Category: 30459-17-7

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of carboxylic acid (50 mmol) in DMF (0.25 mL) in a 48 position Mettler Toledo XT reaction block was added PyBOP (50 mmol, 0.2 mL of 0.3 M solution in DMF) and TEA (75 mmol, 0.05 mL of 1.5 M solution in DMF) followed by the appropriate amine build blocks (55 mmol, 0.55 ml of 1 M solution in DMF). The reactions were stirred at rt 24 h and concentrated by GeneVac HT-4 to remove all reaction mixture including excess amine and DMF. The crude mixtures were dissolved in EtOAc (1 mL) and filtered through silica-packed short-column and washed with EtOAc (3 mL). The collected organic solution was concentrated in GeneVac HT-4 and dissolved in DMSO (1 mL). DMSO solution was subjected to HTAC for pre-purification analysis, purification, and final QC., 30459-17-7

30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference：
Article; Hwang, Jong Yeon; Attia, Ramy R.; Carrillo, Angela K.; Connelly, Michele C.; Guy, R. Kiplin; Bioorganic and Medicinal Chemistry Letters; vol. 23; 6; (2013); p. 1891 – 1895;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 2-chloro-4-(trifluoromethyl)-benzonitrile (1.00 mmol), appropriate amine (NR2, 2.00 mmol),and DBU (2.5 mmol) were dissolved in 1,4-dioxane (8 ml). Themixture was stirred for 12 h at 50 C. The reaction was quenched with water and extracted with EtOAc twice. The combined organicextracts were dried over MgSO4, filtered, and concentrated invacuo. The residue was purified by flash column chromatographyon silica gel using EtOAc/hexane (1:7-1:10) eluant condition.(NR2 = 4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine hydrochloridefor 17).

30459-17-7, 30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference：
Article; Ann, Jihyae; Jung, Aeran; Kim, Mi-Yeon; Kim, Hyuk-Min; Ryu, Hyungchul; Kim, Sunjoo; Kang, Dong Wook; Hong, Sunhye; Cui, Minghua; Choi, Sun; Blumberg, Peter M.; Frank-Foltyn, Robert; Bahrenberg, Gregor; Stockhausen, Hannelore; Christoph, Thomas; Lee, Jeewoo; Bioorganic and Medicinal Chemistry; vol. 23; 21; (2015); p. 6844 – 6854;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a stirred solution of oxirane (0.17mmol) in methanol (5 mL) was added the appropriate secondary amines (0.17mmol).Then the reaction mixture was refluxed for 24 h. After completion, the reaction mixture was allowed to room temperature the resulting crude was concentrated under reduced pressure and purified by column chromatography to yield the corresponding beta-amino alcohol derivatives., 30459-17-7

As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference：
Article; Vanguru, Sowmya; Jilla, Lavanya; Sajja, Yasodakrishna; Bantu, Rajashaker; Nagarapu, Lingaiah; Nanubolu, Jagadeesh Babu; Bhaskar, Bala; Jain, Nishant; Sivan, Sreekanth; Manga, Vijjulatha; Bioorganic and Medicinal Chemistry Letters; vol. 27; 4; (2017); p. 792 – 796;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-Oxo-4-(2-thienyl) butyric acid (63 mg, 0.34 mmol), HOBt (58 mg, 0.43 mmol), TBTU (140 mg, 0.43 mmol), anhydrous triethylamine (0.1 ml, 0.69 mmol) and dry DMF (2 ml) were placed in an oven- dried Schlenk tube under a nitrogen atmosphere. The resulting solution was stirred at room temperature for 15 minutes. A second Schlenk tube was prepared containing 1-(4-trifluoromethyl phenyl) piperazine (100 mg, 0.43 mmol) and dry DMF (1 ml) under a nitrogen atmosphere. The resulting solution was stirred until complete dissolution of the piperazine had occurred. The piperazine solution was then transferred, via a cannula, to the first Schlenk tube containing the carboxylic acid. The resulting solution was stirred for 24 hrs, under nitrogen, and monitored by TLC. After 24 hrs, the DMF was removed under reduced pressure and the resulting oil was acidified using a 0.1 M hydrochloric acid solution. The aqueous mixture was extracted with dichloromethane (20 ml, followed by 4 x 10 ml) and the organic layer washed with a saturated sodium bicarbonate solution (3 x 20 ml) and brine (3 x 20 ml). The organic layer was dried over magnesium sulphate and evaporated under reduced pressure. The residue was purified using flash chromatography (3:2, EtOAc:n-hexane) to obtain the desired product in an 81 % yield. H NMR (300 MHz, CDCI3) ? 7.81 (d, 1 H), 7.63 (d, 1 H), 7.49 (d, 2H), 7.13-7.16 (m, 1 H), 6.92 (d, 2H), 3.72-3.81 (m, 4H), 3.28 (t, 4H), 3.25 (t, 2H), 2.81 (t, 2H). MS (+ESI) calcd for C19 H19 F3 N2 02 S m/z: [M + H]+ , 396.1 1 15; found 396.1 1 19 [Diff(ppm) = -1.1 1].

30459-17-7, As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference：
Patent; NATIONAL UNIVERSITY OF IRELAND, MAYNOOTH; STEPHENS, John; FINDLAY, John; KINSELLA, Gemma; MARTIN, Darren; DEVINE, Robert; VELASCO-TORRIJOS, Trinidad; WO2013/60860; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-Oxo-4-(2-thienyl) butyric acid (63 mg, 0.34 mmol), HOBt (58 mg, 0.43 mmol), TBTU (140 mg, 0.43 mmol), anhydrous triethylamine (0.1 ml, 0.69 mmol) and dry DMF (2 ml) were placed in an oven- dried Schlenk tube under a nitrogen atmosphere. The resulting solution was stirred at room temperature for 15 minutes. A second Schlenk tube was prepared containing 1-(4-trifluoromethyl phenyl) piperazine (100 mg, 0.43 mmol) and dry DMF (1 ml) under a nitrogen atmosphere. The resulting solution was stirred until complete dissolution of the piperazine had occurred. The piperazine solution was then transferred, via a cannula, to the first Schlenk tube containing the carboxylic acid. The resulting solution was stirred for 24 hrs, under nitrogen, and monitored by TLC. After 24 hrs, the DMF was removed under reduced pressure and the resulting oil was acidified using a 0.1 M hydrochloric acid solution. The aqueous mixture was extracted with dichloromethane (20 ml, followed by 4 x 10 ml) and the organic layer washed with a saturated sodium bicarbonate solution (3 x 20 ml) and brine (3 x 20 ml). The organic layer was dried over magnesium sulphate and evaporated under reduced pressure. The residue was purified using flash chromatography (3:2, EtOAc:n-hexane) to obtain the desired product in an 81 % yield. H NMR (300 MHz, CDCI3) ? 7.81 (d, 1 H), 7.63 (d, 1 H), 7.49 (d, 2H), 7.13-7.16 (m, 1 H), 6.92 (d, 2H), 3.72-3.81 (m, 4H), 3.28 (t, 4H), 3.25 (t, 2H), 2.81 (t, 2H). MS (+ESI) calcd for C19 H19 F3 N2 02 S m/z: [M + H]+ , 396.1 1 15; found 396.1 1 19 [Diff(ppm) = -1.1 1].

30459-17-7, As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference：
Patent; NATIONAL UNIVERSITY OF IRELAND, MAYNOOTH; STEPHENS, John; FINDLAY, John; KINSELLA, Gemma; MARTIN, Darren; DEVINE, Robert; VELASCO-TORRIJOS, Trinidad; WO2013/60860; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of substituted piperazine (10 mmol), 4-uoroben-zaldehyde (10 mmol) and K2CO3 (2 mmol) were reuxed at130 C in DMF for 15-24 h. Thereafter, the reaction mixture waspoured into ice cold water and the precipitate that appeared wasltered and dried to accomplish formyl derivatives (14-25) in ayield of 80-90%, 30459-17-7

As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference£º
Article; Mishra, Chandra Bhushan; Manral, Apra; Kumari, Shikha; Saini, Vikas; Tiwari, Manisha; Bioorganic and Medicinal Chemistry; vol. 24; 16; (2016); p. 3829 – 3841;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 15 Preparation of (2S)-(-)-1-(4-indolyloxy)-3-(4-(4-trifluoromethylphenyl)piperazin-1-yl)-2-propanol ethanedioate The title compound was prepared in similar fashion from (S)-(+)-4-(oxiranylmethoxy)-1H-indole and 1-(4-trifluoromethylphenyl)piperazine. The resulting free base was dissolved in ethyl acetate, and precipitated with one equivalent of oxalic acid in ethyl acetate in 89% overall yield. FDMS m/e=419 (M+ of free base)., 30459-17-7

As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference£º
Patent; Eli Lilly Company; US5789402; (1998); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

To a solution of 10 (100 mg, 0.33 mmol) and 1-(4-trifluoromethylphenyl)piperazine (85 mg,0.37 mmol) in DMF (0.5 mL) was added solid K2CO3 (82 mg, 0.59 mmol). The resulting suspensionwas stirred at 90 C for 48 h. Water (5 mL) and DCM (5 mL) were added and the phases were separated.The aqueous phase was then extracted with further DCM (2 5 mL). The organics were dried over anh.Na2SO4, filtered and evaporated in vacuo to give a yellowish solid (161 mg). Column chromatography(hexane/EtOAc mixture) gave 15 as a white solid (52 mg, 32% yield). The analytical sample wasobtained by washing with cooled pentane (38 mg), m.p. 157-158 C. IR (ATR) : 667, 711, 721, 744,770, 806, 824, 909, 951, 971, 984, 1039, 1070, 1106, 1157, 1199, 1230, 1330, 1354, 1390, 1429, 1493, 1522,1594, 1615, 2847, 2919 cm1. 1H-NMR (400 MHz, CDCl3) : 0.10-0.18 (complex signal, 2H, 9-H2),0.84-0.98 (complex signal, 2H, 8-H and 10-H), 2.54-2.66 (complex signal, 2H, 2-H and 6-H), 2.75 (m, 1H,1-H or 7-H), 2.90 (m, 1H, 7-H or 1-H), 3.26 (m, 1H, 3-Ha or 5-Ha), 3.41 [t, J = 5.4 Hz, 4H, 2?(6?)-H2],3.48 (m, 1H, 5-Ha or 3-Ha), 3.56-3.82 [complex signal, 6H, 3-Hb, 5-Hb, 3?(5?)-H2], 5.69 (m, 1H, 11-Hor 12-H), 5.85 (m, 1H, 12-H or 11-H), 6.65 (d, J = 8.8 Hz, 1H, 50-H), 6.95 [d, J = 8.6 Hz, 2H, 2??(6??)-H],7.50 [d, J = 8.6 Hz, 2H, 3??(5??)-H], 7.66 (dd, J = 8.8 Hz, J? = 2.2 Hz, 1H, 40-H), 8.31 (d, J = 2.2 Hz, 1H,20-H). 13C-NMR (100.5 MHz, CDCl3) : 3.9 (CH2, C9), 10.2 (broad s, CH, C8 and C10), 35.6 (CH, C1and C7), 42.7 (CH, C2 or C6), 44.5 [CH2, C3?(5?)], 45.1 (CH, C6 or C2), 47.7 [CH2, C2?(6?)], 49.6 (CH2,C3 or C5), 53.6 (CH2, C5 or C3), 105.8 (CH, C50), 114.6 [CH, C2??(6??)], 120.8 (q, J = 32 Hz, C, C4??),122.1 (C, C30), 124.6 (q, J = 269 Hz, C, CF3), 126.4 [q, J = 4 Hz, CH, C3??(5??)], 128.1 (CH, C11 or C12),129.3 (CH, C12 or C11), 137.5 (CH, C40), 147.5 (CH, C20), 153.0 (C, C1??), 159.1 (C, C60), 167.0 (C, CO).HRMS-ESI + m/z [M + H]+ calcd. for [C28H29F3N4O + H]+: 495.2396, found: 495.23692.

30459-17-7, The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Leiva, Rosana; McBride, Andrew; Binnie, Margaret; Webster, Scott P.; Vazquez, Santiago; Molecules; vol. 23; 3; (2018);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of the compound from example 11 (100 mg, 0.33 mmol) and 1-(4- trifluoromethylphenyl)piperazine (85 mg, 0.37 mmol) in DMF (0.5 mL) was added solid K2C03 (82 mg, 0.59 mmol). The resulting suspension was stirred at 90 C for 48 hours. Water (5 mL) and DCM (5 mL) were added and the phases were separated. Theaqueous phase was then extracted with further DCM (2 x 5 mL). The organics were dried over anh. Na2SO4, filtered and evaporated in vacuo to give a yellowish solid (161 mg). Column chromatography (Hexane/Ethyl acetate mixture) gave the title compound as a white solid (52 mg, 31.9% yield). The analytical sample was obtained by washing with cooled pentane (38 mg), m. p. 157-158 C. JR (ATR) v: 667, 711, 721, 744, 770,806, 824, 909, 951, 971, 984, 139, 1070, 1106, 1157, 1199, 1230, 1330, 1354, 1390,1429, 1493, 1522, 1594, 1615, 2847, 2919 cm1. Accurate mass: Calculated for [C28H29F2N4O+H]: 475.2294. Found: 475.2366.

30459-17-7, The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CIDQO 2012, S.L.; UNIVERSITAT DE BARCELONA; VAZQUEZ CRUZ, Santiago; LEIVA MARTINEZ, Rosana; VALVERDE MURILLO, Elena; (60 pag.)WO2017/182464; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 26 To a solution of Compound B (0.2 g, 0.54 mmol) in acetonitrile (5 mL) at room temperature were added diisopropylethylamine (0.4 mL, 2.3 mmol) and 1-(4-trifluoromethylphenyl)piperazine (0.187 g, 0.81 mmol) and the reaction mixture was heated to 80 C. On heating, the reaction mixture became clear and after 15 min commencement of precipitation of solid was observed. Heating was continued for 3 hr and then the reaction mixture was cooled. The solid obtained was collected by filtration, washed with acetonitrile and dried under vacuum. LC/MS: (M+H)+: 565. An NMR spectrum is provided in FIG. 26.Yield: 0.22 g (72%).

30459-17-7, The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sudhakar, Anantha; US2011/105497; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics