Category: 17766-28-8

17766-28-8, 1-Cyclohexylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

About 17.3kg of 4-((3-bromo-6-oxo-6H-anthra[l,9-cd]isoxazol-5- yl)amino)benzoic acid was mixed with about 238L of DMSO. About 11L of TEA and 12kg of 1-cyclohexyl piperazine were added to the reaction. Temperature was then raised to about 60- 65C. After 2-3 hours, slowly added about 116L of MTBE and MeOH (10: 1) solution and adjusted the temperature to 40-50C. The solid was centrifuged and washed by 22.5L of MTBE and MeOH (10: 1) solution and followed by about 22L of MeOH. Solid was dried under reduced pressure at about 25-30C for 12-24 hours. About 1.8kg phosphoric acid was dissolved in 90L of N-methyl pyrrolidone (NMP). Previously obtained crude product was dissolved in about 163L of NMP. Under about 40C, two solutions were mixed together for 1-2 hours. Then about 5.5kg of ECOSORB C-941 in about 20L of NMP was added to the previously mixed solution. The mixture was stirred for another 2- 3 hours under nitrogen protection before filtration. About 600L of purified water was slowly added to the solution under about 40C. Solid was centrifuged and washed with about 21L of water and followed by about 56L of MTBE. Solid was dried under reduced pressure at about 25- 30C for 8-12 hours to obtain the 4-((3 -(4-cyclohexylpiperazin- l-yl)-6-oxo-6H-anthra[ 1,9- cd]isoxazol-5-yl)amino)benzoic acid at about 98% purity and about 91% yield.

17766-28-8, As the paragraph descriping shows that 17766-28-8 is playing an increasingly important role.

Reference：
Patent; PURDUE PHARMA L.P.; WU, Jay Jie-Qiang; WANG, Ling; (31 pag.)WO2017/27465; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17766-28-8,1-Cyclohexylpiperazine,as a common compound, the synthetic route is as follows.

Dissolving Intermediate 5 in DMSO, then adding triethylamine and 1-cyclohexyl piperazine into the solution at temperature about 50-70 C. Adding MTBE and MeOH solution. Isolation and washing of the wet cake with MTBE and MeOH followed by filtering provided Intermediate 6 as a solid

17766-28-8, The synthetic route of 17766-28-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; VM Oncology LLC; Wu, Jay Jie-Qiang; US2015/218132; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

17766-28-8, 1-Cyclohexylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

About 17.3kg of 4-((3-bromo-6-oxo-6H-anthra[l,9-cd]isoxazol-5- yl)amino)benzoic acid was mixed with about 238L of DMSO. About 11L of TEA and 12kg of 1-cyclohexyl piperazine were added to the reaction. Temperature was then raised to about 60- 65C. After 2-3 hours, slowly added about 116L of MTBE and MeOH (10: 1) solution and adjusted the temperature to 40-50C. The solid was centrifuged and washed by 22.5L of MTBE and MeOH (10: 1) solution and followed by about 22L of MeOH. Solid was dried under reduced pressure at about 25-30C for 12-24 hours. About 1.8kg phosphoric acid was dissolved in 90L of N-methyl pyrrolidone (NMP). Previously obtained crude product was dissolved in about 163L of NMP. Under about 40C, two solutions were mixed together for 1-2 hours. Then about 5.5kg of ECOSORB C-941 in about 20L of NMP was added to the previously mixed solution. The mixture was stirred for another 2- 3 hours under nitrogen protection before filtration. About 600L of purified water was slowly added to the solution under about 40C. Solid was centrifuged and washed with about 21L of water and followed by about 56L of MTBE. Solid was dried under reduced pressure at about 25- 30C for 8-12 hours to obtain the 4-((3 -(4-cyclohexylpiperazin- l-yl)-6-oxo-6H-anthra[ 1,9- cd]isoxazol-5-yl)amino)benzoic acid at about 98% purity and about 91% yield.

17766-28-8, As the paragraph descriping shows that 17766-28-8 is playing an increasingly important role.

Reference£º
Patent; PURDUE PHARMA L.P.; WU, Jay Jie-Qiang; WANG, Ling; (31 pag.)WO2017/27465; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics