181955-79-3, 1,4-Di-Boc-piperazine-2-carboxylic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
181955-79-3, Step-2 [0552] Method-A [0553] (i) To a dichloromethane (DCM, 40 ml) solution of Boc-protected acid (5.0 g, 15.18 mmol) as prepared in step-1 is added a solution of N-hydroxysuccinimide (1.75 g, 15.21 mmol) in THF (20 ml) and a solution of DCC (3.6 g, 17.47 mmol) in DCM (20 ml) at 0 C. in the order specified. Reaction mixture stirred at 0-5 C. for 4-5 hrs, filtered, filtrate washed successively with water, aqueous sodium bicarbonate solution and finally with brine. Organic layer dried (Na2SO4) evaporated in vacuo to give the product as white solid. (Yield 5.8 g, 86.05%). [0554] (ii) To a solution of the succinimide derivative (1.92 g, 4.49 mmol) in DCM (20 ml) as prepared in (i) of step-2, is added a solution of L-prolinamide (0.6 g, 5.26 mmol). Reaction mixture stirred at 25 C. for 16 hrs. washed with aqueous NaHCO3 solution and brine, dried (Na2SO4), evaporated in vacuo yielding a crude residue. Desired coupled product was isolated by column chromatography (40% ethyl acetate/hexane), (Yield 0.53 g, 27.74%).
The synthetic route of 181955-79-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; TORRENT PHARMACEUTICALS LTD.; US2004/106802; (2004); A1;,
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