Category: 21091-98-5piperazines

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21091-98-5,(4-Methylpiperazin-1-yl)(4-nitrophenyl)methanone,as a common compound, the synthetic route is as follows.

Step: 3A-2Synthesis of (4- Amino-phenyl)-(4-methy 1-piperazin-l – l)-methanone.Procedure:Pd-C (150mg) was added to a solution of (4-Methyl-piperazin-l-yl)-(4-nitro-phenyl)- methanone (440mg, 1.7670mmol) in MeOH and stirred for 2hrs in a hydrogen atmosphere. The reaction was monitored by the TLC (10% MeOH: CHC13). The resultant was filtered through celite bed and concentrated to afford 380mg (98% yield) of (4-Amino-phenyl)-(4- methyl-piperazin- 1 -y l)-methanone., 21091-98-5

As the paragraph descriping shows that 21091-98-5 is playing an increasingly important role.

Reference£º
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; SENGUPTA, Saumitra; RAJAGOPALAN, Srinivasan; BELAVAGI, Ningaraddi; RAMACHANDRA, Muralidhara; WO2012/59932; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21091-98-5,(4-Methylpiperazin-1-yl)(4-nitrophenyl)methanone,as a common compound, the synthetic route is as follows.

Step 2: (4-Amino-phenyl)-(4-methy -piperazine-l-yl)-methanoneTo a solution of (4-Methyl-piperazin-l-yl)-(4-nitro-phenyl)-methanone (14 g, 0.05623 mol) in MeOH (100 mL) was added Pd/C 10% (1.4 g) in portions and the Parr reaction vessel was purged with nitrogen for 10 min. reaction vessel was fixed in Pan- shaker at 60 psi pressure for 3 h. The reaction mixture was filtered through the Celite pad and the filtrate was concentrated under reduced pressure to afford the title compound [11 g, 89%]; LC-MS (ESI): Calculated mass 219.1; Observed mass: 220.1 [M+H]+ (RT: 0.16 min).

21091-98-5, 21091-98-5 (4-Methylpiperazin-1-yl)(4-nitrophenyl)methanone 716396, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ENDO PHARMACEUTICALS INC.; SMITH, Roger, Astbury; THOMPSON, Scott, Kevin; HOSAHALLI, Subramanya; BEJUGAM, Mallesham; NANDURI, Srinivas; PANIGRAHI, Sunil, Kumar; MAHALINGAM, Natarajan; WO2012/58671; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics