Category: 163765-44-4piperazines

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.163765-44-4,(R)-1-Boc-3-Methylpiperazine,as a common compound, the synthetic route is as follows.

Example 14; l-Methyl-2-[(2R)-2-methyl-4-(quinoline-2-carbonyl)-piperazin-l-yl]- 1eta- [4,4′]bipyrimidinyl-6-one; (3R)-3’Methvl-4′(l-methvl’6-oxo-l,6-dihvdro-[4,4′]bipvrimidinvl-2’vl)-piperazine-l’car boxvlic acid tert-butvl ester; A solution of 2-chloro-3-methyl-6-(pyrimidin-4-yl)-3H-pyrimidin-4-one (5.3 g, 24 mmol), fer^butyl (Si^-S-methylpiperazine-l-carboxylate (5.0 g, 25 mmol) and triethylamine (7.6 g, 75 mmol) in N-methyl”2-pyrrolidone (25 ml) was stirred for 6 hours at 90 0C. The solution was partitioned between water and ethyl acetate, and the organic layer was washed with water, brine, dried over sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent; ethyl acetate) to afford (3R)-3-methyl-4-(l-methyl-6-oxo-l,6- dihydro-[4,4′]bipyrimidinyl-2-yl)-piperazine”l-carboxylic acid tert-butyl ester (6.9 g, 71 %)..1H NMR; 1.28 (3H, d, J= 7.0 Hz), 1.51 (9H, brs), 3.29-3.52 (4H, m), 3.55 (3H, s), 3.71 (IH, dd, J= 3.9, 13.3 Hz), 3.81-4.02 (2H, m), 7.29 (IH, s), 8.16 (IH, dd, J= 1.6, 5.5 Hz), 8.88 (IH, d, J= 4.7 Hz), 9.25 (IH, s) (CDCl3) MS; [M++ 1] = 387 ., 163765-44-4

As the paragraph descriping shows that 163765-44-4 is playing an increasingly important role.

Reference：
Patent; MITSUBISHI PHARMA CORPORATION; SANOFI-AVENTIS; WO2007/119463; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.163765-44-4,(R)-1-Boc-3-Methylpiperazine,as a common compound, the synthetic route is as follows.

Compound (R) – 3-methyl-piperazine-1-carboxylic acid T-butyl ester (530 mg, 2 . 6mmol), compound quinoline-2-carboxylic acid (450 mg, 2 . 6mmol), 1-ethyl-3 – (3-dimethylamino-propyl) carbodiimide hydrochloride (996 mg, 5 . 2mmol) and N-hydroxy-7-azabenzene and triazazole (530 mg, 3 . 9mmol) dissolved in dichloromethane (10 ml) in, 0 C to this solution under the conditions of adding dropwisely N, N-diisopropyl ethylamine (1.3 ml, 7 . 8mmol), stirring the mixture at room temperature for 10h, and washing with water (10 ml × 3), the organic phase is dried with anhydrous sodium sulfate, removal of solvent, concentrate under column separation (V (petroleum ether)/ V (ethyl acetate) =1/1) get 820 mg white solid, yield: 88%., 163765-44-4

163765-44-4 (R)-1-Boc-3-Methylpiperazine 2756811, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd.; Yu, Tianzhu; Liu, Bing; Zhang, Yingjun; Zhang, Xiangyu; Zhang, Zhiguo; Zheng, Changchun; Zhang, Jiancun; Lei, Jianhua; (66 pag.)CN105461693; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.163765-44-4,(R)-1-Boc-3-Methylpiperazine,as a common compound, the synthetic route is as follows.,163765-44-4

Example 129: Synthesis of N -(( E )-5-hydroxyadamantan-2-yl)-6-(( R )-2-methylpiperazin-1-yl)picolinamide (Intermediate 10) [325] [326] Step 1: Synthesis of ( R )-tert-butyl 4-(6-((( E )-5-hydroxyadamantan-2-yl)carbamoyl)pyridin-2-yl)-3-methylpiperazine-1-carboxylate [327] 6-Bromo-N-((E)-5-hydroxyadamantan-2-yl)picolinamide(1.0 g, 2.847 mmol), (R)-tert-butyl 3-methylpiperazine-1-carboxylate (855 mg, 4.271 mmol), Pd2(dba)3 (52 mg, 0.057 mmol), xantphos (99 mg, 0.171 mmol), and sodium-tert-butoxide (410 mg, 4.271 mmol) were suspended in toluene (20 ml), and then the resulting liquid was stirred at 100oC under nitrogen stream for 3 hours. A saturated aqueous ammonium chloride solution (20 ml) was added to the resulting reaction liquid, followed by extraction with MC (40 ml x 2). The organic layer was dried over anhydrous sodium sulfate, followed by filtration and concentration, and then the residue thus obtained was subjected to MPLC (90% EtOAc/Hexanes), to obtain 720 mg of pale yellow solid (54%).

163765-44-4 (R)-1-Boc-3-Methylpiperazine 2756811, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; SK Chemicals Co.,Ltd.; RYU, Je Ho; KIM, Shin Ae; RYU, Keun Ho; KIM, Jae Sun; KIM, Nam Ho; HAN, Hye Young; KIM, Yong Hyuk; YOUN, Won-No; LEE, Yoon-Jung; SON, Hyun Joo; LEE, Bong-yong; PARK, Sung Hoon; LEE, Ju Young; LEE, Hyun Jung; JUNG, Hoe Chul; SHIN, Young Ah; LEE, Jung A; LEE, Bo Ram; SA, Joon Ho; WO2011/139107; (2011); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

163765-44-4, (R)-1-Boc-3-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of (R) -tert-butyl3-methylpiperazine-1-carboxylate (500 mg, 2.5 mmol) and triethylamine (700 mg,6.3 mmol) in DCM (10 mL) was added methylsulfamoyl chloride (0.39 mL,4.99 mmol) at 0 dropwise. The mixture was stirred at rt for 8 h, and washedwith water (10 mL ¡Á 3) . The combined organic layer were dried over anhydrousNa2SO4 and concentrated. The residue was purified bysilica gel chromatography eluted with Petroleum ether/EtOAc (v/v) 2/1 to give(R) -tert-butyl 3-methyl-4- (methylsulfonyl) piperazine-1-carboxylate as awhite solid (444 mg, 63) . 1H NMR (400 MHz, CDCl3): delta ppm 4.04-4.24 (m, 2H) , 3.82-3.98 (m, 1H) , 3.54 (d, J 12.7 Hz, 1H) ,3.14-3.21 (m, 1H) , 3.04-3.18 (m, 1H) , 2.87-3.00 (m, 1H) , 2.88 (s, 3H) , 1.48(s, 9H) , 1.26 (d, J 6.8 Hz, 3H) and MS-ESI: m/z 223.15 [M-55] +., 163765-44-4

The synthetic route of 163765-44-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; LIU, Bing; YU, Tianzhu; ZHANG, Xiangyu; ZHANG, Shiguo; ZHANG, Jiancun; CHENG, Changchung; (426 pag.)WO2016/34134; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

163765-44-4, (R)-1-Boc-3-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 27(3R)-tert-butyl 3-methyl-4-(7-(methylsulfonyl)-7-azaspiro[3.5]nonane-2-carbonyl)piperazine-1-carboxylate Oxalyl chloride (0.127 mL, 1.46 mmol) was slowly added to a solution of Intermediate 26 (120 mg, 0.49 mmol) in DCM (12 mL) at 0 C. One drop of DMF was added and the reaction mixture was stirred for 4 h. The solvent was concentrated. The residue was quickly recovered in DCM (5 mL) and added to a solution of (R)-tert-butyl 3-methylpiperazine-1-carboxylate (97 mg, 0.49 mmol) and Et3N (0.338 mL, 2.43 mmol) in DCM (12 mL) at 0 C. The reaction mixture was allowed to warm to ambient temperature and stirred for 1 h. The solvent was concentrated and the product was purified on silica gel (24 g) by MPLC using 5% MeOH and 10% acetone in DCM as the eluent to provide title compound (111 mg, 53.3%) as a solid. 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 1.14 (d, J=7.03 Hz, 2H) 1.22 (d, J=6.64 Hz, 2H) 1.47 (s, 9H) 1.63-1.72 (m, 2H) 1.72-1.84 (m, 2H) 1.92-2.30 (m, 4H) 2.76 (s, 3H) 2.78-3.03 (m, 2H) 3.11 (t, J=5.66 Hz, 2H) 3.14-3.29 (m, 4H) 3.30-3.42 (m, 1H) 3.84 (br. s., 1H) 4.30-4.82 (m, 1H); MS m/z 430.3 [M+H]+ (ES+)., 163765-44-4

As the paragraph descriping shows that 163765-44-4 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; US2010/130477; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics