Category: 192330-11-3

192330-11-3, (R)-1-Boc-Piperazine-3-carboxylic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 110(“i?V4-r2-(2-Fluoro-4-iodophenylaminoV5,5-dimethyl-8-oxo-5,6.7.8-tetrahvdro-4H- thieno[2,3-c]azepin-3-ylcarbonyl1piperaziiie-l,3-dicarboxylic acid; 1-fert-butyl ester triethylamine salt(i?)-4-N-tert-Butoxycarbonylpiperazine-2-carboxylic acid (346 mg, 1.50 mmol) was added to a solution of Intermediate 5 (300 mg, 0.46 mmol) and triethylamine (0.33 mL, 2.3 mmol) in DCM (8 mL). The mixture was stirred at room temperature for 18 h. Water (75 mL) was added and the mixture extracted with DCM (3 x 100 mL). The combined organic extracts were washed with brine (100 mL), dried (MgSO4), filtered and concentrated in vacuo. The crude product was purified by chromatography (silica, 0-10% methanol in DCM) to give the title compound as a white solid (266 mg, 74%). LCMS (ES+) RT 2.72 minutes, 687.1 (M+H)+., 192330-11-3

The synthetic route of 192330-11-3 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; UCB PHARMA S.A.; WO2008/20206; (2008); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.192330-11-3,(R)-1-Boc-Piperazine-3-carboxylic acid,as a common compound, the synthetic route is as follows.

Prep(167a): (21(at)-4-(tert-butoxycarbonyl)-1-(cyclopentylmethyl)piperazine-2-carboxylic acid In a round bottom flask, (2R)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid (1.50 g, 6.52 mmol) in THF (20 mL) was dissolved, then cyclopentanecarbaldehyde (0.70 mL, 7.62 mmol) with acetic acid (1.20 mL) was added and then stirred for 0.5 hours. Next, NaBH(OAc)3 (2.07 g, 9.77 mmol) was added over 5 minutes and then stirred for 12 hours. The mixture was filtered though a cellose filter. The mother liquid was concentrated and placed on the high vacuum to afford (2R)-4-(tert-butoxycarbonyl)-1- (cyclopentylmethyl)piperazine-2-carboxylic acid as a white solid (1.98 g, 97.4%). 1 H NMR (400 MHz, DMSO-d6) No. ppm: 3.48-3.40 (m, 1 H), 3.36-3.25 (m, 2H), 3.12-3.00 (m, 2H), 2.28-2.24 (m, 1 H), 2.17 (bs, 1H), 2.08-2.08-2.01 (m, 1H), 1.69-1.59 (m, 2H), 1.55-1.44 (m, 4H), 1.38 (s, 9H), 1.35-1.20 (m, 2H), 1.14- 1.06 (m, 1 H). LCMS (ESI) : m/z. 313.2., 192330-11-3

192330-11-3 (R)-1-Boc-Piperazine-3-carboxylic acid 6558430, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; PFIZER INC.; WO2005/108359; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics