185110-19-4, 2-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step 3: (+/-)-Methyl {3-[4-(trifluoromethyl)phenyl]piperazin-l-yl} acetate; A mixture of the piperazine described in Step 2 above (2.1g, 9mmol), methyl bromoacetate (ImL, 9mmol) and potassium carbonate (2.4g, 18mmol) in acetonitrile (3OmL) was stirred overnight at room temperature. The mixture was filtered, evaporated and purified on silica using 25-50% ethyl acetate in z’s¡ã-hexane as eluant.1H NMR (500MHz, CDCl3): delta 2.22 (IH, t, J 10.6), 2.37-2.43 (IH, m), 2.93 (2H, t, J 9.4), 3.10- 3.17 (2H, m), 3.26 (2H, s), 3.72 (3H, s), 7.52 (2H, d, J 8.1), 7.58 (2H, d, J 8.2).
185110-19-4, The synthetic route of 185110-19-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MERCK SHARP & DOHME LIMITED; MERCK & CO., INC.; WO2007/125364; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics