Category: 197638-83-8

Nishizawa, Akihiro; Takahira, Tsuyoshi; Yasui, Kosuke; Fujimoto, Hayato; Iwai, Tomohiro; Sawamura, Masaya; Chatani, Naoto; Tobisu, Mamoru published the artcile< Nickel-Catalyzed Decarboxylation of Aryl Carbamates for Converting Phenols into Aromatic Amines>, Recommanded Product: 1-Boc-4-(4-Formylphenyl)piperazine, the main research area is phenol conversion aromatic amine nickel catalyzed decarboxylation carbamate; polystyrene supported phosphine ligand nickel catalyzed decarboxylation carbamate.

Herein, we describe a new catalytic approach to accessing aromatic amines from an abundant feedstock, namely phenols. The most reliable catalytic method for converting phenols to aromatic amines uses an activating group, such as a trifluoromethane sulfonyl group. However, this activating group is eliminated as a leaving group during the amination process, resulting in significant waste. Our nickel-catalyzed decarboxylation reaction of aryl carbamates forms aromatic amines with carbon dioxide as the only byproduct. As this amination proceeds in the absence of free amines, a range of functionalities, including a formyl group, are compatible. A bisphosphine ligand immobilized on a polystyrene support (PS-DPPBz) is key to the success of this reaction, generating a catalytic species that is significantly more active than simple nonsupported variants.

Journal of the American Chemical Societypublished new progress about Amination (decarboxylative amination). 197638-83-8 belongs to class piperazines, and the molecular formula is C16H22N2O3, Recommanded Product: 1-Boc-4-(4-Formylphenyl)piperazine.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Bhattacharyya, Bhaswati; Dhara, Kaliprasanna published the artcile< Highly efficient, mild, one pot synthesis of 2-substituted benzimidazoles, benzothiazoles and pyridoimidazoles promoted by N-iodosuccinimide>, Recommanded Product: 1-Boc-4-(4-Formylphenyl)piperazine, the main research area is benzimidazole benzothiazole imidazopyridine preparation.

A common and highly efficient metal-free route for the synthesis of 2-substituted benzimidazoles, benzothiazoles and pyridoimidazoles from suitable 1,2- functionalized aromatic compounds and various aromatic and aliphatic aldehydes and ferrocenecarboxaldehyde was developed using 1-iodo-2,5-pyrrolidinedione, (N-iodosuccinimide) as the oxidizing agent. The methodol. involved very short reaction time, mild reaction procedure and easy work-up as well as excellent yields of the products. The synthesis of the target compounds was achieved by a reaction of 1,2-benzenediamine, 2-aminobenzenethiol, 2,3-pyridinediamine with aldehydes, such as benzaldehyde derivatives, 4-formylbenzonitrile, 1,3-benzodioxole-5-carboxaldehyde, citronellal, (formyl)ferrocene. The title compounds thus formed included 2-phenyl-1H-benzimidazole, 2-phenylbenzothiazole, (4-methyl-1H-benzimidazol-2-yl)ferrocene, 2-phenyl-3H-imidazo[4,5-b]pyridine derivatives

Journal of the Indian Chemical Societypublished new progress about Aliphatic aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 197638-83-8 belongs to class piperazines, and the molecular formula is C16H22N2O3, Recommanded Product: 1-Boc-4-(4-Formylphenyl)piperazine.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Papagni, Antonio; Del Buttero, Paola; Bertarelli, Chiara; Miozzo, Luciano; Moret, Massimo; Pryce, Mary T.; Rizzato, Silvia published the artcile< Novel fluorinated amino-stilbenes and their solid-state photodimerization>, Reference of 197638-83-8, the main research area is fluorinated aminostilbene solid state photodimerization.

We synthesized a series of polyfluoroaminostilbenes in satisfactory yields by Wittig reaction of 4-piperazinylbenzalhehydes with pentafluorobenzylidenetriphenylphosphorane and we analyzed the photochem. behavior of these stilbenes in the solid state; thanks to arene-perfluoroarene π-π interactions, some of them have shown a good propensity to give the corresponding cyclobutane photodimers in quant. yields. The photocyclization is reversible both in solution and in polymeric matrix, affording the corresponding stilbenes with different cis-trans stereoselectivity.

New Journal of Chemistrypublished new progress about [2+2] Photocycloaddition reaction. 197638-83-8 belongs to class piperazines, and the molecular formula is C16H22N2O3, Reference of 197638-83-8.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.197638-83-8,1-Boc-4-(4-Formylphenyl)piperazine,as a common compound, the synthetic route is as follows.

Synthesis of 4-(4-morpholin-4-ylmethyl-phenyl)-piperazine-1-carboxylic acid tert- butyl ester (2). A mixture of compound (1) (342 mg, 1.18 mmol), NaBH(OAc)3 (300 mg, 1.42 mmol) and morpholine (113 mul, 1.3 mmol) in DCM (5 ml) was stirred at ambient temperature overnight. Reaction was quenched with 5% aq. NaHCO3 (15 ml) and extracted with EtOAc (30 ml x 2). Organic layer was washed with brine (20 ml) and dried over MgSO4 (anh.). Solvent was evaporated in vacuum. Residue was dried in vacuum overnight to provide target compound (2) (408 mg, 96%) as white solid. LC-MS [M+H] 361.9 (C20H3 iN3O3+H, requires 362.50).

197638-83-8, The synthetic route of 197638-83-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; ACHAOGEN, INC.; WO2008/154642; (2008); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.197638-83-8,1-Boc-4-(4-Formylphenyl)piperazine,as a common compound, the synthetic route is as follows.

Synthesis of 4-(4-morpholin-4-ylmethyl-phenyl)-piperazine-1-carboxylic acid tert- butyl ester (2). A mixture of compound (1) (342 mg, 1.18 mmol), NaBH(OAc)3 (300 mg, 1.42 mmol) and morpholine (113 mul, 1.3 mmol) in DCM (5 ml) was stirred at ambient temperature overnight. Reaction was quenched with 5% aq. NaHCO3 (15 ml) and extracted with EtOAc (30 ml x 2). Organic layer was washed with brine (20 ml) and dried over MgSO4 (anh.). Solvent was evaporated in vacuum. Residue was dried in vacuum overnight to provide target compound (2) (408 mg, 96%) as white solid. LC-MS [M+H] 361.9 (C20H3 iN3O3+H, requires 362.50).

197638-83-8, The synthetic route of 197638-83-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; ACHAOGEN, INC.; WO2008/154642; (2008); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.197638-83-8,1-Boc-4-(4-Formylphenyl)piperazine,as a common compound, the synthetic route is as follows.

Example 26 te/t-butyl 4-(4-(6-Bromo-7-(4-(1-phenylethyl)piperazin-1-yl)-3H-imidazo[4,5-jb]pyridin- 2-yl)phenyl)piperazine-1-carboxylate To a mixture of 5-bromo-3-nitro-4-[4-(1-phenyl-ethyl)-piperazin-1-yl]-pyridin-2-ylamine (prepared as described in example 70 of PCT/GB2006/004854; 0.042 g, 0.1 mmol) and EtOH (6.5 ml_) was added ferf-butyl 4-(4-formylphenyl)piperazine-1-carboxylate (0.038 g, 0.13 mmol) followed by a freshly prepared aqueous solution of Na2S2O4 (1 M; 0.40 mL, 0.40 mmol). The reaction mixture was stirred at 80 0C for 20 h, then allowed to cool to room temperature and concentrated in vacuo. The residue was absorbed on silica gel, the free-running powder was placed on a 10 g isolute silica column, and elution with a gradient of methanol (0 to 3%) in ethyl acetate / dichloromethane (v:v; 1 :1 ) afforded the title compound as a yellow solid (0.031 g, 48%). 1H-NMR (500 MHz, DMSO-d6) 1.36 (d, J = 6.7 Hz, 3H, CHCH3), 1.43 (s, 9H, OC(CHs)3), 2.53 (m, 2H), 2.60 (m, 2H), 3.26 (br t, 4H), 3.48 (m, 5H), and 3.61 (br s, 4H) (piperazine NCH2 and CHCH3), 7.07 (d, J = 9.0 Hz, 2H) and 8.03 (d, J = 8.8 Hz, 2H) (2,6-C6H4 and 3,5-C6H4), 7.25 (m, 1 H) and 7.36 (m, 4H) (PhH), 8.15 (s, 1 H, imidazo[4,5-]pyridine 5-H), 13.23 (br s, 1 H, imidazo[4,5-]pyridine N-H); LC (Method B) – MS (ESI, m/z): Rt = 4.14 min – 646, 648, [(M+H)+, Br isotopic pattern],

197638-83-8, 197638-83-8 1-Boc-4-(4-Formylphenyl)piperazine 2795509, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; CHROMA THERAPEUTICS LTD.; WO2009/1021; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.197638-83-8,1-Boc-4-(4-Formylphenyl)piperazine,as a common compound, the synthetic route is as follows.

Example 26 te/t-butyl 4-(4-(6-Bromo-7-(4-(1-phenylethyl)piperazin-1-yl)-3H-imidazo[4,5-jb]pyridin- 2-yl)phenyl)piperazine-1-carboxylate To a mixture of 5-bromo-3-nitro-4-[4-(1-phenyl-ethyl)-piperazin-1-yl]-pyridin-2-ylamine (prepared as described in example 70 of PCT/GB2006/004854; 0.042 g, 0.1 mmol) and EtOH (6.5 ml_) was added ferf-butyl 4-(4-formylphenyl)piperazine-1-carboxylate (0.038 g, 0.13 mmol) followed by a freshly prepared aqueous solution of Na2S2O4 (1 M; 0.40 mL, 0.40 mmol). The reaction mixture was stirred at 80 0C for 20 h, then allowed to cool to room temperature and concentrated in vacuo. The residue was absorbed on silica gel, the free-running powder was placed on a 10 g isolute silica column, and elution with a gradient of methanol (0 to 3%) in ethyl acetate / dichloromethane (v:v; 1 :1 ) afforded the title compound as a yellow solid (0.031 g, 48%). 1H-NMR (500 MHz, DMSO-d6) 1.36 (d, J = 6.7 Hz, 3H, CHCH3), 1.43 (s, 9H, OC(CHs)3), 2.53 (m, 2H), 2.60 (m, 2H), 3.26 (br t, 4H), 3.48 (m, 5H), and 3.61 (br s, 4H) (piperazine NCH2 and CHCH3), 7.07 (d, J = 9.0 Hz, 2H) and 8.03 (d, J = 8.8 Hz, 2H) (2,6-C6H4 and 3,5-C6H4), 7.25 (m, 1 H) and 7.36 (m, 4H) (PhH), 8.15 (s, 1 H, imidazo[4,5-]pyridine 5-H), 13.23 (br s, 1 H, imidazo[4,5-]pyridine N-H); LC (Method B) – MS (ESI, m/z): Rt = 4.14 min – 646, 648, [(M+H)+, Br isotopic pattern],

197638-83-8, 197638-83-8 1-Boc-4-(4-Formylphenyl)piperazine 2795509, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; CHROMA THERAPEUTICS LTD.; WO2009/1021; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

197638-83-8, 1-Boc-4-(4-Formylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,197638-83-8

Compound 23 was synthesized as show n Scheme 4.

The synthetic route of 197638-83-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; COMBS, Colin; MULLER, Gerhard; DAMEN, Eddy; NAGAMOTO-COMBS, Kumi; (73 pag.)WO2017/100703; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

197638-83-8, 1-Boc-4-(4-Formylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 19 terf-Butyl 4-(4-(6-bromo-7-(4-(4-chlorobenzyl)piperazin-1-yl)-3H-imidazo[4,5- b]pyridin-2-yl)benzyl)piperazine-1-carboxylate To a mixture of 5-bromo-4-[4-(4-chloro-benzyl)-piperazin-1-yl]-3-nitro-pyridin-2- ylamine (0.043 g, 0.10 mmol) and EtOH (6.0 mL) was added tert-butyl 4-(4- formylbenzyl)piperazine-1-carboxylate (0.040 g, 0.13 mmol) followed by a freshly prepared aqueous solution of Na2S2theta4 (1 M; 0.40 mL, 0.40 mmol). The reaction mixture was stirred at 80 0C for 24 h, then allowed to cool to room temperature and concentrated in vacuo. The residue was absorbed on silica gel, the free-running powder was placed on a 10 g isolute silica column, and elution with a gradient of methanol (0 to 7%) in ethyl acetate / dichloromethane (v:v; 1 :1 ) afforded the title compound as a pale yellow solid (0.036 g, 53%). 1H-NMR (500 MHz, DMSO-d6) 1.39 (s, 9H, OC(CH3)3), 2.33 (br t, J = 4.7 Hz, 4H), 2.61 (br s, 4H), 3.33 (br s, 4H), 3.67 (br s, 4H) (4 x piperazine N(CH2)2), 3.56 (s, 2H) and 3.57 (s, 2H) (NCH2-C6H4CI and C6H4CH2, 7.41 (m, 4 H, C6H4CI), 7.47 (d, J = 7.6 Hz, 2H) and 8.14 (d, J = 7.6 Hz, 2H) (3,5-C6H4 and 2,6-C6H4), 8.23 (s, 1 H, imidazo[4,5-197638-83-8, As the paragraph descriping shows that 197638-83-8 is playing an increasingly important role.

Reference：
Patent; CHROMA THERAPEUTICS LTD.; WO2009/1021; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

197638-83-8, 1-Boc-4-(4-Formylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,197638-83-8

Compound 23 was synthesized as show n Scheme 4.

The synthetic route of 197638-83-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; COMBS, Colin; MULLER, Gerhard; DAMEN, Eddy; NAGAMOTO-COMBS, Kumi; (73 pag.)WO2017/100703; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics