Category: 30459-17-7

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: To a solution of acid chloride 3a-b (1.0 equiv.), triethylamine (3.0 equiv.) in dry THF, was added arylpiperazines (1.2 equiv.) in dry THF dropwise. The mixture was stirred for 1 h at room temperature. The reaction mixture was diluted with EtOAc, washed with water and brine, dried over anhydrous MgSO4, and concentrated in vacuo. The crude product was purified by flash column chromatography on silica gel (EtOAC:hexanes = 1:1-1:5) to yield the desired products (4a-j). Compound 4d: 1H NMR (300 MHz, CDCl3) delta 7.52 (d, J = 8.6 Hz, 2H), 6.95 (d, J = 8.6 Hz, 2H), 3.92 (m, 4H), 3.37 (s, 4H), 3.03 (m, 2H), 2.56 (m, 1H), 2.35 (m, 1H), 2.13 (m, 1H), 1.34 (m, 2H), 0.96 (s, 9H).

30459-17-7, The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Song, Jiho; Lee, Kiho; Kim, Doran; Kim, Jongmin; Lee, Seul; Shin, Jun Seob; Kim, Dong-Seok; Min, Kyung Hoon; Bulletin of the Korean Chemical Society; vol. 35; 2; (2014); p. 666 – 668;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of carboxylic acid 6 (3.5 mol), EDC*HCl (5.4 mol), HOBt (5.4 mol) in anhydrous DMF (20 mL) was stirred at RT. Substituted piperazine (3.5 mol) was then added and the mixture was further stirred at RT for 10-12 hr40. After completion of the reaction as indicated by TLC, the reaction mixture was quenched in crushed ice. The precipitated solid was washed with NaHCO3 and dil. HCl. The product thus obtained was purified by silica gel column chromatography using hexane: ethyl acetate as eluent., 30459-17-7

The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Raundal, Hemant N.; Jadhav, Rahul P.; Patil, Amar A.; Bobade, Vivek D.; Indian Journal of Chemistry – Section B Organic and Medicinal Chemistry; vol. 54B; 8; (2015); p. 979 – 987;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: The appropriate 1-substituted piperazines (1 mmol)and Et3N (3 mmol) were added to a solution of 6-chloropurines(1mmol) (5, 6) in 5 mL of absolute EtOH. Themixture was refluxed for 8-16 h. The reaction mixture wasconcentrated in vacuo and the residue was purified by columnchromatography (EtOAC-hexane, 1:3 to 1:1).

30459-17-7, The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Atalay, Rengul Cetin; Guven, Ebru Bilget; Kucukdumlu, Asligul; Tuncbilek, Meral; Acta Chimica Slovenica; vol. 67; 1; (2020); p. 70 – 82;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

To a solution of 9.2 mmol 2-iodo-5-methanesulfonyl-benzoic acid in 20 ml dimethylformamide 11.5 mmol TBTU, 46.0 mmol N-ethyldiisopropylamine and 11.0 mmol 1-(4-trifluoromethylphenyl)piperazine (ABCR F07741NB, [30459-17-7])were successively added. The reaction was then stirred at RT for two hours, concentrated in vacuo and purified by column chromatography (SiO2, 50 g, CH2Cl2/MeOH/NH3=100/0/0 to 95/4.5/0.5), to give the title compound 1.9. MS (m/e): 539.1 (M+H+), 30459-17-7

The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Jolidon, Synese J.; Narquizian, Robert; Nettekoven, Matthias Heinrich; Norcross, Roger David; Pinard, Emmanuel; Stalder, Henri; US2005/209241; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: To the chloro compounds (1.00 mmol) in toluene, were added piperazines 8a-j (1.0 mmol) at room temperature. The reaction mixture was heated at 110 oC for overnight. After completion (TLC), the reaction mixture was extracted with ethyl acetate and water. The organic layer was separated and dried over anhydrous Na2SO4, evaporated to dryness. The residue was purified with column chromatography using an eluent of 25% ethyl acetate in hexane to furnish the compounds with moderate to good yields (64-82%).

30459-17-7, As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference：
Article; Banu, Saleha; Bollu, Rajitha; Naseema, Mohammad; Gomedhika, P. Mary; Nagarapu, Lingaiah; Sirisha; Kumar, C. Ganesh; Gundasw, Shravan Kumar; Bioorganic and Medicinal Chemistry Letters; vol. 28; 7; (2018); p. 1166 – 1170;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

To a solution of 0.32 mmol 5-cyano-2-isopropylsulfanyl-benzoic acid in 5 ml tetrahydrofuran were added successively 0.31 mmol TBTU, 0.84 mmol N-ethyldiisopropylamine and 0.22 mmol 1-(4-trifluoromethylphenyl)-piperazine (commercially available, e.g. from Fluorochem). The reaction mixture was stirred at 35 C. for 16 h and then concentrated in vacuo. Chromatography (SiO2, ethyl acetate/heptane) followed by trituration in pentane afforded the title compound as an off-white solid (yield 94%). MS (m/e): 434.4 (M+H+, 100%)., 30459-17-7

As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference：
Patent; Jolidon, Synese; Narquizian, Robert; Norcross, Roger David; Pinard, Emmanuel; US2006/149062; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The crude acid chloride 7 obtained in the previous step was cooledto 0 C and dissolved in dry DMF (2 mL). To this solution, the appropriateamine (1.65 mmol) and triethylamine (1 mL, 10 mmol) wereadded. The reaction mixture was stirred at 100 C for 6 h. The solutionwas poured over crushed ice and the precipitated solid was filtered off,washed with water, dried and recrystallized from the suitable solvent. Yield: 65%, m.p.: 120-122?C, I.R (KBr, cm-1): upsilonmax 3464 (NH), 3116 (CH aromatic), 2924 (CH aliphatic), 1670 (2C=O), 1635 (C=N), 1550 (C=C), 1H NMR: delta 3.35 (s, 8H, piperazinyl-H), 4.37 (s, 2H, CH2), 7.18-7.24 (m, 2H, trifluorophenyl-H), 7.37-7.45 (m, 6H, trifluorophenyl-H and phenyl-H), 7.87-7.90 (m, 1H, pyridyl-H), 8.40 (d, 1H, J?=?8.2?Hz, pyridyl-H), 9.05 (d, 1H, J?=?3.5?Hz, pyridyl-H), 12.86 (s, 1H, NH exchanged by D2O). Anal. Calcd. for C26H22F3N5O2 (493.49): C, 63.28; H, 4.49; N, 14.19. Found: C, 63.56; H, 4.65; N, 14.53.

30459-17-7, The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Elmasry, Ghada F.; Aly, Enayat E.; Awadallah, Fadi M.; El-Moghazy, Samir M.; Bioorganic Chemistry; vol. 87; (2019); p. 655 – 666;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-(4-Trifluormethyl-phenyl)-piperazine (283 mg, 1 mmol) and triethylamine (220 muL, 2 mmol) were dissolved in dichloromethane (8 mL). Chloroacetyl chloride (110 muL, 1 mmol) was then slowly added under stirring. After stirring for an additional 10 min at room temperature, the mixture was diluted with dichloromethane (10 mL), washed with water (10 mL), and washed with saturated aqueous sodium hydrogencarbonate (10 mL). The organic layer was collected, dried over magnesium sulfate, filtered, and concentrated under vacuum. The desired product was isolated as a light yellow oil (292 mg, 95% yield).

30459-17-7, The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; INTERVET INTERNATIONAL B.V.; WO2009/77527; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: Arylpiperazines (1.2 equiv) and potassium carbonate (4.0equiv) were added to a solution of 1 (1 equiv) in acetonitrile(CH3CN, 20 mL). The reaction mixture was heated to 85 Cand stirred for 12 h. Afterward the mixture was cooled toroom temperature. The reaction mixture was filtered, and thefiltrate was concentrated in vacuo. The residue was extractedwith ethyl acetate (60 mL) and water (20 mL). After dryingthe organic layer with anhydrous Na2SO4and evaporatingthe solvent under reduced pressure, a solid was appeared.The solid was recyrstallized from ethanol to obtain intermediates2.

30459-17-7, As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference：
Article; Chen, Hong; Jia, Huixia; Qian, Yuna; Shen, Jianliang; Yu, Yuzhong; Zhang, Haibo; Zhao, Shanchao; Pharmacological Reports; (2020);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The mixture of intermediate 2 (267 mg, 1.0 mmol), co-responding amines and Zn(ClO4)2. 6H2O (7.4 mg, 2.0 mol %) in dichloromethane (5 mL) was stirred at room temperature under argon. After completion of the reaction, the mixture was diluted with water and extracted with dichloromethane(3×30 mL). The combined dichloromethane was dried over anhydrous sodium sulfate and solvent was removed under reduced pressure to give target compounds 6a-n (Table 2) which were purified by column chromatography eluting with chloroform : methanol., 30459-17-7

30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference：
Article; Van Chinh, Luu; Anh, Le Duc; Nga, Nguyen Thi; Ly, Nguyen Thi Hai; Ha, Vu Thi; Toan, Tran Quoc; Cuong, Nguyen Manh; Vu, Tran Khac; Letters in Organic Chemistry; vol. 14; 8; (2017); p. 603 – 611;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics