Category: 30459-17-7

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To solution of compound 3 (1 equiv) in 20 ml of ACN,NaI (1.2 equiv) was added and the mixture was refluxed for 30 min and cooled to room temperature. Subsequently,K2CO3 (1.2 equiv) and appropriate phenylpiperazine derivative(1.2 equiv) were added. Then the mixture was refluxedfor 4h. At the end of this period, the mixture was evaporatedto dryness then the product was solidified with ice-cold waterand crystallized from appropriate solvent.

30459-17-7, As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference：
Article; Kilic, Burcu; Erdogan, Merve; Gulcan, Hayrettin O.; Aksakal, Fatma; Oruklu, Nihan; Bagriacik, Emin U.; Dogruer, Deniz S.; Medicinal Chemistry; vol. 15; 1; (2019); p. 59 – 76;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1- (4- (trifluoromethyl) phenyl) piperazine (A-1, 43.7 mg, 0.19 mmol),1-((4-cyanophenyl) amino) cyclopentyl-1-carboxylic acid (B-1, 40.0 mg, 0.17 mmol), anhydrous triethylamine (35.4 mg, 0.35 mmol) was dissolved in 5 mL of anhydrous acetonitrile And anhydrous DMF in 1mL,Add 2- (7-benzotriazole) -N, N, N ?, N?-tetramethylurea hexafluorophosphate (HATU) (68.4mg, 0.18mmol), and react at room temperature for 30min. After the reaction, it was diluted with water and extracted with ethyl acetate. The organic layer was washed with dilute hydrochloric acid, sodium bicarbonate solution, and saturated brine in that order. The organic layer was dried over anhydrous sodium sulfate, filtered, and concentrated. The concentrate was subjected to silica gel column chromatography (PE: EA = 2: 1, v / v) separation to obtain solid 1, yield 95.5%, 30459-17-7

As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference：
Patent; Hangzhou Weitan Pharmaceutical Technology Co., Ltd.; Cheng Yunfeng; Hu Yongzhou; (45 pag.)CN110357833; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: 2,6-Dichloro-9-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-9H-purine (24) (447 mg, 1 mmol) was dissolved in 5 mL absolute EtOH, then 1-(alpha,alpha,alpha-trifluoro-p-tolyl)piperazine (0.23g, 1 mmol)/ 2-(1-cyclohexenyl) ethylamine (0.125g, 1 mmol) and (Et)3N (3 equiv) were added. The mixture was refluxed for 10-12 h. The reaction mixture was concentrated in vacuo and the residue was purified by column chromatography. 2-Chloro-6-[4-(4-trifluoromethylphenyl)piperazine-1-yl]-9-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-9H-purine (25) The compound was prepared from (24) and 1-(4-trifluoromethylphenyl)piperazine according to the general procedure and was purified by column chromatography (EtOAc-hexane, 1:2) to yield 25 as viscous oil (850 mg; 75%). 1H NMR (CDCl3) delta 2.0 (s, 3H, CH3), 2.02 (s, 3H, CH3), 2.09 (s, 3H, CH3), 3.44 (br s, 4H, piperazine CH2), 3.94-4.72 (m, 7H, H-4?, CH2-5?, piperazine CH2), 5.55 (t, 1H, H-3?), 5.86 (t, 1H, H-2?), 6.16 (d, 1H, H-1?), 7.09 (d, J = 8.8 Hz, 2H, H-2,6 in phenyl), 7.50 (d, J = 8.4 Hz, 2H, H-3,5 in phenyl), 8.43 (s, 1H, H-8). MS (ESI+) m/e: 641.9 (%100) (M+H), 643.9 (%48) (M+H+2).

30459-17-7, 30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference：
Article; Tuncbilek, Meral; Kucukdumlu, Asl?gul; Guven, Ebru Bilget; Altiparmak, Duygu; Cetin-Atalay, Rengul; Bioorganic and Medicinal Chemistry Letters; vol. 28; 3; (2018); p. 235 – 239;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Compounds 1a-l and compounds 15-19 were synthesized in the same reaction: In a dichloromethane solution (2-3 mL) of chloroacetylchloride(1.1 eq), a dichloromethane solution (8-10 mL) of the appropriate piperazine (1 eq) and triethylamine (2.5 eq) was added dropwise and the reaction mixture was stirred overnight at room temperature under a nitrogen atmosphere. The reaction mixture was evaporated and the residue was extracted with ethylacetate-brine. The organic layer was dried over Na2SO4 and chromatographed on silica preparative TLC to give the desired products.When the reaction was run for 2 h, compounds 1a-l were the mainproducts (>90%).

30459-17-7, As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference：
Article; Papadopoulou, Maria V.; Bloomer, William D.; Rosenzweig, Howard S.; O’Shea, Ivan P.; Wilkinson, Shane R.; Kaiser, Marcel; European Journal of Medicinal Chemistry; vol. 103; (2015); p. 325 – 334;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 5-methyl-3-isoxazole-4-carbonyl chloride (1.19g, 5.37mmol) in dioxane (15ml, anhydrous) was added dropwise to a cooled mixture (0C) containing l-(4-trifluoro- methylphenyl)-piperazine (1.24g, 5.38mmol commercially available) and pyridine (0.81ml, O.Olmol) in dioxane (25ml, anhydrous). The reaction solution was allowed to attain ambient temperature. Water was added to the solution affording a precipitation that was isolated by filtration. Re-crystallization from a mixture of MeOH/Acetonitrile (2: 1) afforded white crystalline compound (1.74g, 75%). 1H-NMR (400 MHz, DMSO-d6) delta 7.61-7.60 (m, 2H), 7.49-51 (m, 5H), 7.01-6.99 (m, 2H), 3.75 (br, 2H), 3.32 (br, 4H), 2.94 (br, 2H), 2.48 (s, 3H). 13C-NMR (400 MHz, DMSO-d6) delta 169.6(s), 162.4(s), 160.5(s), 153.6(s), 131.0(d), 129.8(d, 2H), 129.1(s), 128.2(d, 2C), 127.0 (q, 4JCF = 3.7 Hz, CCF3, 2C), 125.8 (q, lJ CF = 270.1 Hz, CCF3), 119.6 (q, 2JCF = 32.0 Hz, CCF3),115.4(d, 2C), 112.0(s), 48.0 (t, 4CH2), 12.1(q).

30459-17-7, The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; VIRONOVA AB; HOMMAN, Mohammed; KINGI, Ngarita; BERGMAN, Jan; ENGQVIST, Robert; WO2013/171334; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Synthesis of new compounds 1-4 and 7-9 was performed bynucleophilic substitution (alkylation of amines) following theprocedure previously reported with certain modifications [43].Briefly, the corresponding ferrocene haloalkane (1.0 mmol), thesubstituted amine (1.0 mmol) and K2CO3 or NaH (2.0 mmol) weredissolved in THF (20 mL). The reaction was stirred at room temperatureuntil TLC (CH2Cl2/methanol or hexane/ethyl acetate)proved that the reaction did not go (about 48 h). THF was removedand the residue was diluted in CH2Cl2. The organic phase waswashed with water, dried over anhydrous Na2SO4, filtered, andevaporated. The residue obtained was purified either by automatedflash chromatography, eluting in gradient with CH2Cl2/methanol, orby precipitation with cold diethyl ether. Compounds 5 and 6 werepreviously characterized and evaluated as antibacterial agents [48].So, the general procedure for their synthesis was followed asdescribed by Damljanovic et al. with slight modifications [48]. Amixture of i3 (1.0 mmol), the corresponding amine (1.5 mmol) andMontmorillonite K10 (100 mg) was irradiated by microwave (50W,1.5 min). TLC was used to follow the reaction. The crude wasextracted with CH2Cl2 and evaporated on the rotary evaporator. Theresidue obtained was purified by automated flash chromatography,eluting in gradient with hexane/ethyl acetate. The final compoundwas precipitated with cold diethyl ether in order to obtain an orangepowder.

30459-17-7, The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Paucar, Rocio; Martin-Escolano, Ruben; Moreno-Viguri, Elsa; Cirauqui, Nuria; Rodrigues, Carlos Rangel; Marin, Clotilde; Sanchez-Moreno, Manuel; Perez-Silanes, Silvia; Ravera, Mauro; Gabano, Elisabetta; European Journal of Medicinal Chemistry; vol. 163; (2019); p. 569 – 582;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,30459-17-7

General procedure: A solution of arylpiperazine (5.5 mmol) and triethylamine (0.8 mL;5.5 mmol) in anhydrous THF (20 mL) was added dropwise to a stirredsolution of an appropriate alkyl [2-/3-(bromoacetyl)phenyl]carbamate(5.5 mmol) in anhydrous THF (30 mL), and the mixture stirred for 3 h atambient temperature. The solvents were removed under reduced pressure,and added chloroform (100 mL) and water. The organic phase waswashed with additional water, dried over anhydrous sodium sulfate andthe solvent removed under reduced pressure, to give a solid crudeproduct, which was recrystallized from acetone.

The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Campos, Ludmila E.; Garibotto, Francisco M.; Angelina, Emilio; Kos, Jiri; Toma?i?, Tihomir; Zidar, Nace; Kikelj, Danijel; Gonec; Marvanova, Pavlina; Mokry, Petr; Jampilek; Alvarez, Sergio E.; Enriz, Ricardo D.; Bioorganic Chemistry; vol. 91; (2019);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,30459-17-7

Dark brown solid; IR (KBr, cm-1): v 3282 (-NH), 3068-3076 (-CH str.), 2223 (CN), 1256 (C-O-C), 833 (s-triazine C-N str.), 749 (C-F). 1H NMR (400 MHz, Me2SO-d6): delta 9.18 (s, 1H, -NH, s-triazine to amino-benzonitrile linkage), 8.10 (d, J = 7.4 Hz, 1H, C8 proton of quinoline), 7.77 (t, J = 7.6 Hz, 1H, C7 proton of quinoline), 7.59 (d, J = 8.6 Hz, 1H, C5 proton of quinoline), 7.52 (t, J = 7.2 Hz, 1H, C6 proton of quinoline), 7.39 (s, 1H, C3 proton of quinoline), 7.26-6.93 (7H, m, Ar-H), 3.89 (4H, br s, piperazine), 3.77 (s, 3H, N-CH3), 3.51 (4H, br s, piperazine). 13C NMR (100 MHz, Me2SO-d6): delta 175.8 (1C, C-6, s-triazine, C-N at piperazine linkage), 167.5 (1C, C-4, s-triazine, C-O-C at quinoline linkage), 165.5, 163.6 (2C, 1C at C-2, s-triazine, C-NH at benzonitrile moiety and 1C of CO), 144.8-116.7 (22C, Ar. C including 2C-CF3 at 129.9, 130.4 and 2CF3 at 125.2, 125.7), 105.9 (1C, CN), 95.8 (1C, -C-CN), 48.2, 45.6 (4C, piperazine ring carbon atoms), 30.6 (1C, N-CH3). 19F NMR (400 MHz, CDCl3): delta -66.03, -63.29 (6F, s, -CF3 of piperazine moiety and -CF3 of amino benzonitrile moiety).

30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference：
Article; Patel, Rahul V.; Kumari, Premlata; Rajani, Dhanji. P.; Chikhalia, Kishor H.; Journal of Fluorine Chemistry; vol. 132; 9; (2011); p. 617 – 627;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The mixture of Pd2(dba)3 (377 mg, 0.410 mmol), piperidine (500 mg, 5.87 mmol), t-BuOK (851 mg, 7.58 mmol), X-Phos (418 mg, 0.877 mmol) and intermediate M-2 (1000 mg, 3.35 mmol) in toluene (40 mL) was heated under a nitrogen atmosphere at 110 C until complete by TLC. Upon completion, the reaction solution was cooled to ambient temperature, concentrated under vacuum, and purified by flash chromatography (3:1 petroleum ether: ethyl acetate eluent) to yield N-(2,6-dimethyl-4-(piperidin-1-yl)phenyl)-3,3-dimethylbutanamide (293mg, 29% yield)., 30459-17-7

As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference：
Article; Yang, Shaoning; Lu, Dingqiang; Ouyang, Pingkai; Bioorganic and Medicinal Chemistry Letters; vol. 28; 10; (2018); p. 1731 – 1735;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

In a 25 mL round bottom flask was added 100 mg (0.22 mmol) of Intermediate 4, 59.8 mg (0.26 mmol) of 1-(4-trifluoromethylphenyl)piperazine, 182 mg (1.32 mmol) of potassium carbonate, 15 mL of acetonitrile,The reaction was carried out at 86[deg.] C. for 16 h. TLC showed that the starting material was completely reacted. Stop the reaction, filter, and concentrate. The crude product was purified by column chromatography on silica gel, eluent: V (ethyl acetate): V (petroleum ether) = 1:3 to give 35.2 mg of a white solid. Yield: 33%.

30459-17-7, The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Yuan Mu; Chen Hong; Ye Bibo; Yang Zonglin; (17 pag.)CN107573302; (2018); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics