Category: 21655-48-1

21655-48-1, cis-2,6-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

PREPARATION 76 1-(1,1-Dimethylethoxycarbonyl)-cis-3,5-dimethylpiperazine Di-tert-butyldicarbonate (5.42 g) in dry methylene chloride (20 ml) is added to a solution of cis-2,6-dimethylpiperazine in dry methylene chloride (70 ml) over one hour. The mixture is stirred an additional 30 rain, washed with water and saline, dried over sodium sulfate and concentrated to give the title compound, NMR (chloroform-d) 3.95, 2.77, 2.32, 1.46, 1.06 delta., 21655-48-1

As the paragraph descriping shows that 21655-48-1 is playing an increasingly important role.

Reference£º
Patent; The Upjohn Company; US5599930; (1997); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21655-48-1, cis-2,6-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

INTERMEDIATE 81fert-ButvK^-l-(2-rr35l.5i?V3.5-dimethvbiperazin-l-yll-7-fluoro-8-methylquinolin-3- yl } ethylcarbamateTo a solution of Intermediate 27 (500 mg, 1.48 mmol) in NMP (6 mL) were added (25′,6i?)-2,6-drmethylpiperazine (340 mg, 3.00 mmol) and DIPEA (1.3 mL) and the resulting solution was heated at 14O0C for 16 h. The reaction mixture was taken up in EtOAc (150 mL) and washed with water (2 x 50 mL) and brine (50 mL). The organic phase was separated, dried (MgSO4), filtered and the solvent removed in vacuo. Purification by column chromatography (SiO2, 0-5percent MeOH in EtOAc) gave the title compound (530 mg, 86percent) as a beige solid. deltaH (CDCl3) 7.90 (IH, s), 7.49 (IH, dd, J 8.87, 6.12 Hz), 7.12 (IH, t, .78.98 Hz)5 5.04 (2H, d, J38.75 Hz), 3.65 (IH, d, J 12.33 Hz), 3.43 (IH, d, J 12.40 Hz), 3.26 (IH, s), 3.14-3.09 (IH, m), 2.79 (IH5 1, J 11.35 Hz)5 2.60 (3H, d, J2.40 Hz)5 2.43 (IH51, J 11.28 Hz)5 1.48-1.42 (13H5 m), 1.15 (6H, dd5 J 14.95, 6.35 Hz).

21655-48-1, As the paragraph descriping shows that 21655-48-1 is playing an increasingly important role.

Reference£º
Patent; UCB PHARMA S.A.; ALLEN, Daniel, Rees; BUeRLI, Roland; HAUGHAN, Alan, Findlay; MACDONALD, Jonathan, David; MATTEUCCI, Mizio; NASH, David, John; OWENS, Andrew, Pate; RAPHY, Gilles; SAVILLE-STONES, Elizabeth, Anne; SHARPE, Andrew; WO2010/100405; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21655-48-1, cis-2,6-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

21655-48-1, A mixture of 2,5-dibromo-4-methylpyridine (3.5 g, 18.42 mmol), Hunig’s Base (9.63 mL,55.26 mmol) and (2R,6S)-2,6-dimethylpiperazine (2.314 g, 20.26 mmol) in DMSO (55 mL) was stirred at 110 ¡ãC for 18 hours. The reaction mixture was diluted with EtOAc (75 mL), and washed sequentially with water (2 x 50 mL) and saturated brine (25 mL). The organic layer was dried over MgSO4, filtered and concentrated to afford the crude (3S,5R)-1-(5-bromo-4-methylpyridin-2-yl)-3,5-dimethylpiperazine as an oil which crystallised on suanding to give a pale yellow solid (5.05 g, 96percent). Used with no further purification.

The synthetic route of 21655-48-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Holmes, Jane L.; Almeida, Lynsie; Barlaam, Bernard; Croft, Rosemary A.; Dishington, Allan P.; Gingipalli, Laksmaiah; Hassall, Lorraine A.; Hawkins, Janet L.; Ioannidis, Stephanos; Johannes, Jeffrey W.; McGuire, Thomas M.; Moore, Jane E.; Patel, Anil; Pike, Kurt G.; Pontz, Timothy; Wu, Xiaoyun; Wang, Tao; Zhang, Hai-Jun; Zheng, Xiaolan; Synthesis; vol. 48; 8; (2016); p. 1226 – 1234;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21655-48-1, cis-2,6-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

21655-48-1, EXAMPLE 24 Cis-3,5-dimethyl-1-(4-nitro-phenyl)-piperazine A suspension of 6.74 g (47.8 mmol) of 4-fluoro-nitro-benzene and 10.91 g (95.5 mmol) of cis-2,6-dimethyl-piperazine is heated at 45¡ã C. for 1 hour. The reaction mixture is cooled and shaken with dichloromethane and water. The organic layer is dried (magnesium sulfate) and concentrated to give 11.62 g (>100percent) of the product as a solid.

21655-48-1 cis-2,6-Dimethylpiperazine 6950261, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Booth, Richard John; Dobrusin, Ellen Myra; Josyula, Vara Prasad Venkata Nagendra; McNamara, Dennis Joseph; Toogood, Peter Laurence; US2003/73668; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21655-48-1, cis-2,6-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1. Preparation of 3,5-dimethyl-1-tert-butoxycarbonyl-piperazine (ZTH-1): [0025] Adding 2,6-lupetazin (11.4 g, 100 mmol, 1 eq) and di-tert-butyl dicarbonate (21.8 g, 100 mmol, leg) into a 250 ml flask; and then adding 100 ml tetrahydrofuran, reacting under room temperature for 4 hours; and condensing up tetrahydrofuran (i.e., condensing tetrahydrofuran until used up), 21.4 g orange-colored oily substance ZTH-1 is obtained, wherein the yield is 100%.

21655-48-1, The synthetic route of 21655-48-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Zhang, Nan; Zhong, Rong; US2013/116265; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21655-48-1, cis-2,6-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of methyl 4-(((3-chloro-N-phenylpropyl)sulfonamido)methyl)benzoate (0.500 g, 1.309 mmol), (2R,6S)-2,6-dimethylpiperazine (0.299 g, 2.6 19 mmol) and potassium carbonate (0.27 1 g, 1.964 mmol) in N,N-dimethylformide (3 mL) was stuffed at 80 ¡ãC for 18 hr and cooled down to the room temperature to terminate the reaction. Then, water was added to the reaction mixture, followed by extraction with ethyl acetate. The organic layer was washed with aqueous saturated sodium chloride solution, dried with anhydrous MgSO4, filtered, and concentrated in vacuo. The residue was chromatographed (Si02, 4 g cartridge; methanol / dichloromethane = 0 percent to 10 percent) to give methyl4-(((3-((3R,5S)-3 ,5-dimethylpiperazin- 1 -yl)-N-phenylpropyl) sulfonamido)methyl)benz oate as white solid (0.5 15 g, 85.6 percent)., 21655-48-1

21655-48-1 cis-2,6-Dimethylpiperazine 6950261, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; LEE, Jaekwang; HAN, Younghue; KIM, Yuntae; CHOI, Daekyu; MIN, Jaeki; BAE, Miseon; YANG, Hyunmo; KIM, Dohoon; (644 pag.)WO2017/18803; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21655-48-1, cis-2,6-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred suspension of 1?fluoro?4?nitrobenzene (562 mg, 3.98 mmol) and potassium carbonate (688 mg, 4.98 mmol) in anhydrous DMSO (2 mL) was added (2S,6R)?2,6? dimethylpiperazine (500 mg, 4.38 mmol) and the mixture heated at 100 ¡ãC for 16 h. After cooling the mixture wassuspended in water (40 mL) and filtered under vacuum to afford the title compound (889 mg, 95percent) . ?H NMR (500 MHz, DMSO?d6) : 3 8.03 (d, 2H) , 7.03 (d, 2H) , 3.88 (dd, 2H) 2.75?2.79 (m, 2H), 2.37?2.42 (m, 2H), 2.28 (br s, 1H),1.03 (d, 6H) . LCMS (Method C) : = 0.51 mi m/z = 236[M+H]., 21655-48-1

As the paragraph descriping shows that 21655-48-1 is playing an increasingly important role.

Reference£º
Patent; ALMAC DISCOVERY LIMITED; HARRISON, Timothy; TREVITT, Graham; HEWITT, Peter Robin; O’DOWD, Colin Roderick; BURKAMP, Frank; WILKINSON, Andrew John; SHEPHERD, Steven D.; MIEL, Hugues; WO2015/92431; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21655-48-1,cis-2,6-Dimethylpiperazine,as a common compound, the synthetic route is as follows.

Step 1: 3,5-Dimethyl-l-(4-trifluoromethoxy-bepizyl)-piperazine: To a solution of 4-(trifluoromethoxy)- benzaldehyde (776 muL, 4.38 mmol) in dichloromethane (30 mL) was added 2,6-dimethy. piperazine (1.0 g, 8.77mmol). The reaction mixture was stirred for Ih. Sodium triacetoxy borohydride (2.45 g, 8.77 mmol) was added and the reaction mixture was stirred for 4h. The reaction mixture was concentrated in vacuo, diluted with ethyl acetate and extracted with IN HCl (2 x 50 mL). The combined aqueous solution was neutralized with NaOH and extracted with ethyl acetate (3 x 50 mL). The combined organic solution was dried (Ts^SO,)) and concentrated in vacuo to provide 3,5-dimethyl-l-(4- trifluoromethoxy-benzyl)-piperazine (1.01 g, 80percent) as a clear oil. 1H NMR (400 MHz, CD3OD) delta 7.42 (d, 2H), 7.23 (d, 2H), 3.54 (s, 2H), 2.98-2.88 (m, 2H), 2.82-2.74,(m, 2H), 1.69 (t, 2H), 1.05 (d,6H); LCMS 289.5 (M+l)+.

21655-48-1, 21655-48-1 cis-2,6-Dimethylpiperazine 6950261, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; KALYPSYS, INC.; WO2007/47431; (2007); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21655-48-1,cis-2,6-Dimethylpiperazine,as a common compound, the synthetic route is as follows.

6-Bromo-3,4-dihydroisoquinolin-2(1H)-carboxylic acid tert-butyl ester (300 mg, 0.96 mmol), (2S,6R)-2,6-dimethylpiperazine at room temperature (131 mg, 1.15 mmol), BINAP (119 mg, 0.19 mmol),Sodium tert-butoxide (276 mg, 2.88 mmol), Pd2 (dba) 3 (87.9 mg, 0.10 mmol) and toluene (6 mL) were added to the reaction flask. Sealed, replaced with nitrogen 3 times,The mixture was heated to 100 ¡ã C for 4 hours. After the reaction solution is cooled to room temperature,Diluted with ethyl acetate (50 mL) and the organic phase was washed with brine.Dry over anhydrous sodium sulfate, filter, and the filtrate was evaporated.The residue was purified by EtOAc EtOAc EtOAc EtOAcYield 6-((3S,5R)-3,5-dimethylpiperazin-1-yl)-3,4-dihydroisoquinoline-2(1H)-tert-butyl carboxylic acid (330 mg, yellow solid, yield: 99.79percent)., 21655-48-1

The synthetic route of 21655-48-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Beijing Yue Zhi Kangtai Bio-pharmaceutical Technology Co., Ltd.; Duan Maosheng; Xiong Yanlin; Liu Jiale; Tian Shihong; Dai Quan; (57 pag.)CN109232533; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21655-48-1, cis-2,6-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[7261 Step 1: Synthesis of (3R.55?)- 1 -benzyl-3 .5-dimethvlpiperazine [7271 (2S,6R)-2,6-dimethylpiperazine (1.000 g, 8.757 mmol) and K2C03(1.724 g, 13.136 mmol) were dissolved in acetonitrile (5OmL), and benzylbromide (1.092 mL, 9.195 mmol) was added thereto at 0 ¡ãC, and the mixture was stuffed at the same temperature for 1 hour and 30 minutes. Water was added to the reaction mixture, followed by extraction with ethyl acetate. The organic layer was washed with a saturated aqueous solution of sodium chloride, dried with anhydrous magnesium sulfate, and then concentrated under reduced pressure. The concentrate was purified by column chromatography (silicon dioxide; methanol/methylene chloride = 5 percent) and concentrated to afford the desired compound (1.170 g, 65.4 percent) as a yellow oil., 21655-48-1

The synthetic route of 21655-48-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; SONG, Hyeseung; LEE, Changgon; KWAK, Dalyong; LEE, Jaeyoung; BAE, Suyeal; KIM, Yuntae; BAE, Daekwon; HA, Nina; BAE, Miseon; KIM, Jihyun; WO2015/137750; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics