Zhang, Dousheng’s team published research in Pharmazie in 2012 | CAS: 182868-72-0

1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Formula: C20H24FN3O4

Formula: C20H24FN3O4On October 31, 2012 ,《A digitized impurity database analysis method for determining the impurity profiles of gatifloxacin in bulk materials and injections》 appeared in Pharmazie. The author of the article were Zhang, Dousheng; Chang, Yan; Li, Yaping; Yao, Shangchen; Hu, Changqin. The article conveys some information:

HPLC has become the most important anal. technique for impurity profiling to assure the quality of pharmaceutical products. Although HPLC is considered as a well-established technol., it requires CRS (chem. reference substances) of impurities for qualification and quantification of impurity peaks. Many impurity CRS were widely used for the impurity profile control, which causes a high cost of production in practice. In this study, we developed a new method for impurity profiling control, so called digitized impurity database anal., which does not directly use impurity CRS. Using a quinolone antibiotic, gatifloxacin as an example, we 1st analyzed its impurities by DAD (diode array detector) to compile a digitized impurity database and then used the database to analyze the impurities in the samples of domestic gatifloxacin bulk materials and injections in China. We identified the impurities in the chromatogram by combining 2-dimensional chromatog. spectral correlation analyses of UV spectra data and relative retention times. The content of the impurities was determined using relative response factors of impurity to gatifloxacin as normalization factors. The digital impurity database anal. technol. we developed is a “”green””, economic and convenient method that may eliminate the use of impurity CRS in the impurity profile control. In the part of experimental materials, we found many familiar compounds, such as 1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0Formula: C20H24FN3O4)

1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Formula: C20H24FN3O4

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Li, Wei’s team published research in Journal of Chromatography A in 2008 | CAS: 182868-72-0

1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Application In Synthesis of 1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Application In Synthesis of 1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acidOn May 9, 2008 ,《Spectral correlation of high-performance liquid chromatography-diode array detection data from two independent chromatographic runs》 appeared in Journal of Chromatography A. The author of the article were Li, Wei; Hu, Chang-qin. The article conveys some information:

A novel qual. anal. method for peak tracking in impurity profiling control by the correlation of spectra was established. Two-dimensional (2D) standard spectrochromatog. data produced by HPLC with diode array detection (HPLC-DAD) were compared with sample data to develop two-dimensional chromatog. spectral correlative maps. Taking full advantage of separation efficiency of HPLC and spectral specificity of the analytes, the method was successfully used to recognize impurities in quinolone antibacterials, when in combination with relative retention times (RRTs). For the comparison of spectra was expanded to three-dimensional space, simultaneous identification of the chromatog. peaks can be obtained rapidly without preparation and injection of a reference solution, even when the mobile phase changed or the peaks of multi-component samples overlapped. In the experiment, the researchers used many compounds, for example, 1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0Application In Synthesis of 1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid)

1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Application In Synthesis of 1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Jaen-Oltra, Jose’s team published research in Journal of Medicinal Chemistry in 2000 | CAS: 182868-72-0

1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Product Details of 182868-72-0

Product Details of 182868-72-0On March 23, 2000, Jaen-Oltra, Jose; Salabert-Salvador, Ma. Teresa; Garcia-March, Francisco J.; Perez-Gimenez, Facundo; Tomas-Vert, Francisco published an article in Journal of Medicinal Chemistry. The article was 《Artificial neural network applied to prediction of fluorquinolone antibacterial activity by topological methods》. The article mentions the following:

A new topol. method that makes it possible to predict the properties of mols. on the basis of their chem. structures is applied in the present study to quinolone antimicrobial agents. This method uses neural networks in which training algorithms are used as well as different concepts and methods of artificial intelligence with a suitable set of topol. descriptors. This makes it possible to determine the minimal inhibitory concentration (MIC) of quinolones. Anal. of the results shows that the exptl. and calculated values are highly similar. It is possible to obtain a QSAR interpretation of the information contained in the network after the training has been carried out.1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0Product Details of 182868-72-0) was used in this study.

1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Product Details of 182868-72-0

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Jaen-Oltra, Jose’s team published research in Journal of Medicinal Chemistry in 2000 | CAS: 182868-72-0

1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Product Details of 182868-72-0

Product Details of 182868-72-0On March 23, 2000, Jaen-Oltra, Jose; Salabert-Salvador, Ma. Teresa; Garcia-March, Francisco J.; Perez-Gimenez, Facundo; Tomas-Vert, Francisco published an article in Journal of Medicinal Chemistry. The article was 《Artificial neural network applied to prediction of fluorquinolone antibacterial activity by topological methods》. The article mentions the following:

A new topol. method that makes it possible to predict the properties of mols. on the basis of their chem. structures is applied in the present study to quinolone antimicrobial agents. This method uses neural networks in which training algorithms are used as well as different concepts and methods of artificial intelligence with a suitable set of topol. descriptors. This makes it possible to determine the minimal inhibitory concentration (MIC) of quinolones. Anal. of the results shows that the exptl. and calculated values are highly similar. It is possible to obtain a QSAR interpretation of the information contained in the network after the training has been carried out.1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0Product Details of 182868-72-0) was used in this study.

1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Product Details of 182868-72-0

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Renau, Thomas E.’s team published research in Antimicrobial Agents and Chemotherapy in 1996 | CAS: 182868-72-0

1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).SDS of cas: 182868-72-0

SDS of cas: 182868-72-0On October 31, 1996 ,《Structure-activity relationships of quinolone agents against mycobacteria: effect of structural modifications at the 8 position》 appeared in Antimicrobial Agents and Chemotherapy. The author of the article were Renau, Thomas E.; Gage, Jeffrey W.; Dever, Julie A.; Roland, Gregory E.; Joannides, E. Themis; Shapiro, Martin A.; Sanchez, Joseph P.; Gracheck, Stephen J.; Domagala, John M.. The article conveys some information:

A series of quinolones with substitutions at the 8 position has been prepared as part of a study to examine the relation between structural modifications at this position and activity against mycobacteria. The compounds were prepared by procedures described in the literature and were evaluated for their activities against Mycobacterium fortuitum and Mycobacterium smegmatis. The activities of the compounds against these two organisms were used as a measure of Mycobacterium tuberculosis activity. The results demonstrate that the contribution of the 8 position to antimycobacterial activity was dependent on the substituent at N-1 and was in the order (i) COMe ≈ CBr > CCl > CH ≈ CF ≈ COEt > N > CCF3 when N-1 was cyclopropyl; (ii) N ≈ CH > CF > COMe when N-1 was 2,4-difluorophenyl; (iii) N ≥ CH when N-1 was tert-butyl; and (i.v.) N > CH when N-1 was Et. In general, derivatives with piperazine substitutions at C-7 were slightly less active against mycobacteria than the analogs with pyrrolidine substitutions, regardless of the pattern of substitution at the 8 position. Several of the best compounds were evaluated for their potential side effects as well as their activities against Mycobacterium aurum, Mycobacterium avium-M. Intracellularle, and M. tuberculosis. These agents exhibited biol. profiles similar to or better than those of the pos. controls ciprofloxacin and sparfloxacin. In addition to this study using 1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, there are many other studies that have used 1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0SDS of cas: 182868-72-0) was used in this study.

1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).SDS of cas: 182868-72-0

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Zhang, Dou-Sheng’s team published research in Journal of Planar Chromatography–Modern TLC in 2013 | CAS: 182868-72-0

1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Related Products of 182868-72-0

Zhang, Dou-Sheng; Liu, Wen; Li, Ya-Ping; Hu, Chang-Qin published an article in Journal of Planar Chromatography–Modern TLC. The title of the article was 《Establishment and optimization of an HPTLC method for the analysis of gatifloxacin and related substances by design of experiment》.Related Products of 182868-72-0 The author mentioned the following in the article:

The objective of this study was to establish and optimize high-performance thin-layer chromatog. (HPTLC) anal. of gatifloxacin and related substances by the method of design of experiment (DOE). First, preliminary screening of 22 solvents was performed using uniform design (UD) to establish the developing solvent proposed to be optimized. The optimal proportions of components in the developing solvent were established by central composite design (CCD) to establish and validate HPTLC anal. of gatifloxacin and related substances. Using DOE, it was found that the optimal proportions (by volume) of components in the developing solvent in the HPTLC anal. method were methanol-1,2-dichloroethane-concentrated ammonia solution-acetonitrile (2.8:7.2:0.5:0.5, ν/ν). Methodol. validation showed that the established HPTLC method could sep. gatifloxacin and 8 related substances with similar structures effectively. In particular, impurity pairs with the greatest separation difficulty (due to their similar polarities and dipole moments), e.g., impurity #3 (8-fluorogatifloxacin) and impurity #8 (gatifloxacin 2-methylpiperazine), impurity #3, and substance #9 (gatifloxacin), could also be separated effectively. The HPTLC method was simple, accurate, reliable, and suitable for rapid qual. anal. of gatifloxacin and related substances in routine tests. Addnl., the anal. results presented here may provide useful supplemental information on the current reversed phase high-performance liquid chromatog. (RP-HPLC) method, especially in terms of the mechanism of normal-phase separation In the experiment, the researchers used many compounds, for example, 1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0Related Products of 182868-72-0)

1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Related Products of 182868-72-0

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Renau, Thomas E.’s team published research in Antimicrobial Agents and Chemotherapy in 1996 | CAS: 182868-72-0

1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).SDS of cas: 182868-72-0

SDS of cas: 182868-72-0On October 31, 1996 ,《Structure-activity relationships of quinolone agents against mycobacteria: effect of structural modifications at the 8 position》 appeared in Antimicrobial Agents and Chemotherapy. The author of the article were Renau, Thomas E.; Gage, Jeffrey W.; Dever, Julie A.; Roland, Gregory E.; Joannides, E. Themis; Shapiro, Martin A.; Sanchez, Joseph P.; Gracheck, Stephen J.; Domagala, John M.. The article conveys some information:

A series of quinolones with substitutions at the 8 position has been prepared as part of a study to examine the relation between structural modifications at this position and activity against mycobacteria. The compounds were prepared by procedures described in the literature and were evaluated for their activities against Mycobacterium fortuitum and Mycobacterium smegmatis. The activities of the compounds against these two organisms were used as a measure of Mycobacterium tuberculosis activity. The results demonstrate that the contribution of the 8 position to antimycobacterial activity was dependent on the substituent at N-1 and was in the order (i) COMe ≈ CBr > CCl > CH ≈ CF ≈ COEt > N > CCF3 when N-1 was cyclopropyl; (ii) N ≈ CH > CF > COMe when N-1 was 2,4-difluorophenyl; (iii) N ≥ CH when N-1 was tert-butyl; and (i.v.) N > CH when N-1 was Et. In general, derivatives with piperazine substitutions at C-7 were slightly less active against mycobacteria than the analogs with pyrrolidine substitutions, regardless of the pattern of substitution at the 8 position. Several of the best compounds were evaluated for their potential side effects as well as their activities against Mycobacterium aurum, Mycobacterium avium-M. Intracellularle, and M. tuberculosis. These agents exhibited biol. profiles similar to or better than those of the pos. controls ciprofloxacin and sparfloxacin. In addition to this study using 1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, there are many other studies that have used 1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0SDS of cas: 182868-72-0) was used in this study.

1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).SDS of cas: 182868-72-0

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Zhang, Dou-Sheng’s team published research in Journal of Planar Chromatography–Modern TLC in 2013 | CAS: 182868-72-0

1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).SDS of cas: 182868-72-0

Zhang, Dou-Sheng; Liu, Wen; Li, Ya-Ping; Hu, Chang-Qin published an article in Journal of Planar Chromatography–Modern TLC. The title of the article was 《Establishment and optimization of an HPTLC method for the analysis of gatifloxacin and related substances by design of experiment》.SDS of cas: 182868-72-0 The author mentioned the following in the article:

The objective of this study was to establish and optimize high-performance thin-layer chromatog. (HPTLC) anal. of gatifloxacin and related substances by the method of design of experiment (DOE). First, preliminary screening of 22 solvents was performed using uniform design (UD) to establish the developing solvent proposed to be optimized. The optimal proportions of components in the developing solvent were established by central composite design (CCD) to establish and validate HPTLC anal. of gatifloxacin and related substances. Using DOE, it was found that the optimal proportions (by volume) of components in the developing solvent in the HPTLC anal. method were methanol-1,2-dichloroethane-concentrated ammonia solution-acetonitrile (2.8:7.2:0.5:0.5, ν/ν). Methodol. validation showed that the established HPTLC method could sep. gatifloxacin and 8 related substances with similar structures effectively. In particular, impurity pairs with the greatest separation difficulty (due to their similar polarities and dipole moments), e.g., impurity #3 (8-fluorogatifloxacin) and impurity #8 (gatifloxacin 2-methylpiperazine), impurity #3, and substance #9 (gatifloxacin), could also be separated effectively. The HPTLC method was simple, accurate, reliable, and suitable for rapid qual. anal. of gatifloxacin and related substances in routine tests. Addnl., the anal. results presented here may provide useful supplemental information on the current reversed phase high-performance liquid chromatog. (RP-HPLC) method, especially in terms of the mechanism of normal-phase separation In the experiment, the researchers used many compounds, for example, 1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0SDS of cas: 182868-72-0)

1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).SDS of cas: 182868-72-0

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics