Category: 16153-81-4

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 16153-81-4, Name is 4-(4-Methylpiperazin-1-yl)phenylamine, SMILES is NC1=CC=C(N2CCN(C)CC2)C=C1, belongs to piperazines compound. In a document, author is Oa, Seyeon, introduce the new discover, Quality Control of 4-(4-Methylpiperazin-1-yl)phenylamine.

Effects of carbonation on carbon dioxide capture and the mechanical properties of concrete with amine sorbents

Carbon dioxide (CO2) uptake and the mechanical strength of concrete with and without carbon-dioxide-philic (CDP) amine sorbents were assessed in this study. Cement pastes with three amine-based sorbents (5-amino-1 pentanol, piperazine and 3-amino-1-propanesulfonic acid) were hydrated for 28 d. They were then assessed for carbon dioxide uptake and compressive/bending strength. The carbon dioxide in the atmosphere was sequestrated into the concrete as simulated carbonation weathering occurred, and the carbon dioxide uptake was measured using thermogravimetric analysis. Carbon dioxide uptake increased when CDP amine sorbents were mixed into the concrete specimens, with 5-amino-1-pentanol and piperazine showing the best efficiency, with carbon dioxide uptakes of 2.44% and 2.24%, respectively. The compressive and bending strengths also increased with carbonation. The strengths of the concretes with CDP sorbents were higher than that of ordinary concrete due to the microstructurel densification, indicating that urban carbon dioxide sequestration can be performed using concrete structures without damaging their structural strength.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 16153-81-4 is helpful to your research. Quality Control of 4-(4-Methylpiperazin-1-yl)phenylamine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Computed Properties of C11H17N3, 16153-81-4, Name is 4-(4-Methylpiperazin-1-yl)phenylamine, molecular formula is C11H17N3, belongs to piperazines compound. In a document, author is Okhlopkova, L. S., introduce the new discover.

Mononuclear Antimony(V) Catecholate Complexes with Additional Pyridine Ligands

A series of triarylantimony(V) complexes withp-dimethylaminopyridine andp-cyanopyridine of the general formulas [(Cat)SbAr3(p-Me2N-Py)] (complexesI-IV) and [(Cat)SbAr3(p-CN-Py)] (complexesV-VII) has been synthesized. Their molecular structures and electrochemical properties have been studied. 3,6-Di-tert-butyl-o-benzoquinone, 4,5-piperazine-1,4-diyl-3,6-di-tert-butyl-o-benzoquinone, and 4,5-dichloro-3,6-di-tert-butyl-o-benzoquinone are used as redox-active ligands. The molecular structures of several complexes in the crystalline state are determined by X-ray diffraction analysis (CIF files CCDC nos. 1974173 (I. 0.5toluene), 1974174 (II. 2toluene), 1974175 (V), 1974176 (VI. hexane), and 1974177 (VII)). All complexes have a distorted octahedral structure, and an additional neutral pyridine ligand occupies one of the apical positions. Electrochemical transformations of the complexes are studied by cyclic voltammetry in a dichloromethane solution. The introduction of substituted pyridine into the molecule of the complex does not change the electrooxidation mechanism of the complexes. For all complexes withp-dimethylaminopyridine, both oxidation potentials are shifted to the cathodic region (0.13-0.21 V for the potential of the first oxidation process and to 0.3-0.4 V for the potential of the second oxidation process). A similar shift for the complex withp-cyanopyridine is less pronounced (0.05 V for the potential of the first oxidation process of complexVas compared to that of complexI).

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 16153-81-4. Computed Properties of C11H17N3.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Application of 16153-81-4, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 16153-81-4, Name is 4-(4-Methylpiperazin-1-yl)phenylamine, SMILES is NC1=CC=C(N2CCN(C)CC2)C=C1, belongs to piperazines compound. In a article, author is Kamaal, Saima, introduce new discover of the category.

Fabrication of a new 2D Co(II)-organic framework tuned by semi-flexible dicarboxylate and 1,4-bis(4-pyridinylmethyl)piperazine ligands: Topology, DFT/UB3LYP calculations, Hirshfeld surface analysis and magnetic studies

A new 2D-coordination polymer, {[Co-3(L-2)(2)(HL-)(2)(bPmP)](H2O)(2)}n (CP1) was synthesized by using a dicarboxylate ligand, H2L (5-benzylamino-isophthalic acid) and a nitrogen donor ligand 1,4-bis(4-pyridinylmethyl)piperazine (bpmp) with Co(NO3)(2)center dot 6H(2)O under hydrothermal conditions via careful tuning the basicity of reaction conditions. Single crystal X-ray studies revealed that CP1 exist as a linear trinuclear cobalt cluster. DFT/UB3LYP/6-31G(d,p) calculations have been performed to study the ground state molecular geometry, IR spectrum, magnetic behavior by electron spin densities distribution as well as to explore various structure based molecular properties. The topological analysis of CP1 results an underlying sql net with a point symbol of {4(4).6(2)}.Variable temperature magnetic susceptibility measurements of CP1 were carried out over the temperature range 2-300 K which indicates the existence of paramagnetic behavior. (C) 2020 Elsevier B.V. All rights reserved.

Application of 16153-81-4, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 16153-81-4.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Synthetic Route of 16153-81-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 16153-81-4, Name is 4-(4-Methylpiperazin-1-yl)phenylamine, SMILES is NC1=CC=C(N2CCN(C)CC2)C=C1, belongs to piperazines compound. In a article, author is Muresan-Pop, M., introduce new discover of the category.

Structural characterization of 5-fluorouracil & piperazine new solid forms and evaluation of their antitumor activity

A salt (FP-S) and two co-crystals (FP-C1 and FP-C2) of fluorouracil (FU) with piperazine (PZ) were investigated in terms of bioavailability and their effect on endothelial cells. From structural point of view, the best stability was observed for FP-C2 sample obtained by storage of FP-C1 sample under extreme conditions of temperature and humidity. This result was explained by the strong intermolecular interactions between 5-fluorouracil, piperazine and water, as denoted by the crystallographic analysis of FP-C2 form. Dissolution measurements in water indicate that the most soluble form is the salt, with a dissolution rate about 3 times greater than for the fluorouracil pure compound, while the solubility for co-crystals decreases compared to FU. Toxicity and antitumoral effect of the synthesized compounds were checked on three different cell lines: normal cells (HUVEC endothelial cells) and tumor cells (DLD-1 and HT29, both colorectal adenocarcinoma) and cytotoxicity by the MTT assay and cell proliferation assay. It has been found that the FP-C1 exerts a selective cytotoxic effect on HT29 cells and FP-C2 on DLD-1 cells in contrast to normal endothelial cell line resistance. For FU and FP-S salt, the effect on normal and tumoral cells is similar. The comparative study of the three fluorouracil forms shows that the best antitumor selective response was obtained for the co-crystal forms. (C) 2020 Elsevier B.V. All rights reserved.

Synthetic Route of 16153-81-4, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 16153-81-4 is helpful to your research.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , SDS of cas: 16153-81-4, 16153-81-4, Name is 4-(4-Methylpiperazin-1-yl)phenylamine, molecular formula is C11H17N3, belongs to piperazines compound. In a document, author is Zahradnikova, Eva, introduce the new discover.

Late first-row transition metal complexes of a 17-membered piperazine-based macrocyclic ligand: structures and magnetism

A 17-membered piperazine-based macrocyclic ligandL(diProp)(1,5,13,17,22-pentaazatricyclo[15.2.2.17,11]docosa-7,9,11(22)-triene) was resynthesized in high yield by using a linear pump. Its Mn(ii), Fe(ii), Co(ii) and Ni(ii) complexes of the general formula [MnLdiProp(ClO4)(2)] (1), [FeLdiProp(CH3CN)](ClO4)(2)(2), [CoLdiProp(CH3CN)](ClO4)(2)(3), [NiLdiProp](ClO4)(2)(4) were prepared and thoroughly characterized. X-ray diffraction analysis confirmed that Mn(ii) complex1has capped trigonal prismatic geometry with a coordination number of seven, Fe(ii) and Co(ii) complexes2and3are trigonal prismatic with a coordination number of six and Ni(ii) complex4has square pyramidal geometry with a coordination number of five. The decrease of the coordination number is accompanied by a shortening of M-N distances and an increase of torsion of the piperazine ring from the equatorial plane. Magnetic measurement reveals moderate anisotropy for4and rather large magnetic anisotropy for2and3(axial zero-field splitting parameterD(Ni) = 9.0 cm(-1),D(Fe) = -14.4 cm(-1),D(Co) = -25.8 cm(-1), together with rather high rhombicity). Co(ii) complex3behaves as a field-induced SMM with a combination of Raman and direct or Orbach and direct relaxation mechanisms. Obtained magnetic data were extensively supported by theoretical CASSCF calculations. The flexibility and rather large 17-membered macrocyclic cavity of ligandL(diProp)could be responsible for the variation of coordination numbers and geometries for the investigated late-first row transition metals.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 16153-81-4. SDS of cas: 16153-81-4.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Application In Synthesis of 4-(4-Methylpiperazin-1-yl)phenylamine, 16153-81-4, Name is 4-(4-Methylpiperazin-1-yl)phenylamine, SMILES is NC1=CC=C(N2CCN(C)CC2)C=C1, belongs to piperazines compound. In a document, author is Listro, Roberta, introduce the new discover.

Exploring the RC-106 Chemical Space: Design and Synthesis of Novel (E)-1-(3-Arylbut-2-en-1-yl)-4-(Substituted) Piperazine Derivatives as Potential Anticancer Agents

Despite the fact that significant advances in treatment of common cancers have been achieved over the years, orphan tumors still represent an important unmet medical need. Due to their complex multifactorial origin and limited number of cases, such pathologies often have very limited treatment options and poor prognosis. In the search for new anticancer agents, our group recently identifiedRC-106, a Sigma receptor modulator endowed with proteasome inhibition activity. This compound showed antiproliferative activity toward different cancer cell lines, among them glioblastoma (GB) and multiple myeloma (MM), two currently unmet medical conditions. In this work, we directed our efforts toward the exploration of chemical space aroundRC-106to identify new active compounds potentially useful in cancer treatment. Thanks to a combinatorial approach, we prepared 41 derivatives of the compound and evaluated their cytotoxic potential against MM and GB. Three novel potential anticancer agents have been identified.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 16153-81-4. Application In Synthesis of 4-(4-Methylpiperazin-1-yl)phenylamine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Category: piperazines, 16153-81-4, Name is 4-(4-Methylpiperazin-1-yl)phenylamine, SMILES is NC1=CC=C(N2CCN(C)CC2)C=C1, belongs to piperazines compound. In a document, author is Behroozi, Amir Hossein, introduce the new discover.

CO2 Reactive Absorption into an Aqueous Blended MDEA and TMS Solution: Experimental and Modeling

In this research, the significant environmental process of CO2 capture is investigated into an aqueous blended MDEA + TMS solution using a stirrer reactor experimentally and numerically. The experiments were designed based on the response surface methodology (RSM) under operating conditions of a pressure range of 2-8 bar, a temperature range of 20-70 degrees C, MDEA, and TMS concentration range of 10-20 wt%. The results indicated that by enhancing the initial pressure from 3.5 to 8 bar, the equilibrium CO2 loading increases by 17.8%. Based on RSM and central composite design method, the maximum values of CO2 loading and absorption percentages were 0.308% and 72.73%, respectively, at appropriate conditions of the temperature of 32.5 degrees C, the pressure of 3.5 bar, and MDEA and TMS concentrations of 12.5 wt%. A new relation for CO2 loading was correlated with a correlation coefficient of 0.994, as a function of studied independent variables.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 16153-81-4 is helpful to your research. Category: piperazines.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Quality Control of 4-(4-Methylpiperazin-1-yl)phenylamine, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 16153-81-4, Name is 4-(4-Methylpiperazin-1-yl)phenylamine, molecular formula is C11H17N3. In an article, author is Qiu, Xiang,once mentioned of 16153-81-4.

Design, synthesis and anti-inflammatory study of novel N-heterocyclic substituted Aloe-emodin derivatives

A novel series of Aloe-emodin derivatives containing N-heterocyclic moieties was designed and synthesized. The structure-activity relationship studies (SARs) indicated that the replacement of hydroxyethyl and benzhydryl piperazine groups could improve efficacy. Compounds12rand14a-14cexhibited a higher inhibitory effect on LPS-induced nitric oxide (NO) production in RAW264.7 macrophages than Aloe-emodin did. Among them,12rshowed the most potent inhibition with an IC(50)value of 5.66 +/- 0.47 mu M. Further toxicity and pharmacokinetic studies were carried out and12rwas found to be the most active structure with low toxicity risk and good metabolic properties. It could also decrease the levels of IL-1 beta, TNF-alpha, PGE(2)and inhibit the activation of nuclear factor-kappa B signalling pathway. Importantly,12rshowed oral bioavailability of up to 55.16% and attenuated the inflammatory symptoms in an ulcerative colitis mouse model in vivo. These results indicate that12ris suitable for development as an anti-inflammatory agent.

If you¡¯re interested in learning more about 16153-81-4. The above is the message from the blog manager. Quality Control of 4-(4-Methylpiperazin-1-yl)phenylamine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Electric Literature of 16153-81-4, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 16153-81-4, Name is 4-(4-Methylpiperazin-1-yl)phenylamine, SMILES is NC1=CC=C(N2CCN(C)CC2)C=C1, belongs to piperazines compound. In a article, author is Rai, Sunil K., introduce new discover of the category.

Salts and Cocrystal of Etodolac: Advantage of Solubility, Dissolution, and Permeability

Etodolac (ETD) is a nonsteroidal anti-inflammatory drug (NSAID) approved by the United States Food and Drug Administration (US-FDA) in 1991 for the treatment of rheumatoid arthritis. Because of its poor aqueous solubility and high permeability, ETD falls under Biopharmaceutics Classification System (BCS) Class II drug. The present study was aimed to screen stable salts and cocrystals of ETD using Generally Recognized as Safe (GRAS) and a few non-GRAS coformers. Crystallization of five salts (i.e., isopropylamine = isoPA, n-hexylamine = nHA, cyclohexylamine = cycloHA, 2-phenylethylamine = phEA, piperazine = PPZ) and one cocrystal (isonicotinamide = INT) was successful. These products were characterized by single crystal X-ray and powder diffraction. Differential scanning calorimetry (DSC) showed a single endotherm for the salts, which confirmed their thermal stability and phase homogeneity, except for ETD(-center dot)phEA(+) where a solid-solid transition at 152 degrees C was observed with an enthalpy of transition Delta H approximate to 16 J/g. Among the five salts, ETD(-center dot)isoPA(+) showed the highest solubility of 267.50 mg/mL and similar to 20 times faster intrinsic dissolution rate than ETD in pH 7.0 phosphate buffer medium. The salts are stable under solubility and dissolution conditions as confirmed by fitting the powder X-ray diffraction profile of each sample after the experiment with the calculated lines from the X-ray structure. Permeability and flux analysis of ETD salts showed that ETD(-center dot)isoPA(+) exhibits a high flux rate across the semipermeable membrane due to a higher molecular mobility and greater concentration gradient.

Electric Literature of 16153-81-4, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 16153-81-4 is helpful to your research.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 16153-81-4, Name is 4-(4-Methylpiperazin-1-yl)phenylamine, molecular formula is C11H17N3. In an article, author is Sharif, Maimoona,once mentioned of 16153-81-4, Category: piperazines.

Evaluation of CO2 absorption performance by molecular dynamic simulation for mixed secondary and tertiary amines

CO2 emission to the atmosphere is the most prominent cause of climate change and a major risk to environmental health. Although several techniques are very promising to reduce the CO2 emission from central emission points, the CO2 absorption by amines remains the most mature and reliable technology. Yet, there is more potential to improve absorption performance by choosing suitable solvents. Thus, the present research is intended to explore a better solvent combination for CO2 absorption by adopting the amine absorption process using molecular dynamic simulation. The study is designed to compare the intermolecular interactions of N-C and N-H bond between single 2EAE, DMAE (or 2DMAE), and blended solvent, i.e., 2EAE/PZ, 2DMAE/PZ with carbon dioxide and water and then to catch the effect of piperazine on these amines. The molecular dynamic simulations were performed by using the Material Studio application. The solvent concentration, 30 wt% under the condition of 313 K temperature at 0.1 MPa pressure, was taken for solvent systems. The results were interpreted by the Radial Distribution Function analysis. It was found that the blend of secondary and tertiary amines with piperazine 2EAE/PZ, DMAE/PZ reflect higher intermolecular interaction with CO2 as compared to single DMAE & 2EAE. This finding shows that piperazine acts as a promoter on 2EAE and 2DMAE when interacting with CO2.

Interested yet? Keep reading other articles of 16153-81-4, you can contact me at any time and look forward to more communication. Category: piperazines.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics