the piperazine had occurred. The piperazine solution was then transferred, via a cannula, to the first Schlenk tube containing the carboxylic acid. The resulting solution was stirred for 24 hrs, under nitrogen, and monitored by TLC. After 24 hrs, the DMF was removed under reduced pressure and the resulting oil was acidified using a 0.1 M hydrochloric acid solution. The aqueous mixture was extracted with dichloromethane (20 ml, followed by 4 x 10 ml) and the organic layer washed with a saturated sodium bicarbonate solution (3 x 20 ml) and brine (3 x 20 ml). The organic layer was dried over magnesium sulphate and evaporated under reduced pressure. The residue was purified using flash chromatography (3:2, EtOAc:n-hexane) to obtain the desired product in an 44 % yield. H NMR (300 MHz, CDCI3) ? 7.48 , (d, 2H), 7.1 1 (dd, 1 H), 6.88-6.93 (m, 2H), 6.84-6.85 (m, 2H), 3.76 (t, 2H), 3.57 (t, 2H), 3.17-3.26 (m, 6H), 2.69 (t, 2H). MS (+ESI) calcd for C18 H19 F3 N2 O m/z: [M + H]+ , 368.1 164; found 369.1243 [Diff(ppm) = -1.25].

30459-17-7, As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference£º
Patent; NATIONAL UNIVERSITY OF IRELAND, MAYNOOTH; STEPHENS, John; FINDLAY, John; KINSELLA, Gemma; MARTIN, Darren; DEVINE, Robert; VELASCO-TORRIJOS, Trinidad; WO2013/60860; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

Azelaic acid (326 mg, 1.74 mmol), HOBt (1 17 mg, 0.87 mmol), TBTU (279 mg, 0.87 mmol), anhydrous triethylamine (121 ??, 1 .39 mmol) and dry DMF (2 ml) were placed in an oven-dried Schlenk tube under a nitrogen atmosphere. The resulting solution was stirred at room temperature for 15 minutes. A second Schlenk tube was prepared containing 1-(4-trifluoromethyl phenyl) piperazine (200 mg, 0.87 mmol) and dry DMF (1 ml) under a nitrogen atmosphere. The resulting solution was stirred until complete dissolution of the piperazine had occurred. The piperazine solution was then transferred, via a cannula, to the first Schlenk tube containing the carboxylic acid. The resulting solution was stirred for 24 hrs, under nitrogen, and monitored by TLC. After 24 hrs, the DMF was removed under reduced pressure and the resulting oil was acidified using a 0.1 M hydrochloric acid solution. The aqueous mixture was extracted with dichloromethane (20 ml, followed by 4 x 10 ml) and the organic layer washed with a saturated sodium bicarbonate solution (3 x 20 ml) and brine (3 x 20 ml). The organic layer was dried over magnesium sulphate and evaporated under reduced pressure. The residue was purified using flash chromatography (DCM followed by 9.5: 0.5, DCM:MeOH) to obtain the desired product as a white solid in a 60% yield. H NMR (300 MHz, CDCI3) ? 7.49 (d, 2H), 6.91 (d, 2H), 3.77-3.78 (m, 2H), 3.62-3.64 (m, 2H), 3.24-3.31 (m, 2H), 2.33- 2.39 (m, 2H), 1.60-1.68 (m, 4H), 1.33-1.38 (m, 6H). MS (+ESI) calcd for C20 H27 F3 N2 03 m/z: [M + H]+, 401 .2047; found 401.2047 [Diff(ppm) = 0].

30459-17-7, 30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; NATIONAL UNIVERSITY OF IRELAND, MAYNOOTH; STEPHENS, John; FINDLAY, John; KINSELLA, Gemma; MARTIN, Darren; DEVINE, Robert; VELASCO-TORRIJOS, Trinidad; WO2013/60860; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To the stirred solution of 4-oxo-3, 4-dihydroquinazoline-2-carboxylic acid (0.1 g, 0.0005 mol) in N,N-dimethyl formamideDMF, N-phenyl piperzine derivatives (0.0005 mol),or 3-(4-phenylpiperazin-1-yl)propan-1-amine derivatives(9a-g, 0.0005 mol) were added at room temperature, followedby the addition of EDC HCl (0.0006 mol) and HOBt(0.0006 mol) and the mixture was stirred for 1 h. Aftercompletion of the reaction (TLC analysis), small amount ofice cold water (10 mL) was added to the reaction mixtureand then extracted with chloroform (2 ¡Á 10 mL). Thechloroform layer was separated, dried over Na2SO4, andevaporated under vacuum to give corresponding hybrids(10a-g, 11a-g) in good yields., 30459-17-7

The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Venkatesh, Ramineni; Kasaboina, Suresh; Janardhan, Sridhara; Jain, Nishant; Bantu, Rajashaker; Nagarapu, Lingaiah; Medicinal Chemistry Research; vol. 25; 9; (2016); p. 2070 – 2081;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: A 5.0 mL round-bottomed flask was equipped with a reflux condenser, 2.5 mol % chloro(1,5-cyclooctadiene)iridium (I) dimer [Ir(COD)Cl]2 and 5.0 mol % (S)-p-Tol-BINAP were added and followed by addition of anhydrous tetrahydrofuran (2.0 mL). After they were stirred for 10 min to produce a yellow solution. 1,4-Dihydro-1,4-epoxynaphthalene 1a (50 mg, 0.3468 mmol) was added; then 10 min later, additive of ammonium iodide (1.0 equiv. to 1a) was added and heated to reflux. At the first sign of reflux, N-substituted piperazine nucleophiles (2.0 equiv. to 1a) were added. The reaction mixture was stirred at reflux and monitored by TLC until completion (typically 6-12 h). The solvent was removed in vacuo and the crude mixture was purified by column chromatography on silica gel to afford the desired products., 30459-17-7

The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Yang, Wen; Luo, Renshi; Yang, Dingqiao; Molecules; vol. 20; 12; (2015); p. 21103 – 21124;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

5-Phenylpentanoic acid (105 mg, 0.59 mmol), HOBt (87 mg, 0.65 mmol), TBTU (208 mg, 0.65 mmol), anhydrous triethylamine (131 ??_, 0.94 mmol) and anhydrous DMF (2 mL) were placed in an oven-dried Schlenk tube under a nitrogen atmosphere. The resulting solution was stirred at room temperature for 15 minutes. A second Schlenk tube was prepared containing 1-(4- (trifluoromethyl)phenyl)piperazine (150 mg, 0.65 mmol) and anhydrous DMF (1 mL) under a nitrogen atmosphere. The resulting solution was stirred until complete dissolution of the piperazine had occurred. The piperazine solution was then transferred, via a cannula, to the first Schlenk tube containing the carboxylic acid. The resulting solution was stirred under nitrogen and monitored by TLC. After 24 hours, the DMF was removed under reduced pressure and the resulting oil was acidified using a 0.1 M HCI solution. The aqueous mixture was extracted with DCM (20 mL, followed by 4 x 10 mL) and the organic layer washed with a saturated sodium bicarbonate solution (3 x 20 mL) and brine (3 x 20 mL). The organic layer was dried over magnesium sulphate and the solvent removed in vacuo. The residue was purified using flash chromatography (3:2, EtOAc:n-hexane) to obtain the desired product in an 44 % yield. H NMR (300 MHz, CDCI3) ? 7.50-7.46 (m, 2H), 7.29- 7.14 (m, 5H), 6.91-6.87 (m, 2H), 3.74 (d, J = 4.5 Hz, 2H), 3.55 (d, J = 4.5 Hz, 2H), 3.20 (d, J = 3.6 Hz, 4H), 2.63 (d, J = 4.8 Hz, 2H), 2.35 (d, J = 4.8 Hz, 2H), 1.68 (d, J = 4.5 Hz, 4H). 3C NMR (75 MHz, CDCI3) 171.5, 152.9, 142.1 , 128.4, 128.3, 126.4 (q, J = 3 Hz), 125.8, 120.6 (q, J = 33 Hz), 1 19.2 (q, J = 271.5 Hz), 1 14.9, 48.3, 48.1 , 45.1 , 41.1 , 35.7, 33.1 , 31.1 , 24.8. MS (+ESI) calcd for C22 H25 F3 N2 O m/z: [M + Na]+, 413.181 1 ; found 413.1794 [Diff(ppm) = – 4.08].

30459-17-7, 30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; NATIONAL UNIVERSITY OF IRELAND, MAYNOOTH; STEPHENS, John; FINDLAY, John; KINSELLA, Gemma; MARTIN, Darren; DEVINE, Robert; VELASCO-TORRIJOS, Trinidad; WO2013/60860; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: Compounds 1a-l and compounds 15-19 were synthesized in the same reaction: In a dichloromethane solution (2-3 mL) of chloroacetylchloride(1.1 eq), a dichloromethane solution (8-10 mL) of the appropriate piperazine (1 eq) and triethylamine (2.5 eq) was added dropwise and the reaction mixture was stirred overnight at room temperature under a nitrogen atmosphere. The reaction mixture was evaporated and the residue was extracted with ethylacetate-brine. The organic layer was dried over Na2SO4 and chromatographed on silica preparative TLC to give the desired products.When the reaction was run for 2 h, compounds 1a-l were the mainproducts (>90%)., 30459-17-7

As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference£º
Article; Papadopoulou, Maria V.; Bloomer, William D.; Rosenzweig, Howard S.; O’Shea, Ivan P.; Wilkinson, Shane R.; Kaiser, Marcel; European Journal of Medicinal Chemistry; vol. 103; (2015); p. 325 – 334;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The appropriate 1-substituted piperazines (1 mmol)and Et3N (3 mmol) were added to a solution of 6-chloropurines(1mmol) (5, 6) in 5 mL of absolute EtOH. Themixture was refluxed for 8-16 h. The reaction mixture wasconcentrated in vacuo and the residue was purified by columnchromatography (EtOAC-hexane, 1:3 to 1:1).

30459-17-7, 30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Atalay, Rengul Cetin; Guven, Ebru Bilget; Kucukdumlu, Asligul; Tuncbilek, Meral; Acta Chimica Slovenica; vol. 67; 1; (2020); p. 70 – 82;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6-(Thiophen-2-yl) hexanoic acid (77 mg, 0.39 mmol), HOBt (58 mg, 0.43 mmol), TBTU (138 mg, 0.43 mmol), anhydrous triethylamine (87 ??, 0.63 mmol) and dry DMF (2 ml) were placed in an oven-dried Schlenk tube under a nitrogen atmosphere. The resulting solution was stirred at room temperature for 15 minutes. A second Schlenk tube was prepared containing 1-(4-trifluoromethyl phenyl) piperazine (100 mg, 0.43 mmol and dry DMF (1 ml) under a nitrogen atmosphere. The resulting solution was stirred until complete dissolution of the piperazine had occurred. The piperazine solution was then transferred, via a cannula, to the first Schlenk tube containing the carboxylic acid. The resulting solution was stirred for 24 hrs, under nitrogen, and monitored by TLC. After 24 hrs, the DMF was removed under reduced pressure and the resulting oil was acidified using a 0.1 M hydrochloric acid solution. The aqueous mixture was extracted with dichloromethane (20 ml, followed by 4 x 10 ml) and the organic layer washed with a saturated sodium bicarbonate solution (3 x 20 ml) and brine (3 x 20 ml). The organic layer was dried over magnesium sulphate and evaporated under reduced pressure. The residue was purified using flash chromatography (3:2, EtOAc:n-hexane) to obtain the desired product in an 75 % yield. H NMR (300 MHz, CDCI3) ? 7.48 (d, 2H), 7.08 (dd, 1 H), 6.88-6.93 (m, 3H), 6.76-6.77 (m, 1 H), 3.75 (t, 2H), 3.59 (t, 2H), 3.22-3.28 (m, 4H), 2.81 (t, 2H), 2.34 (t, 2H), 1.65-1.77 (m, 4H), 1.44-1.48 (m, 4H). MS (+ESI) calcd for C18 H21 F3 N4 O m/z: [M + Na]+ , 410.1621 ; found 433.1532 [Diff(ppm) = -1.15]., 30459-17-7

30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; NATIONAL UNIVERSITY OF IRELAND, MAYNOOTH; STEPHENS, John; FINDLAY, John; KINSELLA, Gemma; MARTIN, Darren; DEVINE, Robert; VELASCO-TORRIJOS, Trinidad; WO2013/60860; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: To a solution of carboxylic acid (50 mmol) in DMF (0.25 mL) in a 48 position Mettler Toledo XT reaction block was added PyBOP (50 mmol, 0.2 mL of 0.3 M solution in DMF) and TEA (75 mmol, 0.05 mL of 1.5 M solution in DMF) followed by the appropriate amine build blocks (55 mmol, 0.55 ml of 1 M solution in DMF). The reactions were stirred at rt 24 h and concentrated by GeneVac HT-4 to remove all reaction mixture including excess amine and DMF. The crude mixtures were dissolved in EtOAc (1 mL) and filtered through silica-packed short-column and washed with EtOAc (3 mL). The collected organic solution was concentrated in GeneVac HT-4 and dissolved in DMSO (1 mL). DMSO solution was subjected to HTAC for pre-purification analysis, purification, and final QC., 30459-17-7

The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Hwang, Jong Yeon; Attia, Ramy R.; Carrillo, Angela K.; Connelly, Michele C.; Guy, R. Kiplin; Bioorganic and Medicinal Chemistry Letters; vol. 23; 6; (2013); p. 1891 – 1895;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

3-(Trans-4-tert-butoxycarbonylamino-cyclohexyl)-propanoic acid (50 mg, 0.18 mmol) and 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (140 mg, 0.37 mmol) were dissolved in a mixture of dimethylacetamide (1.2 mL) and dichloromethane (0.3 mL). Next, diisopropylethylamine (100 muL, 0.55 mmol) was added. After 5 min, a solution of 1-(4-trifluormethyl-phenyl)-piperazine (50 mg, 0.22 mmol) in dimethylacetamide (1.2 mL) and dichloromethane (0.3 mL) was added, and the resulting mixture was stirred at room temperature for 30 min. The mixture was then diluted with dichloromethane (40 mL), and the organic layer was washed with water (2×20 mL), washed with saturated aqueous ammonium chloride (20 mL), washed with water (10 mL), washed with saturated aqueous hydrogencarbonate (2×20 mL), and washed with water (10 mL). The organic phase was dried over magnesium sulfate, filtered, and concentrated under vacuum. The crude product was purified by column chromatography on silica gel (pentane/ethyl acetate, 5:1), and the desired product was isolated as a light yellow solid (68 mg, 76% yield).

30459-17-7, The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; INTERVET INTERNATIONAL B.V.; WO2009/77527; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics