Category: 24860-46-6

24860-46-6, 2-(2-Oxopiperazin-1-yl)acetic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Palladium (0.161 g, 10% on carbon) was added to a mixture of 2-Oxo-1-piperazineacetic acid (0.497 g, 3.14 mmol) and (2-Oxo-ethyl)-carbamic acid tert-butyl ester (0.503 g, 3.16 mmol) in methanol (6.2 mL) under argon. The flask was evacuated and the reaction placed under a hydrogen atmosphere for 22 h. The reaction was filtered through a Celite -plugged filter frit, washed with methanol and DCM, and concentrated in vacuo to afford crude product which was carried to the next step without purification. ESI-MS m/z 324 (M+Na)+., 24860-46-6

24860-46-6 2-(2-Oxopiperazin-1-yl)acetic acid 23422809, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; VENATORX PHARMACEUTICALS, INC.; BURNS, Christopher, J.; DAIGLE, Denis; LIU, Bin; MCGARRY, Daniel; PEVEAR, Daniel, C.; TROUT, Robert, E. Lee; WO2014/151958; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

24860-46-6, 2-(2-Oxopiperazin-1-yl)acetic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Palladium (0.161 g, 10% on carbon) was added to a mixture of 2-Oxo-1-piperazineacetic acid (0.497 g, 3.14 mmol) and (2-Oxo-ethyl)-carbamic acid tert-butyl ester (0.503 g, 3.16 mmol) in methanol (6.2 mL) under argon. The flask was evacuated and the reaction placed under a hydrogen atmosphere for 22 h. The reaction was filtered through a Celite -plugged filter frit, washed with methanol and DCM, and concentrated in vacuo to afford crude product which was carried to the next step without purification. ESI-MS m/z 324 (M+Na)+., 24860-46-6

24860-46-6 2-(2-Oxopiperazin-1-yl)acetic acid 23422809, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; VENATORX PHARMACEUTICALS, INC.; BURNS, Christopher, J.; DAIGLE, Denis; LIU, Bin; MCGARRY, Daniel; PEVEAR, Daniel, C.; TROUT, Robert, E. Lee; WO2014/151958; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24860-46-6,2-(2-Oxopiperazin-1-yl)acetic acid,as a common compound, the synthetic route is as follows.

EXAMPLE C. PREPARATION OF 2-OXO-1,4-PIPERAZINEDIACETIC ACID; LACTAM OF ETHYLENEDIAMINETRIACETIC ACID. Approximately 40.8 g of 2-oxo-l-piperazineacetic acid, prepared by the procedure of Example B, and 70 g of deionized water were added to a beaker and stirred for several hours with a magnetic stirrer bar. The contents were filtered using a medium glass frit funnel and vacuum. The filtrate and 20.0 g of bromoacetic acid were added to a beaker and stirred till all the bromoacetic acid had dissolved. The pH was adjusted to approximately 7 with 25% sodium hydroxide solution. The temperature was maintained at less than 25 C. during the caustic addition by cooling in an ice-water bath. The ice-water bath was removed and the mix allowed to stir for approximately 4-5 hours at approximately 35 C. while maintaining the pH at about 7 by the periodic addition of 25% sodium hydroxide solution. The reaction mix was allowed to stand for several hours and then concentrated (in vacuo) to a weight of approximately 90-100 g and filtered using a medium glass frit funnel and vacuum. Volatiles were removed (in vacuo) from the filtrate at a temperature of 55-60 C. and the material dried in a vacuum oven at 55-60 C. for several hours. The lactam of ethylenediaminetriacetic acid was confirmed by proton and carbon NMR., 24860-46-6

The synthetic route of 24860-46-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; The Dow Chemical Company; US5342604; (1994); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics