Category: 288251-87-6piperazines

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.288251-87-6,tert-Butyl 4-(2-cyano-4-nitrophenyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.,288251-87-6

To a stirred solution of 567 tert-butyl 4-(2-cyano-4-nitrophenyl)piperazine-1-carboxylate (2.0 g, 6.021 mmol, 1.0 eq) in 6 EtOH (30 mL) was added Fe(0) (1.0 g, 18.064 mmol, 3 eq) and a solution of 67 NH4Cl (644 mg, 12.042 mmol, 2 eq) in 7 water (30 mL) at rt. The resulting mixture was heated at 90 C. for 1 hr. The progress of reaction was monitored by LCMS. The reaction mixture was filtered through celite the residue was washed with EtOH (50 mL). The filtrate was concentrated and the residue was dissolved in 19 EtOAc (100 mL), washed with water (2¡Á100 mL), dried over Na2SO4, and concentrated to afford the desired compound, 570 tert-butyl 4-(4-amino-2-cyanophenyl)piperazine-1-carboxylate (1.77 g, 88.5%). (0598) LCMS: 303.2 [M+1]+

As the paragraph descriping shows that 288251-87-6 is playing an increasingly important role.

Reference£º
Patent; giraFpharma LLC; Chakravarty, Sarvajit; PHAM, Son Minh; Kankanala, Jayakanth; AGARWAL, Anil Kumar; PUJALA, Brahmam; SONI, Sanjeev; ARYA, Satish K.; PALVE, Deepak; KUMAR, Varun; (360 pag.)US2019/106436; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

288251-87-6, tert-Butyl 4-(2-cyano-4-nitrophenyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-(2-Cyano-4-nitro-phenyl)-piperazine-l -carboxylic acid tert-butyl ester (587 mg, 1.77 mmol) was dissolved in methanol (50 mL) and to this solution was added ammonium chloride (945 mg, 17.66 mmol) and zinc (1155 mg, 17.66 mmol). The mixture was magnetically stirred for 3 hr and the mixture was filtered through a pad of celite. The solids were rinsed with methanol and the combined filtrate was concentrated to a yellow solid. This crude intermediate was dissolved in ethyl acetate (400 mL) and the resulting solution was washed with water (400 mL) and brine (200 mL). The organic layer was collected, dried over sodium sulfate, and concentrated to give 4-(4-amino-2-cyano- phenyl)-piperazine-l-carboxylic acid tert-butyl ester that was used in the next step without further purification., 288251-87-6

The synthetic route of 288251-87-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; WO2008/141976; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics