Category: 21416-67-1

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21416-67-1,4,4′-(Propane-1,2-diyl)bis(piperazine-2,6-dione),as a common compound, the synthetic route is as follows.

21416-67-1, EXAMPLE 1 dl-1,2-Bis(4-morpholinomethyl-3,5-dioxopiperazin-1-yl)-propane A mixture of dl-1,2-bis(3,5-dioxopiperazin-1-yl)-propane (26.8 g, 0.1 mole), morpholine (27 ml, 0.3 mole) and absolute ethanol (100 ml) was heated to reflux. To the mixture, 37% aqueous formaldehyde solution (27 ml) was added gradually and then the reaction mixture was refluxed for further 15 minutes. The cooled mixture was filtered and the filtrate was allowed to stand in the refrigerator. Then resulting white crystals were collected and washed with ethyl acetate to give the titled compound (39.6 g; yield 84.9%). Melting Point: 163 to 165 C. (recrystallized from ethyl acetate). Elementary Analysis (%). Calculated for C21 H34 N6 O6: C 54.06; H 7.35; N 18.01. Found: C 54.28; H 7.58; N 18.05.

As the paragraph descriping shows that 21416-67-1 is playing an increasingly important role.

Reference：
Patent; Zenyaki Kogyo Kabushiki Kaisha; US4737497; (1988); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21416-67-1,4,4′-(Propane-1,2-diyl)bis(piperazine-2,6-dione),as a common compound, the synthetic route is as follows.

21416-67-1, EXAMPLE 1 dl-1,2-Bis(4-morpholinomethyl-3,5-dioxopiperazin-1-yl)-propane A mixture of dl-1,2-bis(3,5-dioxopiperazin-1-yl)-propane (26.8 g, 0.1 mole), morpholine (27 ml, 0.3 mole) and absolute ethanol (100 ml) was heated to reflux. To the mixture, 37% aqueous formaldehyde solution (27 ml) was added gradually and then the reaction mixture was refluxed for further 15 minutes. The cooled mixture was filtered and the filtrate was allowed to stand in the refrigerator. Then resulting white crystals were collected and washed with ethyl acetate to give the titled compound (39.6 g; yield 84.9%). Melting Point: 163 to 165 C. (recrystallized from ethyl acetate). Elementary Analysis (%). Calculated for C21 H34 N6 O6: C 54.06; H 7.35; N 18.01. Found: C 54.28; H 7.58; N 18.05.

As the paragraph descriping shows that 21416-67-1 is playing an increasingly important role.

Reference£º
Patent; Zenyaki Kogyo Kabushiki Kaisha; US4737497; (1988); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21416-67-1, 4,4′-(Propane-1,2-diyl)bis(piperazine-2,6-dione) is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

At the beginning of each working day the capillary was flushed with NaOH 0.1M for 10min, 5min with Milli-Q water and 40min with the buffer in basic conditions and with MeOH for 5min, NaOH 1M for 25min, 5 min with Milli-Q water, 5min with HCl 0.1M and 30min with the buffer in acid conditions. In order to ensure the repeatability between injections, the capillary was flushed with NaOH 0.1M for 5min, 5min with the buffer and 2min with the BGE in basic or acid conditions. Buffer solutions were prepared by dissolving the appropriate amount of formic acid, acetic acid, ammonium bicarbonate or boric acid in Milli-Q water, adjusting the pH to the desired value (pH 2.5, 5.0, 7.0, or 9.0, respectively) with 0.1 or 1M NaOH before completing the volume with water to get the desired buffer concentration. Finally, BGEs were prepared by dissolving the appropriate amount of the chiral selectors in the buffer solution. Stock standard solutions of racemic captopril, econazole and clenbuterol were prepared by dissolving the appropriate amount of these drugs in MeOH and razoxane was prepared by dissolving the appropriate amount in Milli-Q water/25% DMF (v/v). These solutions were stored at 4C. All solutions (buffers and standards) were filtered through 0.45mum pore size nylon membrane filters before their injection in the CE system., 21416-67-1

The synthetic route of 21416-67-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Quintana, Sara; Garcia, Maria Angeles; Marina, Maria Luisa; Gomez, Rafael; de la Mata, F. Javier; Ortega, Paula; Tetrahedron Asymmetry; vol. 28; 12; (2017); p. 1797 – 1802;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics