Category: 21091-98-5

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21091-98-5,(4-Methylpiperazin-1-yl)(4-nitrophenyl)methanone,as a common compound, the synthetic route is as follows.

General procedure: To a stirring solution of compound 4a (1.2g, 4.77mmol) in 70% ethanol (20mL) were added ammonium chloride (1.28g, 23.85mmol) and reduced iron powder (0.8g, 14.31mmol). The reaction was refluxed for 5h. Upon completion, the mixture was filtered while hot and rinsed with ethyl acetate. The solvent was removed in vacuo, and the residue was purified by silica gel column chromatography (PE : EA=1 : 2) to afford compound 5a as an orange solid.

21091-98-5, The synthetic route of 21091-98-5 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Heng, Hao; Wang, Zhijie; Li, Hongmei; Huang, Yatian; Lan, Qingyuan; Guo, Xiaoxing; Zhang, Liang; Zhi, Yanle; Cai, Jiongheng; Qin, Tianren; Xiang, Li; Wang, Shuxian; Chen, Yadong; Lu, Tao; Lu, Shuai; European Journal of Medicinal Chemistry; vol. 176; (2019); p. 248 – 267;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21091-98-5,(4-Methylpiperazin-1-yl)(4-nitrophenyl)methanone,as a common compound, the synthetic route is as follows.

General procedure: To a stirring solution of compound 4a (1.2g, 4.77mmol) in 70% ethanol (20mL) were added ammonium chloride (1.28g, 23.85mmol) and reduced iron powder (0.8g, 14.31mmol). The reaction was refluxed for 5h. Upon completion, the mixture was filtered while hot and rinsed with ethyl acetate. The solvent was removed in vacuo, and the residue was purified by silica gel column chromatography (PE : EA=1 : 2) to afford compound 5a as an orange solid.

21091-98-5, The synthetic route of 21091-98-5 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Heng, Hao; Wang, Zhijie; Li, Hongmei; Huang, Yatian; Lan, Qingyuan; Guo, Xiaoxing; Zhang, Liang; Zhi, Yanle; Cai, Jiongheng; Qin, Tianren; Xiang, Li; Wang, Shuxian; Chen, Yadong; Lu, Tao; Lu, Shuai; European Journal of Medicinal Chemistry; vol. 176; (2019); p. 248 – 267;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21091-98-5,(4-Methylpiperazin-1-yl)(4-nitrophenyl)methanone,as a common compound, the synthetic route is as follows.

(4-Methyl-piperazin- l-yl)-(4-nitro-phenyl)-methanone (2.12 g, 8.51 mmol) was dissolved in Methanol (35 mL, 860 mmol) and the solution was carefull added to a Parr vessel containing 10% Palladium on Carbon (0.650 g, 48.7 mmol) under nitrogen. The mixture was then placed on a Parr hydrogenation apparatus and was allowed to shake at 55 psi until uptake of hydrogen ceased. The catalyst was then filtered to afford 1.86 g of (4-Amino-phenyl)-(4-methyl-piperazin-l-yl)-methanone without further purification. (M+H) = 220.6. 1H NMR (400 MHz, DMSO, d6) delta 7.09 (d, 2H, J = 8.41 Hz), 6.53 (d, 2H J = 8.41 Hz), 5.48 (s, 2H), 3.46 (m, 4H), 2.28 (m, 4H), 2.17 (s, 3H).

21091-98-5, As the paragraph descriping shows that 21091-98-5 is playing an increasingly important role.

Reference：
Patent; CEPHALON, INC.; BRESLIN, Henry J.; CHATTERJEE, Sankar; DIEBOLD, James L.; DORSEY, Bruce D.; DUNN, Derek; GINGRICH, Diane E.; HOSTETLER, Greg A.; HUDKINS, Robert L.; HUNTER, Rachael; JOSEF, Kurt; LISKO, Joseph; MESAROS, Eugen F.; MILKIEWICZ, Karen L.; OTT, Gregory R.; SUNDAR, Babu G.; THEROFF, Jay P.; THIEU, Tho; TRIPATHY, Rabindranath; UNDERINER, Theodore L.; WEINBERG, Linda; WELLS, Gregory J.; ZIFICSAK, Craig A.; WO2010/71885; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21091-98-5, (4-Methylpiperazin-1-yl)(4-nitrophenyl)methanone is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(4-Methylpiperazin-1-yl)(4-nitrophenyl)methanone (31.5 g, 126 mmol) was dissolved in methanol (150 ml) and transferred into a 500-ml PARR flask. The PARR flask was flushed with nitrogen, then 500 mg Pd/C (10% Pd) were added. The flask was flushed with nitrogen, then hydrogen, then shaken under a pressure of 50 psi of hydrogen for 17 hours. The mixture was filtered through CELITE, the solid washed with MeOH and concentrated to give 27.2 g beige solid ((4-aminophenyl)(4- methylpiperazin-1-yl)methanone. MS (ESI) m/z 220 (M+H). 1H NMR (CDCl3) delta ppm 7.25 (d, 2 H, J= 7.6), 6.64 (d, 2 H, J= 7.6), 3.86 (bs, 2 H), 3.63 (bs, 4 H), 2.40 (bs, 4H), 2.30 (s, 3H)., 21091-98-5

21091-98-5 (4-Methylpiperazin-1-yl)(4-nitrophenyl)methanone 716396, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; BRISTOL-MYERS SQUIBB COMPANY; PURANDARE, Ashok, Vinayak; BATT, Douglas, G.; LIU, Qingjie; JOHNSON, Walter, L.; MASTALERZ, Harold; ZHANG, Guifen; ZIMMERMANN, Kurt; WO2010/80474; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21091-98-5, (4-Methylpiperazin-1-yl)(4-nitrophenyl)methanone is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(4-Methylpiperazin-1-yl)(4-nitrophenyl)methanone (31.5 g, 126 mmol) was dissolved in methanol (150 ml) and transferred into a 500-ml PARR flask. The PARR flask was flushed with nitrogen, then 500 mg Pd/C (10% Pd) were added. The flask was flushed with nitrogen, then hydrogen, then shaken under a pressure of 50 psi of hydrogen for 17 hours. The mixture was filtered through CELITE, the solid washed with MeOH and concentrated to give 27.2 g beige solid ((4-aminophenyl)(4- methylpiperazin-1-yl)methanone. MS (ESI) m/z 220 (M+H). 1H NMR (CDCl3) delta ppm 7.25 (d, 2 H, J= 7.6), 6.64 (d, 2 H, J= 7.6), 3.86 (bs, 2 H), 3.63 (bs, 4 H), 2.40 (bs, 4H), 2.30 (s, 3H)., 21091-98-5

21091-98-5 (4-Methylpiperazin-1-yl)(4-nitrophenyl)methanone 716396, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; BRISTOL-MYERS SQUIBB COMPANY; PURANDARE, Ashok, Vinayak; BATT, Douglas, G.; LIU, Qingjie; JOHNSON, Walter, L.; MASTALERZ, Harold; ZHANG, Guifen; ZIMMERMANN, Kurt; WO2010/80474; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21091-98-5,(4-Methylpiperazin-1-yl)(4-nitrophenyl)methanone,as a common compound, the synthetic route is as follows.

To 1.67 g (6.70 mmol) of the product prepared in step 2.1 partially dissolved in 50 mL of methanol are added, under an inert atmosphere, 71 mg of 10% palladium-on-charcoal. The reaction mixture is stirred at room temperature under 3 bar of hydrogen for 2 hours 30 minutes and then filtered through Celite. After evaporating to dryness, 1.5 g of the expected product are obtained in the form of an orange oil, which is used as obtained in the following step. Quantitative yield., 21091-98-5

21091-98-5 (4-Methylpiperazin-1-yl)(4-nitrophenyl)methanone 716396, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; SANOFI; US2012/277220; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21091-98-5, (4-Methylpiperazin-1-yl)(4-nitrophenyl)methanone is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 3a (1.20 g, 4.81mmol) and Pd/C (0.102 g, 0.096 mmol) in MeOH (25 mL) was stirred under H2 overnight.The suspension was filtered through a pad of Celite and the pad was washed with EtOH(10 mL¡Á3). The combined filtrates were concentrated and the crude was purified bycolumn chromatography on silica gel (DCM: MeOH =20:1) to give the title compound3b (1.0 g, 95 % yield). LCMS: 220.1 [M+H]+., 21091-98-5

The synthetic route of 21091-98-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ding, Xiao; Stasi, Luigi Piero; Ho, Ming-Hsun; Zhao, Baowei; Wang, Hailong; Long, Kai; Xu, Qiongfeng; Sang, Yingxia; Sun, Changhui; Hu, Huan; Yu, Haihua; Wan, Zehong; Wang, Lizhen; Edge, Colin; Liu, Qian; Li, Yi; Dong, Kelly; Guan, Xiaoming; Tattersall, F. David; Reith, Alastair D.; Ren, Feng; Bioorganic and Medicinal Chemistry Letters; vol. 28; 9; (2018); p. 1615 – 1620;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics