Category: 182181-38-0

182181-38-0, 3-Fluoro-4-(piperazin-1-yl)benzonitrile is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,182181-38-0

tert -Butyl 4-(4-nitrophenyl)piperazine-1-carboxylate (XVII: X=H): To a solution of 1-(nitrophenyl)piperazine (20.7,0.1 mol) and triethylamine (21 ml) in dichloromethane (250 ml) at 0-5 C was added dropwise a solution of di-tert-butyldicarbonate in dichloromethane (50 ml). The resulting mixture was stirred at 0-5 C for 2 h and at room temperature for 18 h. Then the reaction mixture was diluted with 100 ml of chloroform, washed with water, brine and dried over sodium sulphate. The solvent was removed under reduced pressure and the residue was triturated with hexane and hexanelethyl acetate mixture to give the title compound as a yellow solid (29 g, 94%). 1H NMR (CDCl3) delta: 1.5 (s, 9H, 3XCH3), 3.43 (t, 4H, 2XCH2), 3.6 (t, 4H, 2XCH2), 6.8 (d, 2H, Ar-H, J=9 Hz), 8.15 (d, 2H, Ar-H, J=9 Hz).

The synthetic route of 182181-38-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Naeja Pharmaceutical Inc.; TAIHO PHARMACEUTICAL CO., LTD.; EP889881; (2003); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.182181-38-0,3-Fluoro-4-(piperazin-1-yl)benzonitrile,as a common compound, the synthetic route is as follows.

Combine 1-(4-cyano-2-fluorophenyl)piperazine (1.57 g, 7.6 mmol) and Et3N (1.28 ml, 9.2 mmol) in CH2Cl2 (10 ml) and add Boc2O (1.67 g, 7.6 mmol). Stir 1 h wash with satd. NaHCO3. Dry (MgSO4) and concentrate to obtain the crude carbamate as a yellow solid.

182181-38-0, As the paragraph descriping shows that 182181-38-0 is playing an increasingly important role.

Reference£º
Patent; Schering Corporation; US2005/239795; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics