Category: 2759-28-6piperazines

2759-28-6, 1-Benzylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Amine (1 mmol) and di-tert-butyl dicarbonate [(Boc)2O] (1.1 mmol) were placed in a microwave reaction vial. The LG microwave oven MG 555f was programmed to 300 W at 100 C. The reaction was monitored using TLC. After the reaction, ice water was added to the reaction mixture which resulted in the precipitation of the product. The solid product was merely filtered off and washed with excess cold water. The product was pure enough for all practical purposes. For characterization purpose, it was further purified by column chromatography (Neutral Alumina as adsorbent, solvent system: Hexane: Ethyl acetate (7.5:2.5)).

2759-28-6, The synthetic route of 2759-28-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Dighe, Satish N.; Jadhav, Hemant R.; Tetrahedron Letters; vol. 53; 43; (2012); p. 5803 – 5806;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2759-28-6,1-Benzylpiperazine,as a common compound, the synthetic route is as follows.

Synthesis of 1-(1,1-dimethylethoxycarbonyl)4-phenylmethylpiperazine STR30 A solution of 3.4 g (0.024 mole) of 1,1-dimethylethoxy carbonylazide in 5 ml of pyridine was rapidly added to a stirred solution of 1-phenylmethylpiperazine (4.2 g, 0.024 mole) in 5 ml of pyridine. An initial exothermic reaction was noted. The mixture was allowed to stir overnight, diluted with water and the product was extracted with two 50 ml portions of ether. The ether extracts were dried (MgSO4), filtered, and evaporated to yield a yellow oil. Column chromatography (2″ diameter column, 500 g of silica gel, ether eluent) followed by sublimation at 110/0.5 mm returned 5.7 g (86%) of white solid, m.p. 64-73. The solid was dissolved in 50 ml of ether and cooled to -70. The resultant white solid was filtered off to yield 4.5 g (68%) of product, m.p. 71-3. Calc. for C16 H24 N2 O2 (276.38): C, 69.53; H, 8.75; N, 10.14. Found: C, 69.44; H, 8.82; N, 10.15.

2759-28-6, 2759-28-6 1-Benzylpiperazine 75994, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ICI Americas Inc.; US4247549; (1981); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics