Category: 21867-64-1

The preparation and reaction of enolates within micro reactors was written by Wiles, Charlotte;Watts, Paul;Haswell, Stephen J.;Pombo-Villar, Esteban. And the article was included in Tetrahedron in 2005.Computed Properties of C7H16N2 This article mentions the following:

Over the past 5 years, interest in the miniaturization of chem. synthesis has grown rapidly, however in order to facilitate transfer of the technol. from its current position as a research tool to industrial applications, a core understanding of the challenges associated with transferring reactions from the macro to the micro domain is required. This paper therefore aims to broach this problem by investigating the application of micro reactors to a range of commonly employed synthetic reactions including acylation, aldol, alkylation, 1,4-conjugate addition (Michael addition) and the Knoevenagel condensation. Comparison of the results obtained with traditional batch techniques aimed to highlight some of the advantages associated with micro reaction technol. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Computed Properties of C7H16N2).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Computed Properties of C7H16N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Two birds with one stone: dendrimer surface engineering enables tunable periphery hydrophobicity and rapid endosomal escape was written by Wang, Zheng;Chen, Chao;Liu, Ruihong;Fan, Aiping;Kong, Deling;Zhao, Yanjun. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2014.Quality Control of 1-Propylpiperazine This article mentions the following:

Multifunctional thermosensitive dendrimeric nanocarriers were generated via tailored surface modification. Such design not only facilitated the rapid endosomal escape of dendrimers, but also achieved tunable surface hydrophobicity, which could be employed to achieve on-demand cargo release. These smart dendrimers are promising for enhancing intracellular drug delivery. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Quality Control of 1-Propylpiperazine).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Quality Control of 1-Propylpiperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Novel water-soluble sedative-hypnotic agents: isoindolin-1-one derivatives was written by Kanamitsu, Norimasa;Osaki, Takashi;Itsuji, Yutaka;Yoshimura, Masakazu;Tsujimoto, Hisashi;Soga, Manabu. And the article was included in Chemical & Pharmaceutical Bulletin in 2007.Synthetic Route of C7H16N2 This article mentions the following:

The authors developed new i.v. sedative-hypnotic compounds with the isoindolin-1-one skeleton focusing on the water-soluble property and in vivo safety. The authors synthesized approx. 170 derivatives and evaluated their hypnotic effects by i.v. administration of the compounds to mice. A series of the 2-phenyl-3-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]isoindolin-1-one analogs (I–IV) showed potent sedative-hypnotic activity with good water solubility and a wide safety margin. The hypnotic doses (HD₅₀s) of these 4 compounds when administered to mice were 2.35, 1.90, 2.17, and 3.12 mg/kg, resp., and the LDs (LD₅₀s) were 88.67, 64.69, >120, and >120 mg/kg, resp. The therapeutic indexes (LD₅₀/HD₅₀) were 37.73, 34.05, >55.30, and >38.46, resp. Among these IV is being considered as the most potential candidate for clin. trials in humans. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Synthetic Route of C7H16N2).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 鎺矯 and boils at 125閳?30 鎺矯. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Synthetic Route of C7H16N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Chemotherapeutically active nitro compounds. 4. 5-Nitroimidazoles. Part II was written by Winkelmann, E.;Raether, W.;Sinharay, A.. And the article was included in Arzneimittel-Forschung in 1978.Application In Synthesis of 1-Propylpiperazine This article mentions the following:

About 190 nitroimidazoles I [R = morpholino, 4-methylpiperazino, N₃, p-ClC₆H₄COCH₂S, PhS, MeOCS₂, H₂NC(:NH)S, MeNH, etc.; R¹ = Me, Et] were prepared Thus, I (R = Cl, R¹ = Me) was treated with 2-mercaptopyridine to give 80% I (R = 2-pyridylthio, R¹ = Me). 1-Methyl-2-(S-isothiouroniummethyl)-5-nitroimidazole-HCl and 2-bromo-5-nitrofuran gave 65% I (R = 5-nitro-2-furylthio, R¹ = Me). The chemotherapeutic effect against several protozoa species was tabulated. Some I were also bactericidal, nematocidal, and fungicidal. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Application In Synthesis of 1-Propylpiperazine).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Application In Synthesis of 1-Propylpiperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Amino-substituted heterocycles as isosteres of trans-cinnamides: design and synthesis of heterocyclic biaryl sulfides as potent antagonists of LFA-1/ICAM-1 binding was written by Wang, Gary T.;Wang, Sheldon;Gentles, Robert;Sowin, Thomas;Leitza, Sandra;Reilly, Edward B.;von Geldern, Thomas W.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Synthetic Route of C7H16N2 This article mentions the following:

2-Amino-4-Ph pyridine and to a lesser extent, 4-amino-6-Ph pyrimidine were established as isosteres of trans-cinnamide moiety. Applying this isosterism to previously reported p-arylthio cinnamides resulted in the identification of 4-amino-6-(p-arylthio)phenylpyrimidines and 2-amino-4-(p-arylthio)phenylpyridines I (X = N, CH, R¹ = 2-Me₂CH; X = CH, R¹ = 2-MeO, 3,4-OCH₂CH₂O; R²R³N = pyrrolidinyl, 4-hydroxypiperidinyl, 4-formyl-1-piperazinyl, etc.) as potent antagonists of LFA-1/ICAM-1 binding. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Synthetic Route of C7H16N2).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Synthetic Route of C7H16N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Silica-immobilized piperazine: A sustainable organocatalyst for aldol and Knoevenagel reactions was written by Shanmuganathan, Saravanakumar;Greiner, Lasse;Dominguez de Maria, Pablo. And the article was included in Tetrahedron Letters in 2010.Recommanded Product: 1-Propylpiperazine This article mentions the following:

Silica-supported piperazine was found to be an efficient catalyst for aldol reactions of aromatic aldehydes and ketones with straightforward product isolation and catalyst reuse. Furthermore, the catalyst is active in Knoevenagel-type reactions to afford coumarin derivatives, using 2-methyltetrahydrofuran (2-MeTHF) as a novel bio-based solvent. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Recommanded Product: 1-Propylpiperazine).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Recommanded Product: 1-Propylpiperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

New compounds and reactions of sulfonamides with amines. XXXI. Syntheses of some N-[4-[2-(acylamino)ethyl]benzenesulfonyl]-4-alkylpiperazine-1-carboxamides was written by Gajewski, Feliks;Kozakiewicz, Irena. And the article was included in Acta Poloniae Pharmaceutica in 1982.Product Details of 21867-64-1 This article mentions the following:

Nineteen title compounds I (R = Me, R¹ = 2-ClC₆H₄, 3-ClC₆H₄, 2-BrC₆H₄, 2-MeC₆H₄, 4-NO₂C₆H₄, 2,4-Cl₂C₆H₃, 2,5-(MeO)ClC₆H₃, 2-furyl, pyridyl, 2-quinolyl, 2-pyrazinyl, 2-amino-3-pyrazinyl; R = Et, Pr, R¹ = 2,5-(MeO)ClC₆H₃, 2-pyrazinyl; R = Bu, R¹ = 2-pyrazinyl) were prepared as potential hypoglycemic agents. Most I were prepared by heating 4-[R¹CONH(CH₂)₂]C₆H₄SO₂NHCONH₂ with a substituted piperazine in dioxane. I [R = Me, R¹ = 2,5-(MeO)ClC₆H₃] was prepared from 4-[R¹CONH(CH₂)₂]C₆H₄SO₂NHCONHCO₂Me and N-methylpiperazine in PhMe. I (R = Me, R¹ = 2-pyrazinyl) was also obtained via I (R = Me, R¹ = Me) which was deacetylated with aqueous NaOH and the product acylated with pyrazine-2-carboxylic acid chloride in C₆H₁₂. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Product Details of 21867-64-1).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Product Details of 21867-64-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Influence of external stimuli on the network properties of cationic poly(N-acryloyl-N’-propyl piperazine) hydrogels was written by Deen, G. Roshan;Mah, Chin Hao. And the article was included in Polymer in 2016.Related Products of 21867-64-1 This article mentions the following:

Stimuli-responsive cationic hydrogels based on N-acryloyl-N’-Pr piperazine (AcrNPP) crosslinked with N,N’-methylenebisacrylamide (Mba) and 1,4-butanedioldiacrylate (Bda) were prepared by UV light-initiated free-radical polymerization in bulk. The effect of external stimuli and type of crosslinker on the equilibrium swelling behavior and dynamic swelling was investigated in detail in buffer solution of various pH and temperatures The equilibrium swelling capacity of the gels was large in swelling medium at pH 3.0 than at pH 10.0 due to ionization of polymer network under acidic conditions. With increase in temperature from 25 鎺矯 to 45 鎺矯, the gels exhibited neg. temperature-responsive (thermo-shrinking/thermophobic) behavior with neg. activation energy for diffusion of water. The thermodn. parameters such as Gibbs’ free energy (铻朑), enthalpy (铻朒), and entropy (铻朣) for the swelling of gels as function of temperature were neg. indicating an exothermic swelling process. Water (media) transport mechanism and diffusion process in thin rectangular gels was studied. At pH 3.0, the diffusion process was non-Fickian (anomalous) while at pH 10.0 it was quasi-Fickian. The transport mechanism was partly influenced by the type of crosslinker in the gel. The dynamic swelling data was analyzed using early-time, late-time and Etters diffusion models. From the equilibrium swelling studies the average mol. weight between crosslinks (M_c), the crosslink d. (锜?sub>c), and the mesh size (灏? were determined The M_c was large at pH 3.0 due to ionization of polymer and chain expansion. The exptl. M_c was much larger than the theor. M_c which implied that the gels were loosely crosslinked real networks. The mesh size of gels were between 447 and 786 鑴?in the swollen (ionized) state (pH 3.0), and between 100 and 231 鑴?in the collapsed (non-ionized) state (pH 10.0). The mesh size increased between three to four times during the pH-dependent swelling transition. The state of water in fully swollen hydrogels which influences many important biomaterial properties was determined by differential scanning calorimetry. The bound water content of gels increased linearly with increase in pH of the swelling medium while the unbound water decreased. These hydrogels have potential to be used as controlled drug delivery systems and sorbents for removal of pollutants from water. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Related Products of 21867-64-1).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Related Products of 21867-64-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Molecular Simplification of 1,4-Diazabicyclo[4.3.0]nonan-9-ones Gives Piperazine Derivatives That Maintain High Nootropic Activity was written by Manetti, Dina;Ghelardini, Carla;Bartolini, Alessandro;Dei, Silvia;Galeotti, Nicoletta;Gualtieri, Fulvio;Romanelli, Maria Novella;Teodori, Elisabetta. And the article was included in Journal of Medicinal Chemistry in 2000.SDS of cas: 21867-64-1 This article mentions the following:

Several 4-substituted 1-acylpiperazines, obtained by mol. simplification of 4-substituted 1,4-diazabicyclo[4.3.0]nonan-9-ones, have been synthesized and tested in vivo on the mouse passive avoidance test, to evaluate their nootropic activity. The results show that, apparently, an N-acylpiperazine group can mimic the 2-pyrrolidinone ring of 1,4-diazabicyclo[4.3.0]nonan-9-one, as the compounds of the new series maintain high nootropic activity. Moreover mol. simplification produces more clear-cut structure-activity relationships with respect to the parent series. The mechanism of action also appears to be similar in the two series. In fact, although the mol. mechanism remains to be elucidated, the most potent compound of each class is able to increase acetylcholine release in rat brain. Piperazine derivatives represent a new class of nootropic drugs with an in vivo pharmacol. profile very similar to that of piracetam, showing much higher potency with respect to the reference compound Among the compounds studied, 1-benzoyl-4-propionylpiperazine (DM235) shows outstanding potency, being active at a dose of 0.001 mg kg^-1 s.c. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1SDS of cas: 21867-64-1).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.SDS of cas: 21867-64-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Novel 4-substituted 2-piperazinylquinazolines as potent anticonvulsive and antihypoxic agents was written by Hori, Manabu;Iemura, Ryuichi;Hara, Hideaki;Ozaki, Akio;Sukamoto, Takayuki;Ohtaka, Hiroshi. And the article was included in Chemical & Pharmaceutical Bulletin in 1990.Synthetic Route of C7H16N2 This article mentions the following:

Piperazinylquinazolines, e.g. I [R = Me, Ph, CH₂Ph, CH₂CH:CH₂, (CH₂)_nMe, R¹ = Me, CH₂Ph, (CH₂)_nMe, n = 2-4] were prepared and examined for anticonvulsive and antihypoxic activities. The anal. of quant. structure-activity relationships indicated that the anticonvulsive activity was related to the lipophilicity of the compounds Most of the alkoxyquinazolines I showed potent anticonvulsive and antihypoxic activities. There is a good correlation between the potencies of these activities. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Synthetic Route of C7H16N2).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Synthetic Route of C7H16N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics