Category: 2343-22-8

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called A General and Highly Selective Cobalt-Catalyzed Hydrogenation of N-Heteroarenes under Mild Reaction Conditions, published in 2017, which mentions a compound: 2343-22-8, Name is 5-Fluoroindoline, Molecular C8H8FN, Recommanded Product: 2343-22-8.

Herein, a general and efficient method for the homogeneous cobalt-catalyzed hydrogenation of N-heterocycles, under mild reaction conditions, is reported. Key to success is the use of the tetradentate ligand tris(2-(diphenylphosphino)phenyl)phosphine. This non-noble metal catalyst system allows the selective hydrogenation of heteroarenes in the presence of a broad range of other sensitive reducible groups.

After consulting a lot of data, we found that this compound(2343-22-8)Recommanded Product: 2343-22-8 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Medicinal Chemistry called New Generation of Selective Androgen Receptor Degraders: Our Initial Design, Synthesis, and Biological Evaluation of New Compounds with Enzalutamide-Resistant Prostate Cancer Activity, Author is Hwang, Dong-Jin; He, Yali; Ponnusamy, Suriyan; Mohler, Michael L.; Thiyagarajan, Thirumagal; McEwan, Iain J.; Narayanan, Ramesh; Miller, Duane D., which mentions a compound: 2343-22-8, SMILESS is FC1=CC2=C(NCC2)C=C1, Molecular C8H8FN, Reference of 5-Fluoroindoline.

In our effort to find small-mol. treatments of advanced prostate cancers (PCs), a novel series of indolyl and indolinyl propanamides (series II and III) were discovered as selective androgen receptor degraders (SARDs). Initial studies of androgen receptor (AR) antagonist (1) and agonist (2) propanamides yielded a tertiary aniline (3) with novel SARD activity but poor metabolic stability. Cyclization to II and III produced submicromolar AR antagonism and protein degradation selective to AR and AR splice variant (AR SV). II and III maintained potency against enzalutamide-resistant (Enz-R) mutant ARs and PC cells and were efficacious in Enz-R xenografts, suggesting their potential to treat advanced PCs. Design, synthesis, and biol. activity of novel SARDs that could potentially be used for the treatment of a wide spectrum of PCs including castration-resistant, Enz-R, and/or AR SV-dependent advanced PCs that are often untreatable with known hormone therapies are discussed.

After consulting a lot of data, we found that this compound(2343-22-8)Reference of 5-Fluoroindoline can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Medicinal Chemistry called New Generation of Selective Androgen Receptor Degraders: Our Initial Design, Synthesis, and Biological Evaluation of New Compounds with Enzalutamide-Resistant Prostate Cancer Activity, Author is Hwang, Dong-Jin; He, Yali; Ponnusamy, Suriyan; Mohler, Michael L.; Thiyagarajan, Thirumagal; McEwan, Iain J.; Narayanan, Ramesh; Miller, Duane D., which mentions a compound: 2343-22-8, SMILESS is FC1=CC2=C(NCC2)C=C1, Molecular C8H8FN, Reference of 5-Fluoroindoline.

In our effort to find small-mol. treatments of advanced prostate cancers (PCs), a novel series of indolyl and indolinyl propanamides (series II and III) were discovered as selective androgen receptor degraders (SARDs). Initial studies of androgen receptor (AR) antagonist (1) and agonist (2) propanamides yielded a tertiary aniline (3) with novel SARD activity but poor metabolic stability. Cyclization to II and III produced submicromolar AR antagonism and protein degradation selective to AR and AR splice variant (AR SV). II and III maintained potency against enzalutamide-resistant (Enz-R) mutant ARs and PC cells and were efficacious in Enz-R xenografts, suggesting their potential to treat advanced PCs. Design, synthesis, and biol. activity of novel SARDs that could potentially be used for the treatment of a wide spectrum of PCs including castration-resistant, Enz-R, and/or AR SV-dependent advanced PCs that are often untreatable with known hormone therapies are discussed.

After consulting a lot of data, we found that this compound(2343-22-8)Reference of 5-Fluoroindoline can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called A General and Highly Selective Cobalt-Catalyzed Hydrogenation of N-Heteroarenes under Mild Reaction Conditions, published in 2017, which mentions a compound: 2343-22-8, Name is 5-Fluoroindoline, Molecular C8H8FN, Recommanded Product: 2343-22-8.

Herein, a general and efficient method for the homogeneous cobalt-catalyzed hydrogenation of N-heterocycles, under mild reaction conditions, is reported. Key to success is the use of the tetradentate ligand tris(2-(diphenylphosphino)phenyl)phosphine. This non-noble metal catalyst system allows the selective hydrogenation of heteroarenes in the presence of a broad range of other sensitive reducible groups.

After consulting a lot of data, we found that this compound(2343-22-8)Recommanded Product: 2343-22-8 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Related Products of 2343-22-8. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Discovery and Optimization of Pyrimidone Indoline Amide PI3Kβ Inhibitors for the Treatment of Phosphatase and Tensin Homologue (PTEN)-Deficient Cancers.

Compelling mol. biol. publications have reported the implication of phosphoinositide kinase PI3Kβ in PTEN-deficient cell line growth and proliferation. These findings supported a scientific rationale for the development of PI3Kβ-specific inhibitors for the treatment of PTEN-deficient cancers. This paper describes the discovery of 2-[2-(2,3-dihydro-indol-1-yl)-2-oxo-ethyl]-6-morpholin-4-yl-3H-pyrimidin-4-one and the optimization of this new series of active and selective pyrimidone indoline amide PI3Kβ inhibitors. 2-[2-(2-Methyl-2,3-dihydro-indol-1-yl)-2-oxo-ethyl]-6-morpholin-4-yl-3H-pyrimidin-4-one (I), identified following a carefully designed Me scan, displayed improved physicochem. and in vitro pharmacokinetic properties. Structural biol. efforts enabled the acquisition of the first x-ray cocrystal structure of p110β with the selective inhibitor compound I bound to the ATP site. The nonplanar binding mode described herein is consistent with observed structure-activity relationship for the series. Compound I demonstrated significant in vivo activity in a UACC-62 xenograft model in mice, warranting further preclin. investigation. Following successful development, compound 28 entered phase I/Ib clin. trial in patients with advanced cancer.

Although many compounds look similar to this compound(2343-22-8)Related Products of 2343-22-8, numerous studies have shown that this compound(SMILES:FC1=CC2=C(NCC2)C=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Wang, Xuan; Tang, Huanyu; Feng, Huijin; Li, Yuanchao; Yang, Yaxi; Zhou, Bing researched the compound: 5-Fluoroindoline( cas:2343-22-8 ).Recommanded Product: 5-Fluoroindoline.They published the article 《Access to Six- and Seven-Membered 1,7-Fused Indolines via Rh(III)-Catalyzed Redox-Neutral C7-Selective C-H Functionalization of Indolines with Alkynes and Alkenes》 about this compound( cas:2343-22-8 ) in Journal of Organic Chemistry. Keywords: diazepinoindoline preparation; pyridoindoline preparation; pyrroloquinolinone preparation; indoline derivative annulation alkene alkyne; acrylate aza Michael addition indoline derivative; alkenylation indoline derivative acrylate. We’ll tell you more about this compound (cas:2343-22-8).

We report herein a new strategy for the Rh(III)-catalyzed redox-neutral C7-selective C-H activation/annulation of indolines to rapidly access various privileged 1,7-fused indolines by utilizing an oxidizing-directing group. For example, a Rh(III)-catalyzed redox-neutral C7-selective C-H functionalization of indolines, e.g., I [R = OMe, O2CCMe3, R1 = H; R = OMe, R1 = Me-2, Me-3, (CH2)5-3,3, Me-4, Me-5, OMe-5, Cl-5, Br-5, CO2Me-5] with arylalkynes, e.g., II [R2 = H, Me-4, OMe-4, F-4, Me-3], is described to directly access 7-membered 1,7-fused indolines, e.g., III [R1 = Me-2, Me-3, (CH2)5-3,3, Me-4, Me-5, OMe-5, Cl-5, Br-5, CO2Me-5, R2 = H; R1 = H, R2 = H, Me-4, OMe-4, F-4, Me-3]. Moreover, an unprecedented intramol. addition of an alkenyl-Cp*Rh(III) species to a carbamoyl moiety occurred to give 1H-pyrroloquinolinones, e.g., IV [R1 = Me-2, Me-3, (CH2)5-3,3, Me-4, Me-5, OMe-5, Cl-5, Br-5, CO2Me-5, R3 = Et; R1 = H, R3 = Me, Pr, Bu], when employing alkyl alkynes, e.g., R3CCR3. Addnl., an efficient Rh(III)-catalyzed redox-neutral C7-selective C-H activation/alkenylation/aza-Michael addition of indolines is also developed to give 6-membered 1,7-fused indolines, e.g., V [R1 = H, Me-4, Me-5, OMe-5, Cl-5, Br-5, F-5, OMe-6, R4 = CO2Me; R1 = H, R4 = CO2Et, CO2Bu, CO2CMe3, CO2CH2Ph, SO2Ph, CN, P(:O)(OEt)2] . The advantages of these processes are as follows: (1) mild and simple reaction conditions; (2) no need for an external oxidant; (3) broad scope of substrates; and (4) valuable six- or seven-membered 1,7-fused indolines as products.

Although many compounds look similar to this compound(2343-22-8)Recommanded Product: 5-Fluoroindoline, numerous studies have shown that this compound(SMILES:FC1=CC2=C(NCC2)C=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Fluoroindoline( cas:2343-22-8 ) is researched.Electric Literature of C8H8FN.Shi, Yunkai; Chen, Chao; Yang, Yaxi; Bing, zhou published the article 《Rh(III)-catalyzed selective C7-H functionalization of indolines with 1,3-enynes enables access to six-membered 1,7-fused indolines》 about this compound( cas:2343-22-8 ) in Tetrahedron Letters. Keywords: fused indoline preparation diastereoselective; indoline enyne cyclization rhodium catalyst. Let’s learn more about this compound (cas:2343-22-8).

Herein a Rh(III)-catalyzed C7-selective C-H activation/annulation of indolines I (R = H, OMe, F; R1 = H, Me, Br, Cl, F, OMe; R2 = H, Me; R3 = H, Me; R4 = H; R3R4 = -(CH2)5-; R5 = H, Me; R4R5 = -CH=CH-CH=CH-) with 1,3-enynes R6CCCH=C(CH3)2 (R6 = n-Bu, cyclopropyl, Ph, etc.) to efficiently access various privileged 1,7-fused indolines II bearing an all-carbon quaternary stereogenic carbon center was described. Notably, the resulting products II (R = R1 = R2 = R3 = R4 = R5 = H; R6 = cyclopropyl) can be readily transformed into 1,7-fused indoles III, further widening the C-7 derivatization of indoles and highlighting the synthetic utility of this methodol.

Although many compounds look similar to this compound(2343-22-8)Electric Literature of C8H8FN, numerous studies have shown that this compound(SMILES:FC1=CC2=C(NCC2)C=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Formula: C8H8FN. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Rh(III)-Catalyzed C7-Thiolation and Selenation of Indolines. Author is Xie, Wucheng; Li, Bin; Wang, Baiquan.

The rhodium(III)-catalyzed intermol. C7-thiolation and selenation of indolines with disulfides and diselenides were developed. This protocol relies on the use of a removable pyrimidyl directing group to access valuable C-7 functionalized indoline scaffolds with ample substrate scope and broad functional group tolerance.

Although many compounds look similar to this compound(2343-22-8)Formula: C8H8FN, numerous studies have shown that this compound(SMILES:FC1=CC2=C(NCC2)C=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-Fluoroindoline(SMILESS: FC1=CC2=C(NCC2)C=C1,cas:2343-22-8) is researched.Product Details of 53636-17-2. The article 《Arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Optimization of P1 and N-aryl》 in relation to this compound, is published in Bioorganic & Medicinal Chemistry Letters. Let’s take a look at the latest research on this compound (cas:2343-22-8).

A systematic study of anilines led to the discovery of a metabolically robust fluoroindoline replacement for the alkoxy aniline toxicophore in 1. Investigations of the P1 pocket resulted in the discovery of a wide tolerance of functionality leading to the discovery of 11 as a potent and selective inhibitor of cathepsin S.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Name: 5-Fluoroindoline. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Ruthenium-catalyzed C7 amidation of indoline C-H bonds with sulfonyl azides. Author is Pan, Changduo; Abdukader, Ablimit; Han, Jie; Cheng, Yixiang; Zhu, Chengjian.

A ruthenium-catalyzed direct C7 amidation of indoline C-H bonds with sulfonyl azides was developed. This procedure allows the synthesis of a variety of 7-amino-substituted indolines, which are useful in pharmaceutical. The good functional tolerances, as well as the mild conditions, are prominent feature of this method.

In some applications, this compound(2343-22-8)Name: 5-Fluoroindoline is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics