Category: 2343-22-8

Application In Synthesis of 5-Fluoroindoline. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about One-Pot Parallel Synthesis of 5-(Dialkylamino)tetrazoles. Author is Savych, Olena; Kuchkovska, Yuliya O.; Bogolyubsky, Andrey V.; Konovets, Anzhelika I.; Gubina, Kateryna E.; Pipko, Sergey E.; Zhemera, Anton V.; Grishchenko, Alexander V.; Khomenko, Dmytro N.; Brovarets, Volodymyr S.; Doroschuk, Roman; Moroz, Yurii S.; Grygorenko, Oleksandr O..

Two protocols for the combinatorial synthesis of 5-(dialkylamino)tetrazoles were developed. The best success rate (67%) was shown by the method that used primary and secondary amines, 2,2,2-trifluoroethylthiocarbamate, and sodium azide as the starting reagents. The key steps included the formation of unsym. thiourea, subsequent alkylation with 1,3-propane sultone and cyclization with azide anion. A 559-member aminotetrazole library was synthesized by this approach; the overall readily accessible (REAL) chem. space covered by the method exceeded 7 million feasible compounds

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Organometallics called Acceptorless Dehydrogenation of N-Heterocycles and Secondary Alcohols by Ru(II)-NNC Complexes Bearing a Pyrazoyl-indolyl-pyridine Ligand, Author is Wang, Qingfu; Chai, Huining; Yu, Zhengkun, which mentions a compound: 2343-22-8, SMILESS is FC1=CC2=C(NCC2)C=C1, Molecular C8H8FN, Name: 5-Fluoroindoline.

Ru(II) hydride complexes bearing a pyrazolyl-(2-indol-1-yl)-pyridine ligand were synthesized and structurally characterized by NMR anal. and x-ray single crystal crystallog. determinations These complexes efficiently catalyzed acceptorless dehydrogenation of N-heterocycles and secondary alcs., resp., exhibiting highly catalytic activity with a broad substrate scope. The present work established a strategy to construct highly active transition-metal complex catalysts, and provides an atom-economical and environmentally benign protocol for the synthesis of aromatic N-heterocyclic compounds and ketones.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

COA of Formula: C8H8FN. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Synthesis and cytotoxicity evaluation of novel 5-fluorinated indoles. Author is Budovska, Mariana; Krochtova, Kristina; Kuba, Miroslav; Tischlerova, Viera; Mojzis, Jan.

Authors report herein the synthesis of a small 28-membered library of novel 5-fluorinated indole phytoalexins. Target compounds were designed by a structure-based bioisosterism strategy. The newly prepared compounds were screened in vitro for cytotoxic activity against seven human cancer cell lines. The cytotoxic evaluation revealed that the 2′-(3,4-dichlorophenylamino) analog of 5-fluorospirobrassinin was the most active against cancer cell lines without causing toxicity to HUVEC cells. Overall, 5-fluoro analogs of indole phytoalexins did not show improved anti-cancer activity compared to the lead compounds The preliminary structure-activity relationship (SAR) study revealed that placing fluoro substituent at C-5 position of the indole ring is not crucial for inducing cytotoxicity against a cancer cell line.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

COA of Formula: C8H8FN. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Re-Catalyzed Annulations of Weakly Coordinating N-Carbamoyl Indoles/Indolines with Alkynes via C-H/C-N Bond Cleavage.

A rhenium-catalyzed [3+2] annulations of N-carbamoyl indoles with alkynes via C-H/C-N bond cleavage, provided rapid access to fused-ring pyrroloindolone derivs I [R1 = H, 6-F, 7-Br, etc.; R2 = R3 = Ph, 4-MeC6H4, 1-naphthyl, etc.]. For the first time, the weakly coordinating O-directing group was successfully employed in rhenium-catalyzed C-H activation reactions, enabled by the unique catalytic ratio of Re2(CO)10, Me2Zn and ZnCl2. Mechanistic studies revealed that aminozinc species played an important role in the reaction. Based on the mechanistic understanding, a more powerful catalytic ratio of Re2(CO)10, [MeZnNPh2]2 and Zn(OTf)2 was devised and applied successfully in the [4+2] annulations of indolines and alkynes affording pyrroloquinolinone derivs II.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthetic Route of C8H8FN. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Glycosylindoles. XII. 1-β-D-Ribofuranosides of 5- and 6-fluoroindole. Author is Mukhanov, V. I.; Preobrazhenskaya, M. N.; Kostyuchenko, N. P.; Filipenko, T. Ya.; Suvorov, N. N..

5(or 6)-Fluoro-1-(5-O-trityl-D-ribofuranosyl)indolines (I) were obtained by condensation of the appropriate fluoroindoline with 5-O-trityl-D-ribose in boiling absolute alc. Dehydrogenation of I gave the corresponding indole derivatives Acetylation of I (5-fluoro) followed by dehydrogenation gave a mixture of α- and β-anomers of 1-(2,3-di-O-acetyl-5-O-trityl-D-ribofuranosyl)-5-fluoroindole. Analogous results were obtained with I (6-fluoro).

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Levinn, Carolyn M.; Mancuso, Jenna L.; Lutz, Rachel E.; Smith, Haley M.; Hendon, Christopher H.; Pluth, Michael D. published an article about the compound: 5-Fluoroindoline( cas:2343-22-8,SMILESS:FC1=CC2=C(NCC2)C=C1 ).Electric Literature of C8H8FN. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:2343-22-8) through the article.

Hydrogen sulfide (H2S) is an important biomol., and self-immolative thiocarbamates have shown great promise as triggerable H2S donors with suitable analogous control compounds; however, thiocarbamates with electron-deficient payloads are less efficient H2S donors. We report here the synthesis and study of a series of N-methylated esterase-triggered thiocarbamates that block the postulated unproductive deprotonation-based pathway for these compounds The relative reaction profiles for H2S release across a series of electron-rich and electron-poor N-Me aniline payloads are examined exptl. and computationally. We show that thiocarbamate N-methylation does block some side reactivity and increases the H2S release profiles for electron-poor donors. Addnl., we show that isothiocyanate release is not a competitive pathway, and rather that the reduced efficiency of electron-poor donors is likely due to other side reactions.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zhang, Jingyu; Chen, Shiya; Chen, Fangfang; Xu, Wensheng; Deng, Guo-Jun; Gong, Hang researched the compound: 5-Fluoroindoline( cas:2343-22-8 ).HPLC of Formula: 2343-22-8.They published the article 《Dehydrogenation of Nitrogen Heterocycles Using Graphene Oxide as a Versatile Metal-Free Catalyst under Air》 about this compound( cas:2343-22-8 ) in Advanced Synthesis & Catalysis. Keywords: graphene oxide nitrogen heterocycle dehydrogenation catalyst green chem. We’ll tell you more about this compound (cas:2343-22-8).

Graphene oxide (GO) has been developed as an inexpensive, environmental friendly, metal-free carbocatalyst for the dehydrogenation of nitrogen heterocycles. Valuable compounds, such as quinoline, 3,4-dihydroisoquinoline, quinazoline, and indole derivatives, have been successfully used as substrates. The investigation of various oxygen-containing mols. with different conjugated systems indicated that both the oxygen-containing groups and large π-conjugated system in GO sheets are essential for this reaction.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov’t, Research Support, U.S. Gov’t, Non-P.H.S., Journal of the American Chemical Society called Intermolecular Hydroamination of 1,3-Dienes To Generate Homoallylic Amines, Author is Yang, Xiao-Hui; Lu, Alexander; Dong, Vy M., which mentions a compound: 2343-22-8, SMILESS is FC1=CC2=C(NCC2)C=C1, Molecular C8H8FN, Category: piperazines.

Authors report a Rh-catalyzed hydroamination of 1,3-dienes to generate homoallylic amines. The work show-cases the first case of anti-Markovnikov selectivity in the intermol. coupling of amines and 1,3-dienes. By tuning the ligand properties and Bronsted acid additive, it was found that a combination of rac-BINAP and mandelic acid is critical for achieving anti-Markovnikov selectivity.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zhang, Jingyu; Chen, Shiya; Chen, Fangfang; Xu, Wensheng; Deng, Guo-Jun; Gong, Hang researched the compound: 5-Fluoroindoline( cas:2343-22-8 ).HPLC of Formula: 2343-22-8.They published the article 《Dehydrogenation of Nitrogen Heterocycles Using Graphene Oxide as a Versatile Metal-Free Catalyst under Air》 about this compound( cas:2343-22-8 ) in Advanced Synthesis & Catalysis. Keywords: graphene oxide nitrogen heterocycle dehydrogenation catalyst green chem. We’ll tell you more about this compound (cas:2343-22-8).

Graphene oxide (GO) has been developed as an inexpensive, environmental friendly, metal-free carbocatalyst for the dehydrogenation of nitrogen heterocycles. Valuable compounds, such as quinoline, 3,4-dihydroisoquinoline, quinazoline, and indole derivatives, have been successfully used as substrates. The investigation of various oxygen-containing mols. with different conjugated systems indicated that both the oxygen-containing groups and large π-conjugated system in GO sheets are essential for this reaction.

Compound(2343-22-8)HPLC of Formula: 2343-22-8 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(5-Fluoroindoline), if you are interested, you can check out my other related articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov’t, Research Support, U.S. Gov’t, Non-P.H.S., Journal of the American Chemical Society called Intermolecular Hydroamination of 1,3-Dienes To Generate Homoallylic Amines, Author is Yang, Xiao-Hui; Lu, Alexander; Dong, Vy M., which mentions a compound: 2343-22-8, SMILESS is FC1=CC2=C(NCC2)C=C1, Molecular C8H8FN, Category: piperazines.

Authors report a Rh-catalyzed hydroamination of 1,3-dienes to generate homoallylic amines. The work show-cases the first case of anti-Markovnikov selectivity in the intermol. coupling of amines and 1,3-dienes. By tuning the ligand properties and Bronsted acid additive, it was found that a combination of rac-BINAP and mandelic acid is critical for achieving anti-Markovnikov selectivity.

From this literature《Intermolecular Hydroamination of 1,3-Dienes To Generate Homoallylic Amines》,we know some information about this compound(2343-22-8)Category: piperazines, but this is not all information, there are many literatures related to this compound(2343-22-8).

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics