Formula: C20H24FN3O4On October 31, 2012 ,《A digitized impurity database analysis method for determining the impurity profiles of gatifloxacin in bulk materials and injections》 appeared in Pharmazie. The author of the article were Zhang, Dousheng; Chang, Yan; Li, Yaping; Yao, Shangchen; Hu, Changqin. The article conveys some information:
HPLC has become the most important anal. technique for impurity profiling to assure the quality of pharmaceutical products. Although HPLC is considered as a well-established technol., it requires CRS (chem. reference substances) of impurities for qualification and quantification of impurity peaks. Many impurity CRS were widely used for the impurity profile control, which causes a high cost of production in practice. In this study, we developed a new method for impurity profiling control, so called digitized impurity database anal., which does not directly use impurity CRS. Using a quinolone antibiotic, gatifloxacin as an example, we 1st analyzed its impurities by DAD (diode array detector) to compile a digitized impurity database and then used the database to analyze the impurities in the samples of domestic gatifloxacin bulk materials and injections in China. We identified the impurities in the chromatogram by combining 2-dimensional chromatog. spectral correlation analyses of UV spectra data and relative retention times. The content of the impurities was determined using relative response factors of impurity to gatifloxacin as normalization factors. The digital impurity database anal. technol. we developed is a “”green””, economic and convenient method that may eliminate the use of impurity CRS in the impurity profile control. In the part of experimental materials, we found many familiar compounds, such as 1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0Formula: C20H24FN3O4)
1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Formula: C20H24FN3O4
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics