Category: 30459-17-7

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: The mixtures of (1,1′-thiocarbonyl) bis-1H-imidazole (5 mmol)and suitable derivative of piperazine or thiomorpholine (5 mmol)in methylene chloride (25 ml) were stirred for 24 h at room temperature.The solutions were extracted three times with distilledwater and the organic phases were dried over MgSO4 and evaporated. The obtained thioketones were refluxed for 2 h withhydrazine hydrate (5 mmol). The final thiosemicarbazides werecrystallized from dry methanol.

30459-17-7, As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference£º
Article; Mrozek-Wilczkiewicz, Anna; Malarz, Katarzyna; Rejmund, Marta; Polanski, Jaroslaw; Musiol, Robert; European Journal of Medicinal Chemistry; vol. 171; (2019); p. 180 – 194;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 3 (100 mg, 0.28 mmol), arylpiperazines or piperidines,K2CO3, (1.2 equiv), potassium carbonate (6.0 equiv) and CH3CN(25 mL) were placed in 50-mL round-bottomed flask equipped withmagnetic stirrer for 14 h at 85 C (monitored by TLC). After completionof reaction, the reaction mixture was filtered, and the filtrate wasconcentrated in vacuo. Then the residue was purified by chromatographyon silica-gel column (petroleum ether: ethyl acetate=5:1, v/v)to obtain the corresponding products (4-26), and all compounds wererecrystallized from dichloromethane and n-hexane.

30459-17-7, 30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Chen, Hong; Liang, Xue; Sun, Tao; Qiao, Xiaoguang; Zhan, Zhou; Li, Ziyong; He, Chaojun; Ya, Huiyuan; Yuan, Mu; Steroids; vol. 134; (2018); p. 101 – 109;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 3-Bromomethyl-benzenesulfonyl chloride (2.6 g, 9.65 mmol, 1.0 equiv.) and 1-(4-Trifluoromethyl-phenyl)-piperazine (2.2 g, 9.7 mmol, 1.0 equiv.) in THF (20 mL) was added Et3N (1.34 mL, 9.65 mmol, 1.0 equiv.). The resulting mixture was stirred at room temperature for 3 h and then diluted with ethyl acetate (100 mL). The diluted mixture was washed with water (2¡Á50 mL), brine and dried over Na2SO4. After removal of solvent, the crude product was purified by chromatography to give 4.08 g of desired product (99%). 1H NMR (400 MHz, CDCl3), delta (ppm): 7.81 (t, 1H), 7.71 (dt, 1H), 7.65 (d, 1H), 7.55 (t, 1H), 7.47 (d, 2H), 6.88 (d, 2H), 4.53 (s, 2H), 3.35 (m, 4H), 3.19 (m, 4H).

30459-17-7, As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference£º
Patent; Kalypsys, Inc.; US2005/234046; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: Compound 9a-9j were synthesized according to the procedure previously described.8 The above mixture (containing 8) was added a solution of amines (0.56 mmol) in dichloromethane (2 mL) in an ice bath. The reaction mixture was stirred overnight at room temperature, then added dropwise with saturated sodium bicarbonate solution in an ice bath, and the solution was extracted with dichloromethane (20 mL*3). The combined organic layer was dried over anhydrous NaSO4, and then concentrated to afford the crude product, which was further purified using chromatography on silica gel ( Petroleum ether / EtOAc) to obtain the products 9a-9j., 30459-17-7

The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Li, Shu; Li, Gongming; Yang, Xiaohong; Meng, Qian; Yuan, Shuo; He, Yun; Sun, Dequn; Bioorganic and Medicinal Chemistry Letters; vol. 28; 13; (2018); p. 2275 – 2278;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Octanoic acid (62 ??, 0.39 mmol), HOBt (58 mg, 0.43 mmol), TBTU (138 mg, 0.43 mmol), anhydrous triethylamine (87 ??, 0.63 mmol) and dry DMF (2 ml) were placed in an oven-dried Schlenk tube under a nitrogen atmosphere. The resulting solution was stirred at room temperature for 15 minutes. A second Schlenk tube was prepared containing 1-(4-trifluoromethyl phenyl) piperazine (100 mg, 0.43 mmol and dry DMF (1 ml) under a nitrogen atmosphere. The resulting solution was stirred until complete dissolution of the piperazine had occurred. The piperazine solution was then transferred, via a cannula, to the first Schlenk tube containing the carboxylic acid. The resulting solution was stirred for 24 hrs, under nitrogen, and monitored by TLC. After 24 hrs, the DMF was removed under reduced pressure and the resulting oil was acidified using a 0.1 M hydrochloric acid solution. The aqueous mixture was extracted with dichloromethane (20 ml, followed by 4 x 10 ml) and the organic layer washed with a saturated sodium bicarbonate solution (3 x 20 ml) and brine (3 x 20 ml). The organic layer was dried over magnesium sulphate and evaporated under reduced pressure. The residue was purified using flash chromatography (3:2, EtOAc:n-hexane) to obtain the desired product in an 63 % yield. H NMR (300 MHz, CDCI3) ? 7.48 (d, 2H), 6.91 (d, 2H), 3.77 (t, 2H), 3.62 (t, 2H), 3.24-3.30 (m, 4H), 2.34 (t, 2H), 1.61-1.71 (m, 2H), 1 .29-1.34 (m, 8H), 0.86-0.91 (m, 3H). MS (+ESI) calcd for C19 H27 F3 N2 O m/z: [M + H]+ , 357.2148; found 357.2136 [Diff(ppm) = -3.36].

30459-17-7, The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NATIONAL UNIVERSITY OF IRELAND, MAYNOOTH; STEPHENS, John; FINDLAY, John; KINSELLA, Gemma; MARTIN, Darren; DEVINE, Robert; VELASCO-TORRIJOS, Trinidad; WO2013/60860; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-[Trans-4-(4-trifluoromethylsulfanyl-phenylamino)-cyclohexyloxy]-acetic acid (18 mg, 0.05 mmol, prepared in accordance with Example 30) and 2-(1H-benzotriazol-1-yl)- 1,1,3,3-tetramethyluronium hexafluorophosphate (19 mg, 0.05 mmol) were dissolved in dry tetrahydrofuran (2 mL) and stirred at room temperature for 10 min. 1-(4- Trifluormethyl-phenyl)-piperazine (12 mg, 0.05 mmol) and diisopropylethylamine (18 muL, 0.10 mmol) were then added, and the solution was stirred at room temperature for 1.5 hr. Aluminium oxide was then added (1 spatula). Afterward, the mixture was diluted with diethylether (10 mL) and filtered. The filtrate was concentrated under vacuum. The crude product was purified by preparative etaPLC. Following lyophilization of the fractions of interest, the desired product was isolated as a solid (16 mg, 57% yield). The structure was confirmed using Protocol I-B. Calculated mass = 562; observed mass = 562; etaPLC retention time = 6.03 min.

30459-17-7, 30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; INTERVET INTERNATIONAL B.V.; WO2009/77527; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Synthesisof compounds (1-18) has been carriedout according to the procedure previously standardized in our laboratory with severalmodifications.1 Briefly, an equimolar mixture (0.01 mol) of 1-fluoro-4-nitrobenzeneand respective alkyl /heteroaryl/ aryl substituted piperazinein 30 ml of dried dimethylformamide (DMF)/ dried dimethylsulfoxide (DMSO) was stirredat room temperature for 4-8 h. Reaction completion was monitored by TLC andreaction mixture diluted with water (40 ml). Product has been extracted withchloroform and dried over anhydrous sodium sulphate. The chloroform was thenevaporated under reduced pressure to give pure 1-(4-nitro phenyl)-4-substituedpiperazine derivatives (1-18)., 30459-17-7

As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference£º
Article; Kumari, Shikha; Mishra, Chandra Bhushan; Tiwari, Manisha; Bioorganic and Medicinal Chemistry Letters; vol. 25; 5; (2015); p. 1092 – 1099;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 77 (2-Cyclohex-1-enyl-5-methanesulfonyl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone Following procedure E, (2-Cyclohex-1-enyl-5-methanesulfonyl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone is prepared from 2-cyclohex-1-enyl-5-methanesulfonyl-benzoic acid (Example G) 1-(4-trifluoromethyl-phenyl)-piperazine: colourless solid, MS (ISP): 493.2 (M+H+).

30459-17-7, 30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Alberati-Giani, Daniela; Jolidon, Synese; Narquizian, Robert; Nettekoven, Matthias Heinrich; Norcross, Roger David; Pinard, Emmanuel; Stalder, Henri; US2005/59668; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: To a mixture of 6a-p (1.0mmol) and K2CO3 in acetone (10mL) was added 6-(bromomethyl)-5-chloro-2-(thiophen-2-yl)-7,8-dihydroquinoline 5 (1mmol) at room temperature under stirring for 12h (monitored by TLC), After completion the reaction mixture was evaporated and extracted with ethylacetate and water, the organic layer was separated dried over anhydrous Na2SO4. and evaporated under vacuum. The resulting crude product was purified by silica gel column chromatography by using EtOAc/hexane as eluent.

30459-17-7, 30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Marvadi, Sandeep Kumar; Krishna, Vagolu Siva; Sriram, Dharmarajan; Kantevari, Srinivas; European Journal of Medicinal Chemistry; vol. 164; (2019); p. 171 – 178;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: At first, THF (2.0 mL) was added to a mixture of oxabenzonorbornadiene 1 (0.347 mmol, 1.0 equiv), amine 4 or 6 (1.041 mmol, 3.0 equiv), NaI (10.34 mg, 0.069 mmol, 0.2 equiv), ligand L2 (4.5 mg, 0.0167 mmol, 4.8 mol %) and [Rh(C2H4)2Cl]2 (2.7 mg, 0.0069 mmol, 2.0 mol %) under N2. The mixture was then stirred at RT for 1 h and heated at reflux for 6-12 h after which the residue was subjected directly to silica gel column chromatography [ethylacetate/hexanes (1:1-2:1 v/v) as the eluent] to afford the desired alcohol product 5 or 7. The enantioselectivity was determined by chiral HPLC on a chiralcel OD-H, chiralcel AD-H, or Lux Amylose-2 column.

30459-17-7, 30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Luo, Renshi; Xie, Ling; Liao, Jianhua; Xin, Hu; Chan, Albert S.C.; Tetrahedron Asymmetry; vol. 25; 9; (2014); p. 709 – 717;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics