Category: 2343-22-8

Computed Properties of C8H8FN. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Design, synthesis and biological evaluation of novel 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole triazole derivatives as potent TRPV1 antagonists. Author is Li, Jinyu; Nie, Cunbin; Qiao, Yue; Hu, Jing; Li, Qifei; Wang, Qiang; Pu, Xiaohui; Yan, Lin; Qian, Hai.

The design, synthesis, and pharmacol. evaluation of a class of TRPV1 antagonists constructed on 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole as A-region and triazole as B-region I (R = 2-Cl 2,5-Me2, 2-NO2-4-Cl, etc.) have been reported. The SAR anal. indicated that 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole analogs I displayed excellent antagonism of hTRPV1 activation by capsaicin and showed better potency compared to the corresponding dihydroindole analogs. Optimization of this design led to the eventual identification of compound I (R = 2-CF3), a potent TRPV1 antagonist. In vitro, using cells expressing recombinant human TRPV1 channels, I (R = 2-CF3) displayed potent antagonism activated by capsaicin (IC 50 = 0.075 μM) and only partially blocked acid activation of TRPV1. In vivo, I (R = 2-CF3) exhibited good efficacy in capsaicin-induced and heat-induced pain models and had almost no hyperthermia side-effect. Furthermore, pharmacokinetic studies revealed that compound I (R = 2-CF3) had a superior oral exposure after oral administration in rats. To understand its binding interactions with the receptor, the docking study of I (R = 2-CF3) was performed in rTRPV1 model and showed an excellent fit to the binding site. On the basis of its superior profiles, I (R = 2-CF3) could be considered as the lead candidate for the further development of antinociceptive drugs.

Compound(2343-22-8)Computed Properties of C8H8FN received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(5-Fluoroindoline), if you are interested, you can check out my other related articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Formula: C8H8FN. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Palladium-Catalyzed Remote 1,n-Arylamination of Unactivated Terminal Alkenes. Author is Han, Chunhua; Fu, Zhiyuan; Guo, Songjin; Fang, Xinxin; Lin, Aijun; Yao, Hequan.

A palladium-catalyzed remote 1,n-arylamination (from 1,3- to 1,11-arylamination) of unactivated terminal alkenes with aryl iodides and arylamines has been realized. This three-component reaction proceeded via Pd-catalyzed Heck arylation, alkene isomerization, and aza-Michael addition, exhibiting good regio- and chemoselectivity, and wide substrate scope. Preliminary mechanistic studies indicated that the in situ generated ortho/para-quinone methide intermediates served as the driving force for the alkene isomerization and promoted the rearomatization upon nucleophilic amination.

Compound(2343-22-8)Formula: C8H8FN received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(5-Fluoroindoline), if you are interested, you can check out my other related articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Fluoroindoline( cas:2343-22-8 ) is researched.Quality Control of 5-Fluoroindoline.Pang, Shaofeng; Liu, Fangfang; Zhang, Yujing; Dong, Zhaowen; Su, Qiong; Wang, Wenfang; Li, Zhenhua; Zhou, Feng; Wang, Yanbin published the article 《Construction of Functional Superhydrophobic Biochars as Hydrogen Transfer Catalysts for Dehydrogenation of N-Heterocycles》 about this compound( cas:2343-22-8 ) in ACS Sustainable Chemistry & Engineering. Keywords: construction functional superhydrophobic biochars hydrogen transfer catalyst dehydrogenation nitrogen. Let’s learn more about this compound (cas:2343-22-8).

To endow metal-free materials with the high catalytic activity that is typically featured by a metal-based catalyst is yet a constant pursuit in the field of catalytic chem. In this work, novel functional biochars (DCNs) were prepared from wheat straw for the first time via a simple strategy of reconstructing the catalytic active sites in carbon precursors and subsequent controlled carbonization, which may be further applied in the oxidative dehydrogenation of N-heterocycles with ambient air as the oxidant. Whereas the superhydrophobicity of DCN-850 can effectively remove the only byproduct water to effectively reduce the possible effects of water on the catalyst, it also can decrease mass transfer resistance on active sites, thereby ensuring the reaction with high efficiencies and good generality. Especially, after several reuses, the activity and structures of DCN-850 remained unchanged in the catalytic system with water as a solvent. Furthermore, various characterization technologies and the model reaction were used to investigate the architectural attributes of DCNs, and the results show that there is a pos. correlation between the catalytic performance and hydrophobicity of DCNs, as well as reveal that the catalytic active sites may be made up of a five-membered-ring ketone or its enol form and possibly a phenolic unit, which could be encapsulated in internal structures of catalysts and promote the reaction via the recycling of -C-C-OH and -C-C=O groups by the pathway of catalytic hydrogen transfer.

Compound(2343-22-8)Quality Control of 5-Fluoroindoline received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(5-Fluoroindoline), if you are interested, you can check out my other related articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Formula: C8H8FN. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Oxidative Palladium(II)-Catalyzed C-7 Alkenylation of Indolines. Author is Jiao, Lin-Yu; Oestreich, Martin.

N-(dimethylcarbamoyl)indolines such as I underwent regioselective and stereoselective alkenylation with electron-deficient alkenes and styrenes RR1C:CHR2 [R = BuO2C, MeO2C, EtO2C, PhCH2O2C, MeCO, NC, (EtO)2P(:O), Ph, F5C6, 4-FC6H4, 4-ClC6H4, 2-ClC6H4, 2-BrC6H4; R1, R2 = H, Me] with 1,4-benzoquinone in acetic acid in the presence of Pd(OAc)2 and p-toluenesulfonic acid to give (E)-7-alkenylindolinecarboxamides such as II in 21-89% yield and all except II (R = MeO2C; R1 = H; R2 = Me) as the (E)-isomers in >98:2 dr. The tetrasubstituted urea moiety functioned as a directing group for directed alkenylation; non-urea directing groups either yielded alkenylation products in low (20%) yield or did not yield alkenylation products. An ethylcarbamoylindoline underwent alkenylation with Bu acrylate followed by cyclization to give oxoindolopyrimidineacetate III.

Compound(2343-22-8)Formula: C8H8FN received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(5-Fluoroindoline), if you are interested, you can check out my other related articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Rh(III)-Catalyzed direct C-7 amination of indolines with anthranils, the main research direction is pyrimidylindoline anthranil preparation rhodium catalyst amination; pyrimidylindolinyl aminobenzaldehyde preparation.Quality Control of 5-Fluoroindoline.

An efficient and practical method for the C-7 amination of indolines via Rh(III)-catalyzed C-H activation was reported. This reaction afforded various C-7 aminated indolines in good to excellent yields by using readily available anthranils as the aminating agents. The corresponding indolines with an amino and a carbonyl group together provided an opportunity for the construction and modification of diverse indoles and indolines in the pharmaceutical industry.

Here is just a brief introduction to this compound(2343-22-8)Quality Control of 5-Fluoroindoline, more information about the compound(5-Fluoroindoline) is in the article, you can click the link below.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Computed Properties of C8H8FN. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Design, synthesis and biological evaluation of novel 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole triazole derivatives as potent TRPV1 antagonists. Author is Li, Jinyu; Nie, Cunbin; Qiao, Yue; Hu, Jing; Li, Qifei; Wang, Qiang; Pu, Xiaohui; Yan, Lin; Qian, Hai.

The design, synthesis, and pharmacol. evaluation of a class of TRPV1 antagonists constructed on 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole as A-region and triazole as B-region I (R = 2-Cl 2,5-Me2, 2-NO2-4-Cl, etc.) have been reported. The SAR anal. indicated that 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole analogs I displayed excellent antagonism of hTRPV1 activation by capsaicin and showed better potency compared to the corresponding dihydroindole analogs. Optimization of this design led to the eventual identification of compound I (R = 2-CF3), a potent TRPV1 antagonist. In vitro, using cells expressing recombinant human TRPV1 channels, I (R = 2-CF3) displayed potent antagonism activated by capsaicin (IC 50 = 0.075 μM) and only partially blocked acid activation of TRPV1. In vivo, I (R = 2-CF3) exhibited good efficacy in capsaicin-induced and heat-induced pain models and had almost no hyperthermia side-effect. Furthermore, pharmacokinetic studies revealed that compound I (R = 2-CF3) had a superior oral exposure after oral administration in rats. To understand its binding interactions with the receptor, the docking study of I (R = 2-CF3) was performed in rTRPV1 model and showed an excellent fit to the binding site. On the basis of its superior profiles, I (R = 2-CF3) could be considered as the lead candidate for the further development of antinociceptive drugs.

Compound(2343-22-8)Computed Properties of C8H8FN received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(5-Fluoroindoline), if you are interested, you can check out my other related articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Formula: C8H8FN. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Oxidative Palladium(II)-Catalyzed C-7 Alkenylation of Indolines. Author is Jiao, Lin-Yu; Oestreich, Martin.

N-(dimethylcarbamoyl)indolines such as I underwent regioselective and stereoselective alkenylation with electron-deficient alkenes and styrenes RR1C:CHR2 [R = BuO2C, MeO2C, EtO2C, PhCH2O2C, MeCO, NC, (EtO)2P(:O), Ph, F5C6, 4-FC6H4, 4-ClC6H4, 2-ClC6H4, 2-BrC6H4; R1, R2 = H, Me] with 1,4-benzoquinone in acetic acid in the presence of Pd(OAc)2 and p-toluenesulfonic acid to give (E)-7-alkenylindolinecarboxamides such as II in 21-89% yield and all except II (R = MeO2C; R1 = H; R2 = Me) as the (E)-isomers in >98:2 dr. The tetrasubstituted urea moiety functioned as a directing group for directed alkenylation; non-urea directing groups either yielded alkenylation products in low (20%) yield or did not yield alkenylation products. An ethylcarbamoylindoline underwent alkenylation with Bu acrylate followed by cyclization to give oxoindolopyrimidineacetate III.

Compound(2343-22-8)Formula: C8H8FN received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(5-Fluoroindoline), if you are interested, you can check out my other related articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Formula: C8H8FN. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Palladium-Catalyzed Remote 1,n-Arylamination of Unactivated Terminal Alkenes. Author is Han, Chunhua; Fu, Zhiyuan; Guo, Songjin; Fang, Xinxin; Lin, Aijun; Yao, Hequan.

A palladium-catalyzed remote 1,n-arylamination (from 1,3- to 1,11-arylamination) of unactivated terminal alkenes with aryl iodides and arylamines has been realized. This three-component reaction proceeded via Pd-catalyzed Heck arylation, alkene isomerization, and aza-Michael addition, exhibiting good regio- and chemoselectivity, and wide substrate scope. Preliminary mechanistic studies indicated that the in situ generated ortho/para-quinone methide intermediates served as the driving force for the alkene isomerization and promoted the rearomatization upon nucleophilic amination.

Compound(2343-22-8)Formula: C8H8FN received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(5-Fluoroindoline), if you are interested, you can check out my other related articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Fluoroindoline( cas:2343-22-8 ) is researched.Quality Control of 5-Fluoroindoline.Pang, Shaofeng; Liu, Fangfang; Zhang, Yujing; Dong, Zhaowen; Su, Qiong; Wang, Wenfang; Li, Zhenhua; Zhou, Feng; Wang, Yanbin published the article 《Construction of Functional Superhydrophobic Biochars as Hydrogen Transfer Catalysts for Dehydrogenation of N-Heterocycles》 about this compound( cas:2343-22-8 ) in ACS Sustainable Chemistry & Engineering. Keywords: construction functional superhydrophobic biochars hydrogen transfer catalyst dehydrogenation nitrogen. Let’s learn more about this compound (cas:2343-22-8).

To endow metal-free materials with the high catalytic activity that is typically featured by a metal-based catalyst is yet a constant pursuit in the field of catalytic chem. In this work, novel functional biochars (DCNs) were prepared from wheat straw for the first time via a simple strategy of reconstructing the catalytic active sites in carbon precursors and subsequent controlled carbonization, which may be further applied in the oxidative dehydrogenation of N-heterocycles with ambient air as the oxidant. Whereas the superhydrophobicity of DCN-850 can effectively remove the only byproduct water to effectively reduce the possible effects of water on the catalyst, it also can decrease mass transfer resistance on active sites, thereby ensuring the reaction with high efficiencies and good generality. Especially, after several reuses, the activity and structures of DCN-850 remained unchanged in the catalytic system with water as a solvent. Furthermore, various characterization technologies and the model reaction were used to investigate the architectural attributes of DCNs, and the results show that there is a pos. correlation between the catalytic performance and hydrophobicity of DCNs, as well as reveal that the catalytic active sites may be made up of a five-membered-ring ketone or its enol form and possibly a phenolic unit, which could be encapsulated in internal structures of catalysts and promote the reaction via the recycling of -C-C-OH and -C-C=O groups by the pathway of catalytic hydrogen transfer.

Compound(2343-22-8)Quality Control of 5-Fluoroindoline received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(5-Fluoroindoline), if you are interested, you can check out my other related articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Hydrogenation or Dehydrogenation of N-Containing Heterocycles Catalyzed by a Single Manganese Complex, the main research direction is manganese complex preparation; heterocycle manganese complex catalyst chemoselective hydrogenation.HPLC of Formula: 2343-22-8.

A highly chemoselective base-metal catalyzed hydrogenation and acceptorless dehydrogenation of N-heterocycles was presented. A well-defined Mn-complex was operated at low catalyst loading (as low as 2 mol%) and under mild reaction conditions. The described catalytic system tolerated various functional groups and the corresponding reduced heterocycles was obtained in high yields. Exptl. studies indicated a metal ligand cooperative catalysis mechanism.

In some applications, this compound(2343-22-8)HPLC of Formula: 2343-22-8 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics