Category: 30459-17-7

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Stepl: To a solution of 1 (0.31 g, 1.43 mmol) in THF (20 mL) was added Ti(OEt)4 (0.595 g, 2.58 mmol) and N-(4-trifluoromethylphenyl)-piperazine 2 (0.3 g, 1.3 mmol). The mixture was stirred at 40’C for 24h, quenched by adding ice- water, extracted with ethyl acetate (3 x 20 mL), dried. Purification by column chromatography (PE/EA:1/1) gave product 3 (0.25 g, 41%)., 30459-17-7

30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; COGNITION THERAPEUTICS, INC.; CATALANO, Susan, M.; RISHTON, Gilbert; IZZO, Nicholas, J.; WO2013/29057; (2013); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

Yellow solid; IR (KBr, cm-1): v 3284 (-NH), 3069-3078 (-CH str.), 2223 (CN), 1255 (C-O-C), 836 (s-triazine C-N str.), 749 (C-F). 1H NMR (400 MHz, Me2SO-d6): delta 9.22 (s, 1H, -NH, s-triazine to amino-benzonitrile linkage), 8.10 (dd, J = 1.7, 1.1 Hz, 1H, C5 proton of coumarin), 7.61-7.64 (m, 1H, coumarin), 7.45 (t, J = 8.5 Hz, 1H, C6 proton of coumarin), 7.33-36 (m, 1H, coumarin), 7.29-6.90 (9H, m, Ar-H), 3.87 (4H, br s, piperazine), 3.48 (4H, br s, piperazine). 13C NMR (100 MHz, Me2SO-d6): delta 175.4 (1C, C-6, s-triazine, C-N at piperazine linkage), 167.2 (1C, C-4, s-triazine, C-O-C at quinoline linkage), 165.9, 163.8 (2C, 1C at C-2, s-triazine, C-NH at benzonitrile moiety and 1C of CO), 152.9 (1C of C-9, coumarin), 148.3-119.6 (19C, Ar. C including C-CF3 at 129.7 and CF3 at 126.1), 106.1 (1C, CN), 97.4 (1C, -C-CN), 48.6, 46.2 (4C, piperazine ring carbon atoms). 19F NMR (400 MHz, CDCl3): delta -65.33 (3F, s, 4-CF3)., 30459-17-7

30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Patel, Rahul V.; Kumari, Premlata; Rajani, Dhanji. P.; Chikhalia, Kishor H.; Journal of Fluorine Chemistry; vol. 132; 9; (2011); p. 617 – 627;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: In a flask chargedwith 50 mL of CH3CNwas added 2.5mmol of compound6 and appropriate piperazine derivatives (3a-w, 1.5 eq.) and thereaction mixturewas refluxed for 10-38 h until the complete consumptionof starting material as detected by TLC. After the completion of thereaction, the reaction mixture was treated with ice and the resultingsolid was filtered and washed with water (2 ¡Á 25 mL). The residuewas purified with a silica gel column chromatography and was elutedwith dichloromethane: methanol (40:1) to afford corresponding products7a-w in 49-82% of yields, 30459-17-7

30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Patel, Rahul V.; Mistry, Bhupendra; Syed, Riyaz; Rathi, Anuj K.; Lee, Yoo-Jung; Sung, Jung-Suk; Shinf, Han-Seung; Keum, Young-Soo; European Journal of Pharmaceutical Sciences; vol. 88; (2016); p. 166 – 177;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: Compound 6 (1mmol) was dissolved in freshly distilled dichloromethane (5mL) under nitrogen atmosphere. Then HOBt (1.1mmol), EDC,HCl (1.1mmol) were added to it. The reaction mixture was stirred for 5min, secondary amine 7a-l (1.2mmol) was added in a slow stream and followed by the addition of triethylamine (2mmol) and the reaction mixture was stirred for 24hat room temperature. The progress of the reaction was monitored by TLC. After completion of the reaction, water (10mL) was added to the reaction mixture and extracted with dichloromethane. Organic layer was collected and dried over anhydrous Na2SO4. After filtration, the solvent was removed under reduced pressure and the crude product was purified by silica gel chromatography using an eluent of 50% ethyl acetate in hexane., 30459-17-7

The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Banu, Saleha; Bollu, Rajitha; Bantu, Rajashaker; Nagarapu, Lingaiah; Polepalli, Sowjanya; Jain, Nishant; Vangala, Radhika; Manga, Vijjulatha; European Journal of Medicinal Chemistry; vol. 125; (2017); p. 400 – 410;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: Compound 6 (1mmol) was dissolved in freshly distilled dichloromethane (5mL) under nitrogen atmosphere. Then HOBt (1.1mmol), EDC,HCl (1.1mmol) were added to it. The reaction mixture was stirred for 5min, secondary amine 7a-l (1.2mmol) was added in a slow stream and followed by the addition of triethylamine (2mmol) and the reaction mixture was stirred for 24hat room temperature. The progress of the reaction was monitored by TLC. After completion of the reaction, water (10mL) was added to the reaction mixture and extracted with dichloromethane. Organic layer was collected and dried over anhydrous Na2SO4. After filtration, the solvent was removed under reduced pressure and the crude product was purified by silica gel chromatography using an eluent of 50% ethyl acetate in hexane., 30459-17-7

The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Banu, Saleha; Bollu, Rajitha; Bantu, Rajashaker; Nagarapu, Lingaiah; Polepalli, Sowjanya; Jain, Nishant; Vangala, Radhika; Manga, Vijjulatha; European Journal of Medicinal Chemistry; vol. 125; (2017); p. 400 – 410;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Amine 15 (hydrochloride) (4.3 mmol) was dissolved in CH2Cl2 (5 ml), and the solution was cooled with an ice bath. A solution of ethyl chloroglyoxylate (4.7 mmol) in CH2Cl2 (2 ml) was added dropwise, and the mixture was stirred at 0C for 0.5-1 hour. The reaction solution was diluted with ethyl acetate. The organic layer was washed with an aqueous saturated sodium chloride solution and dried with anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain crude product. This crude product was dissolved in ethanol (13 ml), 2 mol/L sodium hydroxide (6.5 ml 13 mmol) was added, and the mixture was stirred at room temperature for 1.5 hour. The solvent was distilled off under reduced pressure, and 2 mol/L hydrochloric acid was added to the residue to acidic, and the precipitated crystal was collected by filtration. The crystal was washed with water and dried to obtain carboxylic acid 16 (yield 77-99%). To carboxylic acid 16 (1.0 mmol) were added DMF (10 ml), aniline (1.2 mmol), HOBt (1.2 mmol), triethylamine (1.2 mmol), DMAP (0.05 mmol) and WSCD¡¤HCl (1.2 mmol). The mixture was stirred at room temperature for overnight. An aqueous saturated sodium bicarbonate solution was added, and the aqueous layer was extracted with EtOAc. The organic layer was washed with brine, dried over MgSO4, and concentrated under reduced pressure. The residue was purified by amino silica gel column chromatography (CHCl3/MeOH, gradient: 0-10% MeOH) to afford oxamide 6a-v (yield 46-91%).

30459-17-7, 30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Anan, Kosuke; Masui, Moriyasu; Tazawa, Aya; Tomida, Minoru; Haga, Yoshihiro; Kume, Masaharu; Yamamoto, Shoichi; Shinohara, Shunji; Tsuji, Hiroki; Shimada, Shinji; Yagi, Shigenori; Hasebe, Nobuyoshi; Kai, Hiroyuki; Bioorganic and Medicinal Chemistry Letters; vol. 29; 9; (2019); p. 1143 – 1147;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5-(Thiophen-2-yl)pentanoic acid (72 mg, 0.39 mmol), HOBt (58 mg, 0.43 mmol), TBTU (138 mg, 0.43 mmol), anhydrous triethylamine (86 ??, 0.62 mmol) and dry DMF (2 ml) were placed in an oven-dried Schlenk tube under a nitrogen atmosphere. The resulting solution was stirred at room temperature for 15 minutes. A second Schlenk tube was prepared containing 1-(4-trifluoromethyl phenyl) piperazine (100 mg, 0.43 mmol) and dry DMF (1 ml) under a nitrogen atmosphere. The resulting solution was stirred until complete dissolution of the piperazine had occurred. The piperazine solution was then transferred, via a cannula, to the first Schlenk tube containing the carboxylic acid. The resulting solution was stirred for 24 hrs, under nitrogen, and monitored by TLC. After 24 hrs, the DMF was removed under reduced pressure and the resulting oil was acidified using a 0.1 M hydrochloric acid solution. The aqueous mixture was extracted with dichloromethane (20 ml, followed by 4 x 10 ml) and the organic layer washed with a saturated sodium bicarbonate solution (3 x 20 ml) and brine (3 x 20 ml). The organic layer was dried over magnesium sulphate and evaporated under reduced pressure. The residue was purified using flash chromatography (3:2, EtOAc:n-hexane) to obtain the desired product in an 25 % yield. H NMR (300 MHz, CDCI3) ? 7.49 (d, 2H), 7.09 (dd, 1 H), 6.89-7.01 (m, 3H), 6.79-6.84 (m, 1 H), 3.76 (t, 2H), 3.59 (t, 2H), 3.23 (t, 4H), 2.85 (t, 2H), 2.37, (t, 2H), 1.74-1.82 (m, 4H). MS (+ESI) calcd for C20 H23 F3 N2 O m/z: [M + H]+ , 396.1468; found 397.1556 [Diff(ppm) = -3.75]., 30459-17-7

30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; NATIONAL UNIVERSITY OF IRELAND, MAYNOOTH; STEPHENS, John; FINDLAY, John; KINSELLA, Gemma; MARTIN, Darren; DEVINE, Robert; VELASCO-TORRIJOS, Trinidad; WO2013/60860; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-Thienylacetic acid (54 mg, 0.39 mmol), HOBt (58 mg, 0.43 mmol), TBTU (138 mg, 0.43 mmol), anhydrous triethylamine (87 ??, 0.63 mmol) and dry DMF (2 ml) were placed in an oven-dried Schlenk tube under a nitrogen atmosphere. The resulting solution was stirred at room temperature for 15 minutes. A second Schlenk tube was prepared containing 1-(4-trifluoromethyl phenyl) piperazine (100 mg, 0.43 mmol and dry DMF (1 ml) under a nitrogen atmosphere. The resulting solution was stirred until complete dissolution of the piperazine had occurred. The piperazine solution was then transferred, via a cannula, to the first Schlenk tube containing the carboxylic acid. The resulting solution was stirred for 24 hrs, under nitrogen, and monitored by TLC. After 24 hrs, the DMF was removed under reduced pressure and the resulting oil was acidified using a 0.1 M hydrochloric acid solution. The aqueous mixture was extracted with dichloromethane (20 ml, followed by 4 x 10 ml) and the organic layer washed with a saturated sodium bicarbonate solution (3 x 20 ml) and brine (3 x 20 ml). The organic layer was dried over magnesium sulphate and evaporated under reduced pressure. The residue was purified using flash chromatography (3:2, EtOAc:n-hexane) to obtain the desired product in an 20 % yield. H NMR (300 MHz, CDCI3) ? 7.47 (d, 2H), 7.19 (dd, 1 H), 6.88-6.97 (m, 4H), 3.96 (s, 2H), 3.79 (t, 2H), 3.66 (t, 2H), 3.24 (t, 2H), 3.15 (t, 2H). MS (+ESI) calcd for C17 H17 F3 N2 02 S m/z: [M + H]+ , 355.1086; found 355.1084 [Diff(ppm) = -0.56].

30459-17-7, As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference£º
Patent; NATIONAL UNIVERSITY OF IRELAND, MAYNOOTH; STEPHENS, John; FINDLAY, John; KINSELLA, Gemma; MARTIN, Darren; DEVINE, Robert; VELASCO-TORRIJOS, Trinidad; WO2013/60860; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

4-(Thiophen-2-yl)butanoic acid (0.05 ml, 0.34 mmol), HOBt (58 mg, 0.43 mmol), TBTU (140 mg, 0.43 mmol), anhydrous triethylamine (0.1 ml, 0.69 mmol) and dry DMF (2 ml) were placed in an oven-dried Schlenk tube under a nitrogen atmosphere. The resulting solution was stirred at room temperature for 15 minutes. A second Schlenk tube was prepared containing 1-(4-trifluoromethyl phenyl) piperazine (100 mg, 0.43 mmol) and dry DMF (1 ml) under a nitrogen atmosphere. The resulting solution was stirred until complete dissolution of the piperazine had occurred. The piperazine solution was then transferred, via a cannula, to the first Schlenk tube containing the carboxylic acid. The resulting solution was stirred for 24 hrs, under nitrogen, and monitored by TLC. After 24 hrs, the DMF was removed under reduced pressure and the resulting oil was acidified using a 0.1 M hydrochloric acid solution. The aqueous mixture was extracted with dichloromethane (20 ml, followed by 4 x 10 ml) and the organic layer washed with a saturated sodium bicarbonate solution (3 x 20 ml) and brine (3 x 20 ml). The organic layer was dried over magnesium sulphate and evaporated under reduced pressure. The residue was purified using flash chromatography (3:2, EtOAc:n-hexane) to obtain the desired product in an 80% yield. H NMR (300 MHz, CDCI3) ? 7.49 (d, 2H), 7.12 (dd, 1 H), 6.90-6.94 (m, 3H), 6.80-6.82 (m, 1 H), 3.76 (t, 2H), 3.56 (t, 2H), 3.24 (t, 4H), 2.91 (t, 2H), 2.38 (t, 2H), 2.0-2.1 1 (m, 2H). MS (+ESI) calcd for C18 H21 F3 N2 O S m/z: [M + H]+, 382.1329; found 383.1399 [Diff(ppm) = 0.61]., 30459-17-7

The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NATIONAL UNIVERSITY OF IRELAND, MAYNOOTH; STEPHENS, John; FINDLAY, John; KINSELLA, Gemma; MARTIN, Darren; DEVINE, Robert; VELASCO-TORRIJOS, Trinidad; WO2013/60860; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

30459-17-7, Methyl hydrogen azelate (479 mg, 2.3 mmol), BOP (1 .14 g, 2.6 mmol), anhydrous triethylamine (512 [it, 3.6 mmol) and anhydrous DCM (40 mL) were placed in an oven-dried three neck flask under a nitrogen atmosphere. The resulting solution was stirred at room temperature for 15 minutes. 1-(4- (Trifluoromethyl)phenyl)piperazine (600 mg, 2.6 mmol) was added and the reaction mixture stirred under nitrogen and monitored by TLC. After 16 hours, the DCM was removed under reduced pressure and the resulting oil was acidified using a 0.1 M HCI. The aqueous mixture was extracted with DCM (20 mL, followed by 4 x 10 mL) and the organic layer washed with a saturated sodium bicarbonate solution (3 x 20 mL) and brine (3 x 20 mL). The organic layer was dried over magnesium sulphate and the solvent removed in vacuo. The residue was purified using flash chromatography (3:2, EtOAc et. Ether) to obtain the desired product as an off white solid in a 98% yield. H NMR (300 MHz, CDCI3) ? 7.41 (d, J = 8.7 Hz, 2H), 6.85 (d, J = 8.7 Hz, 2H), 3.73-3.69 (m, 2H), 3.58 (overlapping -OCH3 and piperazine -CH2 signal, m, 5H), 3.23-3.19 (m, 4H), 2.28 (t, J = 7.8 Hz, 2H), 2.21 (t, J = 7.8 Hz, 2H), 1.58-1.56 (m, 4H), 1.30-1.26 (m, 6H). 3C NMR (75 MHz, CDCI3) 174.2, 171 .7, 152.9, 126.4 (q, J = 3.75 Hz), 120.6 (q, J = 33 Hz), 1 19.2 (q, J = 271.5 Hz), 1 14.9, 51.4, 48.4, 48.1 , 45.1 , 41.1 , 34.0, 33.2, 29.2, 29.0, 28.9, 25.1 , 24.8. MS (+ESI) calcd for C2i H29 F3 N2 03 m/z: [M + H]+, 415.2203; found 415.219 [Diff(ppm) = -3.14].

The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NATIONAL UNIVERSITY OF IRELAND, MAYNOOTH; STEPHENS, John; FINDLAY, John; KINSELLA, Gemma; MARTIN, Darren; DEVINE, Robert; VELASCO-TORRIJOS, Trinidad; WO2013/60860; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics