Category: 300543-56-0

In an article, author is Ang, Micah Belle Marie Yap, once mentioned the application of 300543-56-0, Name is (R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine, molecular formula is C17H19ClN2, molecular weight is 286.8, MDL number is MFCD11519277, category is piperazines. Now introduce a scientific discovery about this category, Recommanded Product: (R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine.

Merits of using cellulose triacetate as a substrate in producing thin-film composite nanofiltration polyamide membranes with ultra-high performance

Choosing the property of the supporting membrane is crucial in preparing high performing nanofiltration membranes through interfacial polymerization. In this study, an oxygen rich membrane – cellulose triacetate (CTA) – was used to fabricate the support membrane. Polyamide was deposited onto the CTA support using interfacial polymerization of piperazine (PIP) and trimesoyl chloride (TMC). The concentration of the monomers was optimized. Furthermore, the polyamide layer prepared on CTA support exhibited higher separation efficiency for sodium sulfates and dyes compared to using traditional polysulfone (PSf) support. The oxygen groups of CTA facilitate better adsorption of amines on the surface; thus, using low concentration of PIP could still provide a defect-free polyamide layer. Utilizing the optimum condition, the polyamide/CTA membrane delivered a high pure water flux (operating at 6 bar) of 179.5 L/m(2)h with the following rejections: Na2SO4 = 98.4%; MgSO4 = 60.3%; MgCl2 = 15.0%; NaCl = 3.7%; Rose Bengal = 95.5%; Brilliant Blue R = 99.9%; Amido Black 10B = 90.6%; Orange G = 67.3%. Moreover, the polyamide/CTA membrane had excellent stability at a wide range operating conditions. (C) 2020 Taiwan Institute of Chemical Engineers. Published by Elsevier B.V. All rights reserved.

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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.300543-56-0, Name is (R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine, SMILES is ClC1=CC=C([C@H](N2CCNCC2)C3=CC=CC=C3)C=C1, belongs to piperazines compound. In a document, author is Shi, S. K., introduce the new discover, Recommanded Product: 300543-56-0.

A Keggin-Type Tungstovanadate-Based Hybrid Compound: Synthesis, Crystal Structure, and Electrocatalytic Oxidation of Ascorbic Acid

A new V-centered Keggin polyoxometalate-based inorganic-organic hybrid (HPpz)(3)[VW12O40] (I) (Ppz = piperazine) has been hydrothermal synthesized and characterized by IR spectroscopy, UV-Vis spectroscopy, elemental analysis and single-crystal X-ray diffraction (CIF file CCDC no. 1835683). Compound I belongs to the rhombohedral space group R (3) over barc and displays a three-dimensional supramolecular structure. The band gap energy value calculated for compound I was observed to be 1.30 eV using UV-Vis-NIR absorption spectrum. Furthermore, electrocatalytic performance of I has also been investigated in details.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 300543-56-0. Recommanded Product: 300543-56-0.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 300543-56-0, Name is (R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine, formurla is C17H19ClN2. In a document, author is Bari, Darakhshan Gazala, introducing its new discovery. Product Details of 300543-56-0.

SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL EVALUATION OF SOME ARYL PIPERAZINE COMPOUNDS

In this planed research work, aryl piperazine derivatives will be synthesized because aryl piperazine currently the most important constructive block in drug discovery with positive pharmacological evaluation. A series N- (4-(benzo[d]thiazol-2-yl) phenyl)-2-[4-(arylsubstituted) piperazines-1-yllacetamide, N-(4-(benzo[d]oxazol-2-yl)phenyl)2-[4-(arylsubstituted)piperazines-1-yl]acetamide and Synthesis of N-(4(benzo[d]imidazol-2-yl) phenyl)- 2- (4-(arylsubstituted)piperazin-1-yl) acetamide will be synthesized with their characterization such as melting point determination, Thin-layer chromatography (TLC) and spectral analysis. After that, pharmacological evaluation, such as antibacterial activity, will be performed for synthesized compounds. All the synthesized compounds were reported for determination of zone of inhibition (mm), minimum inhibitory concentrations (MIC) were also calculated for effective derivatives, with an objective to offer some potent antimicrobial agents to human beings. Antimicrobial activity is determined based on their in-vitro activity in pure cultures. In-vitro susceptibility testing is done by two methods i.e.. Turbidimetric/photometric/tube dilution method and agar diffusion/cupplat/cylinder plate method.

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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.300543-56-0,(R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine,as a common compound, the synthetic route is as follows.

A mixture containing (4-chlorophenyl)phenyl methylamine free base (4.1 g, 18.8 mmol), N,N-bis(2-chloroethyl)benzyl carbamate (7 g, 26.7 mmol) potassium iodide (1.7 g, 10 mmol) and diisopropyl ethylamine (10 ml) was stirred at 135 C. (oil bath), for 4 hours.While cooling down, 60 ml dichloromethane was added. The mixture was stirred at ambient temperature for 20 min. 35 ml HCl (1M) was added to the dichloromethane. The organic layer was separated, washed with NaCl (10 ml) dried and concentrated to give an oily material (10 g). The impure material was purified with AcOEt/heptane column (3?50%).0.5 grams of above pure material was dissolved in a solution containing 1.3 g NaOH in 1.2 ml H2O and 5 ml 2-propanol. The mixture was heated til 100 C. for 5 h. The mixture was concentrated in vacuo to get rid of 2-propanol and redissolved in 10 ml toluene and 5 ml H2O. The mixture was stirred for 20 min and layers were separated. The organic layer was dried over Na2SO4 and concentrated. To the crude product ethyl acetate (10 ml) was added, followed by addition of 0.2 g oxalic acid dissolved in 1 ml EtOH. The suspension was stirred 4 h at ambient temperature and overnight at 5 C. The solid obtained was filtered off and dried at air to give a solid material (0.3 g, 38.5% yield). 98.86% ee purity.

300543-56-0, 300543-56-0 (R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine 668697, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Zhu, Jie; US2009/143582; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.300543-56-0,(R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine,as a common compound, the synthetic route is as follows.

Example 2a) [2- [4- [ (4-chlorophenyl)phenylmethyl] -1-piperazinil] ethoxy] – acetonitrile dihydrochlorideCharge 2400 mL of acetonitrile to the reaction vessel, add 400 g of (-) -1- [ (4-chlorophenyl) phenylmethyl ] -4-piperazine, 300 g Na2CO3, 20 g KI and 300 g of 2- (2-chloroethoxy) acetonitrile in turn under stirring.Stir and gradually raise the temperature to 110-115 0C. Keep the temperature for 20 hours, after the reaction is completed, cool the mixture to 80-90 0C and add 25 g of activated carbon and stir for 20 minutes. Filter off carbon and wash cake with appropriate amount of acetonitrile. Into combined filtrate in? troduce dry HCl gas until pH value reaches 0.5-1. Continue to stir the slurry for 20 minutes and filter. Wash the cake with appropriate amount of ethanol and dry at 50-550C for 10 hours to obtain 520 g of the title product.The yield 95%, HPLC (area) 95 %. The obtained [2- [4- [(4- chlorophenyl) phenylmethyl] -1-piperazinyl] ethoxy] -acetonitrile dihydrochloride has in the X-ray powder diffractogram the peaks at about: 8.5; 18.5; 19.1; 22.7; 24.9; 25.7; 25.9 in 28.7 +/- 0.2 2Theta.b) Maceration of a crude [2- [4- [ (4-chlorophenyl)phenylmethyl] – 1-piperazinyl] ethoxy] -acetonitrile dihydrochloride10 g of [2- [4- [ (4-chlorophenyl) phenylmethyl] -1-piperazinyl] ethoxy] -acetonitrile dihydrochloride were suspended in 30 mL of methanol. The suspension was heated to the boiling tempera? ture and stirred at this temperature for at least 20 minutes. Thereafter the suspension was cooled to 0 0C and stirred at this temperature for one hour. The precipitate was filtered, washed with cold methanol and dried. HPLC (area) 98 %., 300543-56-0

As the paragraph descriping shows that 300543-56-0 is playing an increasingly important role.

Reference£º
Patent; KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO; WO2008/110586; (2008); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics