Category: 182618-86-6piperazines

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.182618-86-6,1-Boc-4-(4-Nitrophenyl)piperazine,as a common compound, the synthetic route is as follows.,182618-86-6

The solvent was removed and the residue was taken up with methanol, Pd-C (10%) was added and stirred under hydrogen overnight at room temperature and then filtered through Celite and concentrated in vacuo. The crude product was purified by flash chromatography to afford 0.457 g product (60%).

As the paragraph descriping shows that 182618-86-6 is playing an increasingly important role.

Reference：
Article; Mou, Jianfeng; Park, Ann; Cai, Yu; Yuan, Junying; Yuan, Chengye; Bioorganic and Medicinal Chemistry Letters; vol. 25; 15; (2015); p. 3057 – 3061;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

182618-86-6, 1-Boc-4-(4-Nitrophenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

10 g (32.6 mmol) of crude I-e was added to a 500 mL one-necked flask,FeO (OH) / C catalyst 1.0 g and 95% ethanol 100 mL,Heating reflux,A 10 mL mixture of hydrazine hydrate and 20 mL of 95% ethanol were slowly added dropwise,TLC detection of raw materials disappeared (methanol:Chloroform = 1:15). Hot filter,The filter cake was washed twice with hot ethanol (30 mL x 2)The solvent was evaporated under reduced pressure to give a white solid,And dried in vacuo to give 7.86 g of (I-f) in a yield of 87.1%.Products without further purification, directly into the next step., 182618-86-6

The synthetic route of 182618-86-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; China Pharmaceutical University; Lu Shuai; Wang Yue; Zhi Yanle; Yao Chao; Lu Tao; Li Baoquan; Chen Puzhou; Bao Jiyin; (27 pag.)CN107245073; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.182618-86-6,1-Boc-4-(4-Nitrophenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: b (8 g, 26.03 mmol) was added in sequence to 50 mL of ethanol.Palladium carbon (1.38g, content 10%), stirring under normal temperature for 5h under hydrogen atmosphere, after the reaction is completed, the palladium carbon is removed by filtration, and the filtrate is evaporated to dryness to obtain c (6.2g);The yield was 85.88%., 182618-86-6

182618-86-6 1-Boc-4-(4-Nitrophenyl)piperazine 3380696, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Zhejiang University; Zhengzhou University; Sun Yi; Liu Hongmin; Xu Tiantian; Li Yanan; Yu Bin; Ma Qisheng; Hou Tingjun; Pan Peichen; Xiong Xiufang; (37 pag.)CN110156729; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.182618-86-6,1-Boc-4-(4-Nitrophenyl)piperazine,as a common compound, the synthetic route is as follows.

A solution of tert-butyl 4-(4-nitrophenyl)piperazine- 1 -carboxylate (8.2 g, 26.68 mmol) inMeOH (100 mL) was purged using nitrogen and reduced pressure. Palladium on charcoal(10% wet) was added and the mixture was hydrogenated (50 psi) for 16 h. The reaction mixture was filtered through diatomaceous earth and concentrated under reduced pressure to give tert-butyl 4-(4-aminophenyl)piperazine-1-carboxylate (7.4 g, 97%) as a dark blue oil used directly into the next step. C15H23N302 MS m/z 277.9 (M+H)., 182618-86-6

As the paragraph descriping shows that 182618-86-6 is playing an increasingly important role.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BIGNAN, Gilles; CONNOLLY, Peter J.; HICKSON, Ian; MEERPOEL, Lieven; PANDE, Vineet; ZHANG, Zhuming; BRANCH, Jonathan; ROCABOY, Christian; TRABALON ESCOLAR, Luis B.; (521 pag.)WO2017/123542; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics