Category: 27561-62-2piperazines

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.27561-62-2,Cyclohexyl(piperazin-1-yl)methanone,as a common compound, the synthetic route is as follows.

General procedure: 10mM sulfochloride hydrochloride was suspendedin 50 ml ethylacetate and 11mM amine component wasadded with stirring. 2.8 ml triethylamine dissolved in 10 ml ethylacetatewas dropped in with stirring and kept stirring overnight atambient temperature. The reaction mixture was extracted threetimes with water, the organic phase was dried over sodium sulfatefiltered, and then evaporated to dryness. For cases in which an oilyproduct was obtained, the residue was treated with diisopropylether., 27561-62-2

As the paragraph descriping shows that 27561-62-2 is playing an increasingly important role.

Reference£º
Article; Singh, Vinayak; Pacitto, Angela; Donini, Stefano; Ferraris, Davide M.; Boros, Sandor; Illyes, Eszter; Szokol, Balint; Rizzi, Menico; Blundell, Tom L.; Ascher, David B.; Pato, Janos; Mizrahi, Valerie; European Journal of Medicinal Chemistry; vol. 174; (2019); p. 309 – 329;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.27561-62-2,Cyclohexyl(piperazin-1-yl)methanone,as a common compound, the synthetic route is as follows.

TO 4- (3-PIPERIDIN-1-YLPROPOXY) BENZOYL CHLORIDE HYDROCHLORIDE (D3) (0.24g) in DCM (10 ML) was added 1- (CYCLOHEXANECARBONYL)-PIPERAZINE (0.155 g) and diethylaminomethyl polystyrene (3. 2MMOL/G, 0.69g). The mixture was stirred for 16h. The reaction mixture was then loaded directly onto a silica column and eluted with 0-10% MEOH (containing 10% 0.880 ammonia solution) in DCM. The isolated free base was dissolved in DCM (5ML) and treated with 4N HCI/DIOXANE solution (1 ml) with stirring for 10MIN. The reaction was concentrated, and the residue co-evaporated with toluene (3X10M1) and then dried at 50C under high vacuum for 16h to yield the title compound (E57) as a PALE SOLID (0.165G). MS ELECTROSPRAY (+ION) -442 (MH+). 1H NMR 8 (DMSO-D6): 9.71 (S, 1H), 7.39 (d, 2H, J=6.84Hz), 7.00 (d, 2H, J=6.84Hz), 4.10 (m, 2H), 3.47-3. 25 (m, 10H), 3.16 (m, 2H), 2.90 (m, 2H), 2.55 (m, 1H), 2.19 (m, 2H), 1.82-1. 62 (m, 10H), 1.40-1. 16 (m, 6H).

27561-62-2, As the paragraph descriping shows that 27561-62-2 is playing an increasingly important role.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2004/37800; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics