Category: 259808-67-8piperazines

259808-67-8, 1-Boc-3,3-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

20.1: 3,3-Dimethyl-4-(1-phenyl-1H-[1,2,4]triazole-3-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester A mixture of 420 mg (2.22 mmol) 1-phenyl-1H-[1,2,4]-triazole-3-carboxylic acid, 500 mg (2.22 mmol) 3,3-dimethyl-piperazine-1-carboxylic acid tert-butyl ester, 750 mg (2.22 mmol) TBTU and 500 muL (2.91 mmol) DIPEA in 5 mL DMF was stirred at RT for 2 h. The reaction mixture was poured into ice water. The precipitate was filtered off, taken up in EtOAc, dried over sodium sulfate, filtered and concentrated in vacuo. yield: 850 mg (99%) ESI-MS: m/z=386 (M+H)- Rt(HPLC): 1.20 min (method 23), 259808-67-8

259808-67-8 1-Boc-3,3-Dimethylpiperazine 22710387, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; HEIMANN, Annekatrin; DAHMANN, Georg; GRUNDL, Marc; MUELLER, Stephan Georg; WELLENZOHN, Bernd; US2013/158042; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.259808-67-8,1-Boc-3,3-Dimethylpiperazine,as a common compound, the synthetic route is as follows.

Intermediate 20: l-Cyclopropylmethyl-lH-[l ,2,4]triazole-3-carboxylic acid 20.1 : 3,3-Dimethyl-4-(l -phenyl- 1Eta-[ 1 ,2,4]triazole-3-carbonyl)-piperazine- 1 -carboxylic acid tert-butyl ester A mixture of 420 mg (2.22 mmol) l-phenyl-lH-[l ,2,4]triazole-3-carboxylic acid, 500 mg (2.22 mmol) 3,3-dimethyl-piperazine-l-carboxylic acid tert-butyl ester, 750 mg (2.22 mmol) TBTU and 500 mu (2.91 mmol) DIPEA in 5 mL DMF was stirred at RT for 2 h. The reaction mixture was poured into ice water. The precipitate was filtered off, taken up in EtOAc, dried over sodium sulfate, filtered and concentrated in vacuo. yield: 850 mg (99 %) ESI-MS: m/z = 386 (M+H)~ Rt(HPLC): 1.20 min (method 23), 259808-67-8

The synthetic route of 259808-67-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HEIMANN, Annekatrin; DAHMANN, Georg; GRUNDL, Marc; MUELLER, Stephan Georg; WELLENZOHN, Bernd; WO2013/87805; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.259808-67-8,1-Boc-3,3-Dimethylpiperazine,as a common compound, the synthetic route is as follows.

Intermediate 14 was dissolved in DMF (20 mL). DIPEA (1.021 mL, 5.85 mmol) was added, followed by HOBT (395 mg, 2.92 mmol), EDC (561 mg, 2.92 mmol) and tert-butyl 3,3-dimethylpiperazine-1-carboxylate (587 mg, 2.34 mmol). The reaction mixture was stirred at rt overnight, concentrated under reduced pressure, redissolved in DCM, washed with 1M HCl and sat NaHCO3, dried over MgSO4, filtered and concentrated under reduced pressure. The crude material was purified on preparative HPLC UV using the long high pH shallow gradient method (Mobile phase: 30-50% B; A: H2O with 10 mM NH4CO3 and 0.375% NH4OH v/v, B: CH3CN, 30 min run) on XBridge Prep C18 OBD, 50¡Á250 mm, 10 mum, Waters reverse phase column, giving 412 mg title compound (52.6%) as a solid. 1H NMR (400 MHz, CDCl3) delta ppm 1.22-1.35 (m, 1H) 1.38-1.55 (m, 9H) 1.71 (br. s., 1H) 1.94 (br. s., 1H) 2.47 (br. s., 1H) 2.88 (s, 3H) 2.96 (s, 3H) 3.32-3.59 (m, 4H) 3.65-3.85 (m, 2H) 5.77 (br. s., 1H) 6.16 (br. s., 1H) 7.17 (d, J=8.20 Hz, 2H) 7.75 (d, J=8.20 Hz, 2H); MS m/z 402.21 [M+H]+ (ESI).

259808-67-8, The synthetic route of 259808-67-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; US2010/216812; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics